Journals / Trends in pediatrics / 2021 / Cilt: 2 - Sayı: 4

The Effects of Growth Hormone Treatment in Patients with Isolated Growth Hormone Deficiency on Hematological Parameters

Pages
165–169
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The statistical analyses were made using SPSS v.20 Package Program, and the significance level was accepted as p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: A small number of studies were reported regarding the direct and indirect effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) especially on the erythrocyte series.
📊
Key Findings & Data:Methods: The records of the patients who were diagnosed as having IGHD in our clinic and received GHT for at least two years between 2013 and 2019 were retrospectively examined.
💡
Conclusion & Impact:The statistical analyses were made using SPSS v.20 Package Program, and the significance level was accepted as p
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: A small number of studies were reported regarding the direct and indirect effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) especially on the erythrocyte series. The purpose of this study was to examine the effects of GH treatment (GHT) used in patients with isolated GH deficiency (IGHD) on hematological parameters. Methods: The records of the patients who were diagnosed as having IGHD in our clinic and received GHT for at least two years between 2013 and 2019 were retrospectively examined. Height, height standard deviation scores (SDS), weight, weight SDS, IGF-1, annual growth rates, and changes in blood count parameters before and after the GHT were recorded. The statistical analyses were made using SPSS v.20 Package Program, and the significance level was accepted as p

🔖

Cite This Article

ÇAYIR, A., ŞENGÜN, D. (2022). The Effects of Growth Hormone Treatment in Patients with Isolated Growth Hormone Deficiency on Hematological Parameters. Trends in pediatrics, Cilt: 2 - Sayı: 4, 165–169. https://ajindex.com/articles/598895

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah growth study: growth standards and the prevalence of growth hormone deficiency. J Pediatr. 1994;125:29-35
  2. Stanley T. Diagnosis of growth hormone deficiency in childhood. Curr Opin Endocrinol Diabetes Obes. 2012;19:47-52
  3. Bianchi A, Giampietro A, Pontecorvi A, De Marinis L. Isolated growth hormone deficiency: clinical entity? J Endocrinol Invest. 2008;31(9 Suppl 9):12-5
  4. Jørgensen AP, Fougnnger KJ, Ueland T, et al. Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency. Growth Horm IGF Res. 2011;21:69-75
  5. Follin C, Thilén U, Osterberg K, Björk JK, Erfurth EM. Cardiovascular risk, cardiac function, physical activity, and quality of life with and without long-term growth hormone therapy in adult survivors of childhood acute lymphoblastic leukemia. J Clin Endocrinol Metab. 2010;95:3726-35
  6. Kurtz A, Zapf J, Eckardt KU, et al. Insulin-like growth factor I stimulates erythropoiesis in hypophysectomized rats. Proc Natl Acad Sci U S A. 1988;85:7825-9. 7. von Elm E, Altman DG Egger M, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guildelines for reporting observational studies. J Clin Epidemiol. 2008;61:344-9
  7. Hernández LM, Lee PDK, Camacho-Hübner C. Isolated growth hormone deficiency. Pituitary. 2007;10:351-7
  8. Neyzi O, Bundak R, Gökçay G, et al. Reference values for weight, height, head circumference, and body mass index in Turkish Cchildren. J Clin Res Pediatr Endocrinol. 2015;7:280-93
  9. Ranke MB. Pediatric growth hormone deficiency (GHD) in the recombinant human GH (rhGH) Eera. Pediatr Endocrinol Rev. 2018;16 (Suppl 1):63-9
  10. Lenth R. Java Applets for Power and Sample Size [Computer software]. Russ Lenth - Department of Statistics and Actuarial Science - University of Iowa, 2009
  11. Eugster EA, Fisch M, Walvoord EC, DiMeglio LA, Pescovitz OH. Low hemoglobin levels in children with in idiopathic growth hormone deficiency. Endocrine. 2002;18:135-6
  12. Vihervuori E, Sipilä I, Siimes MA. Increases in hemoglobin concentration and iron needs in response to growth hormone treatment. J Pediatr. 1994;125:242-5
  13. Kawa MP, Stecewicz I, Piecyk K, et al. The impact of growth hormone therapy on the apoptosis assessment in CD34+ hematopoietic cells from children with growth hormone deficiency.