Host variations in SARS-CoV-2 infection

Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.

📌 3 Key Takeaways

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Objective & Hypothesis:t: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the “Coronavirus Disease of 2019 (COVID-19)”, and COVID-19 itself is yet to be thoroughly understood.

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Key Findings & Data:Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened.

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Conclusion & Impact:Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.

🔬Design:Research Article

📍Scope:2019 Verileri

⚙️Variables:Domain Parameters

Abstract

t: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the “Coronavirus Disease of 2019 (COVID-19)”, and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors –e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.

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Cite This Article

KILIÇ, P., DORA, D. D., ALTUNTAŞ, E. G., KARAGÜLLEOĞLU, Z. Y., SEVAL, G. C., MENDİ, H. A., ALTIOK, D., SAVCI, E. Z., ÖZKARA, B., TUNÇER, G., KILINÇ, B. R., SUİÇMEZ, E., ÇETİN, G., UNCUOĞLU, D. B., TEKELİ, C., BENGİ, V. U., Si, S. (2022). Host variations in SARS-CoV-2 infection. Turkish Journal of Biology, Cilt: 45 - Sayı: 4, 404–424. https://ajindex.com/articles/600114

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References (3)

Abadom TR, Smith AD, Tempia S, Madhi SA, Cohen C et al. (2016). Risk factors associated with hospitalisation for influenzaassociated severe acute respiratory illness in South Africa: A case-population study. Vaccine 34 (46): 5649-5655. doi: 10.1016/j.vaccine.2016.09.011 Abedi V, Olulana O, Avula V, Chaudhary D, Khan A et al. (2020). Racial, economic, and health inequality and COVID-19 infection in the United States. Journal of Racial and Ethnic Health Disparities 1. Preprint MedRxiv. doi: 10.1007/s40615- 020-00833-4
Acharya D, Lee K, Lee DS, Lee YS, Moon S-S (2020). Mortality rate and predictors of mortality in hospitalized COVID-19 patients with diabetes. Healthcare (Basel, Switzerland), 8 (3): 1-8. doi: 10.3390/healthcare8030338 Ali F, Kasry A, Amin M (2021) The new SARS-CoV-2 strain shows a stronger binding affinity to ACE2 due to N501Y mutant. Medicine in Drug Discovery 10: 100086. doi: 10.1016/j. medidd.2021.100086 Almerich-Silla JM, Almiñana-Pastor PJ, Boronat-Catalá M, BellotArcís C, Montiel-Company JM (2017). Socioeconomic factors and severity of periodontal disease in adults (35-44 years). A cross sectional study. Journal of Clinical and Experimental Dentistry 9 (8): e988–e994. doi: 10.4317/jced.54033 Amodio F, Caiazza M, Calabrò P, Limongelli G (2021). Genetic susceptibility to SARS-CoV-2: from the Nehandertal age to 2020. Cardiogenetics 11 (1): 28-30. doi: 10.3390/ cardiogenetics11010004 Antalis TM, Bugge TH, Wu Q (2011). Membrane-anchored serine proteases in health and disease. In Progress in Molecular Biology and Translational Science 99 (C), pp. 1–50. Elsevier B.V. doi: 10.1016/B978-0-12-385504-6.00001-4
Antony P, Vijayan R (2021). Role of SARS-CoV-2 and ACE2 variations in COVID-19, Biomedical Journal ISSN 2319-4170. doi: 10.1016/j.bj.2021.04.006 Asselta R, Paraboschi EM, Mantovani A, Duga S (2020). ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy. Aging 12 (11) 10087–10098. doi: 10.18632/aging.103415 Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ et al. (2013). ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes and Development, 27 (6): 683–698. doi: 10.1101/gad.211011.112 Bansal M. (2020). Cardiovascular disease and COVID-19. Diabetes & metabolic syndrome 14 (3): 247–250. doi: 10.1016/j. dsx.2020.03.013 Batool Z, Haroon Durrani S, Tariq S (2017). Association of Abo and Rh Blood Group Types to Hepatitis B, Hepatitis C, H