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Journals / Sakarya Tıp Dergisi / 2018 / Cilt: 8 - Sayı: 2

Tryptase and Chymase Expression Differences of Mast Cells in Prostatic Adencarcinomas

Prostatik Adenkarsinomlarda Mast Hücrelerinin Triptaz ve Kimaz Ekspresyon Farklılıkları

Handan ANKARALI
Ali ASLAN
Havva ERDEM
Feyza BAŞAR
Nilüfer KADIOĞLU
Hilal BALTA
Pages
229–234
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The research fi ndings were evaluated statistically and accepted as P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective Mast cells (MCs) have been shown to have various roles in many tumors.
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Key Findings & Data:The aim of this study was to investigate the presence and distribution of these two mast cell types in PCain terms of their tryptase and chymase content.( Sakarya Med J, 2018, 8(2):229-234 )Materials andMethodsIn this study, immunohistochemical analysis of tryptase and chymase expression was performed retrospectively in 134 patients who havediagnosed PCa histopathologically, at the Department of Pathology of Faculty of Medicine, **** University Educational Research Hospital,between 2012 and 2014.
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Conclusion & Impact:The research fi ndings were evaluated statistically and accepted as P
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective Mast cells (MCs) have been shown to have various roles in many tumors. MCs play roles in tumor progression via increasing angiogenesisand lymphangiogenesis. According to the presence of tryptase and chymase granules, mast cells are two varieties containing tryptasechymaseand containing tryptase. The aim of this study was to investigate the presence and distribution of these two mast cell types in PCain terms of their tryptase and chymase content.( Sakarya Med J, 2018, 8(2):229-234 )Materials andMethodsIn this study, immunohistochemical analysis of tryptase and chymase expression was performed retrospectively in 134 patients who havediagnosed PCa histopathologically, at the Department of Pathology of Faculty of Medicine, **** University Educational Research Hospital,between 2012 and 2014. Immunohistochemisrty experiment was done on the appropriate paraffi n blocks by using mast cell tryptase andchymase antibodies. The research fi ndings were evaluated statistically and accepted as P

Özet

Amaç Mast hücrelerinin (MCs) birçok tümörde çeşitli rolleri olduğu gösterilmiştir. MCs, artan anjiyogenez ve lenfogenez yoluyla tümör progresyonunda rol oynamaktadır. Triptaz ve kimaz granüllerinin varlığına göre mast hücreleri; triptaz- kimaz içeren ve triptaz içeren olmak üzere iki çeşittir. Bu çalışmanın amacı, içeriklerine göre farklı bu iki mast hücre tipinin prostatik adenokarsinomalardaki (PCa) varlığı ve dağılımını araştırmaktır.( Sakarya Tıp Dergisi, 2018, 8(2):229-234 ). Gereç ve Yöntem Bu çalışmada, 2012-2014 yılları arasında ***** Üniversitesi Tıp Fakültesi Eğitim Araştırma Hastanesi Patoloji Bölümü’nde histopatolojik olarak PCa tanısı alan 134 vakaya ait parafi n bloklar kullanıldı. Uygun parafi n bloklar seçilerek immunohistokimyasal olarak mast cell triptaz ve mast cell kimaz antikorları ile boyandı. Işık mikroskobunda pozitif boyanan mast hücreleri sayılarak değerlendirildi. İstatistiksel olarak değerlendirilen araştırma bulguları P

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Cite This Article

ANKARALI, H., ASLAN, A., ERDEM, H., BAŞAR, F., KADIOĞLU, N., BALTA, H. (2022). Tryptase and Chymase Expression Differences of Mast Cells in Prostatic Adencarcinomas. Sakarya Tıp Dergisi, Cilt: 8 - Sayı: 2, 229–234. https://ajindex.com/articles/590459

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