Objective & Hypothesis:To evaluate the vitamin B12 (VB12) deficiency in patients with type 2 diabetes mellitus (DM-2) using metformin or other hypoglycemic agents.
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Key Findings & Data:Methods. 400 patients with DM-2 were divided into two arms (N = 200/group); 1) those receiving metformin (MET) for at least six months and 2) those receiving hypoglycemic agents other than metformin (OHA).
Objectives. To evaluate the vitamin B12 (VB12) deficiency in patients with type 2 diabetes mellitus (DM-2) using metformin or other hypoglycemic agents. Methods. 400 patients with DM-2 were divided into two arms (N = 200/group); 1) those receiving metformin (MET) for at least six months and 2) those receiving hypoglycemic agents other than metformin (OHA). Serum VB12 concentrations were measured. Data were analyzed by using two-sample t-test for numerical data and chi-square with logistic regression analysis for categorical data. Numerical values were expressed as means ± standard deviations. Null hypotheses were rejected at P < 0.05. Results. Definite biochemical VB12 deficiency (
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Cite This Article
NİAFAR, M., JAMALİ, B., BAKHSHAİESH, N. L., AGHAMOHADZADEH, N., NADER, N. D. (2022). The Role of Metformin on Serum Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus. The European Research Journal, Cilt: 1 - Sayı: 1, 1–7. https://ajindex.com/articles/597827
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