SavedAdd your journal

Journals / Turkish Journal of Cancer / 2000 / Cilt: 30 - Sayı: 2

Nasopharyngeal carcinoma case with glutathione-S-transferase-$pi$ positivity by immunohistochemistry

Hasan ÜSTÜN
Burhan SAVAŞ
Gülten KARPUZOĞLU
Melek ÜSTÜN
Pages
86–88
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Detection of glutathione S-transferase-$pi$ positivity by immunohistochemistry may affect therapy modalities in chemotherapy resistant cases

📌 3 Key Takeaways

🎯
Objective & Hypothesis:This report describes a case of stage IV undifferentiated nasopharyngeal carcinoma with glutathione S-transferase-$pi$ positivity shown in the lymph node metastasis by immunohistochemistry.
📊
Key Findings & Data:Chemotherapy resistance is a major problem in the treatment of patients with nasopharyngeal carcinoma and glutathione S-transferases contribute to the resistance.
💡
Conclusion & Impact:Detection of glutathione S-transferase-$pi$ positivity by immunohistochemistry may affect therapy modalities in chemotherapy resistant cases
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This report describes a case of stage IV undifferentiated nasopharyngeal carcinoma with glutathione S-transferase-$pi$ positivity shown in the lymph node metastasis by immunohistochemistry. Chemotherapy resistance is a major problem in the treatment of patients with nasopharyngeal carcinoma and glutathione S-transferases contribute to the resistance. Detection of glutathione S-transferase-$pi$ positivity by immunohistochemistry may affect therapy modalities in chemotherapy resistant cases

🔖

Cite This Article

ÜSTÜN, H., SAVAŞ, B., KARPUZOĞLU, G., ÜSTÜN, M. (2022). Nasopharyngeal carcinoma case with glutathione-S-transferase-$pi$ positivity by immunohistochemistry. Turkish Journal of Cancer, Cilt: 30 - Sayı: 2, 86–88. https://ajindex.com/articles/601309

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Fandi A, Altun M, Azli N, et al. Nasopharyngeal cancer: epidemiology, staging and treatment. Semin Oncol 1994;21:382-97
  2. Salinas AE, Wong MG. Glutathione S-transferases: a review. Curr Med Chem 1999;6:279-309
  3. O’Brien ML, Tew KD. Glutathione and related enzymes in multidrug resistance. Eur J Cancer 1996;32:967-8
  4. Tanita J, Tsuchida S, Hozawa J, et al. Expression of glutathione Stransferase- pi in human squamous cell carcinomas of the pharynx and larynx. Loss after radiation therapy. Cancer 1993;72:569-76
  5. Boussen H, Cvitkovic E, Wendling JL, et al. Chemotherapy of metastatic and/or recurrent undifferentiated nasopharyngeal carcinoma with cisplatin, bleomycin and fluorouracil. J Clin Oncol 1991;9:1675-81
  6. Nishimura T, Newkirk K, Sessions RB, et al. Immunohistochemical staining for glutathione S-transferase predicts response to platinum-based chemotherapy in head and neck cancer. Clin Cancer Res 1996;2:1859-65
  7. Bailey HH, Mulcahy RT, Tutsch KD, et al. Phase I clinical trial of intravenous L-Buthionine sulphoximine and melphalan: an attempt at modulation of glutathione. J Clin Oncol 1994;12:194-205
  8. Awasthi S, Sharma R, Singhal SS, et al. Modulation of cisplatin cytotoxicity by sulphasalazine. Br J Cancer 1994;70:190-4
  9. O’Dwyer PJ, LaCreta F, Nash S, et al. Phase I study of thiotepa in combination with the glutathione transferase inhibitor etachrynic acid. Cancer Res 1991;51:6059-65.