Journals / The European Research Journal / 2015 / Cilt: 1 - Sayı: 1

The Role of Metformin on Serum Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus

Pages
1–7
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Definite biochemical VB12 deficiency (

📌 3 Key Takeaways

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Objective & Hypothesis:To evaluate the vitamin B12 (VB12) deficiency in patients with type 2 diabetes mellitus (DM-2) using metformin or other hypoglycemic agents.
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Key Findings & Data:Methods. 400 patients with DM-2 were divided into two arms (N = 200/group); 1) those receiving metformin (MET) for at least six months and 2) those receiving hypoglycemic agents other than metformin (OHA).
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Conclusion & Impact:Definite biochemical VB12 deficiency (
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives. To evaluate the vitamin B12 (VB12) deficiency in patients with type 2 diabetes mellitus (DM-2) using metformin or other hypoglycemic agents. Methods. 400 patients with DM-2 were divided into two arms (N = 200/group); 1) those receiving metformin (MET) for at least six months and 2) those receiving hypoglycemic agents other than metformin (OHA). Serum VB12 concentrations were measured. Data were analyzed by using two-sample t-test for numerical data and chi-square with logistic regression analysis for categorical data. Numerical values were expressed as means ± standard deviations. Null hypotheses were rejected at P < 0.05. Results. Definite biochemical VB12 deficiency (

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Cite This Article

NİAFAR, M., JAMALİ, B., BAKHSHAİESH, N. L., AGHAMOHADZADEH, N., NADER, N. D. (2022). The Role of Metformin on Serum Vitamin B12 Levels in Patients with Type 2 Diabetes Mellitus. The European Research Journal, Cilt: 1 - Sayı: 1, 1–7. https://ajindex.com/articles/597827

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References (13)

  1. American Diabetes A. Standards of medical care in diabetes-- 2014. Diabetes Care. 2014;37 Suppl 1:S14-80
  2. Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996;334(9):574-9
  3. Nobes JP, Langley SE, Klopper T, Russell-Jones D, Laing RW. A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy. BJU Int. 2012;109(10):1495-502
  4. Pantalone KM, Kattan MW, Yu C, Wells BJ, Arrigain S, Nutter B, et al. The risk of overall mortality in patients with Type 2 diabetes receiving different combinations of sulfonylureas and metformin: a retrospective analysis. Diabet Med. 2012;29(8):1029-35
  5. Bailey CJ. Diabetes: insulin plus metformin for T2DM--are there benefits? Nat Rev Endocrinol. 2012;8(8):449-50. [6] de Jager J, Kooy A, Lehert P, Wulffele MG, van der Kolk J, Bets D, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181
  6. Kumthekar AA, Gidwani HV, Kumthekar AB. Metformin associated B12 deficiency. J Assoc Physicians India. 2012;60:58- 60
  7. Sahin M, Tutuncu NB, Ertugrul D, Tanaci N, Guvener ND. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications. 2007;21(2):118-23
  8. Evatt ML, Terry PD, Ziegler TR, Oakley GP. Association between vitamin B12-containing supplement consumption and prevalence of biochemically defi•ned B12 defi•ciency in adults in NHANES III (third national health and nutrition examination survey). Public Health Nutr. 2010;13(1):25-31
  9. Langan RC, Zawistoski KJ. Update on vitamin B12 defi•ciency. Am Fam Physician. 2011;83(12):1425-30
  10. Andres E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, et al. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin defi•ciency. Clin Lab Haematol. 2006;28(1):50-6
  11. Andres E, Federici L, Sibilia J. Myelopathy in Sjogren's syndrome: a causative role for cobalamin (vitamin B12) deficiency. Drugs. 2006;66(5):729
  12. Federici L, Henoun Loukili N, Zimmer J, Affenberger S, Maloisel F, Andres E. [Update of clinical findings in cobalamin defi•ciency: personal data and review of the literature]. Rev Med Interne. 2007;28(4):225-31
  13. Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM. Ris