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Journals / Retina-Vitreus / 2022 / Cilt: 31 - Sayı: 3

Bilateral Uveitis and Papillitis During Metastatic Melanoma Treatment with Dabrafenib and Trametinib

Mehmet Serdar DERVİŞOĞULLARI
Pages
275–277
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients should be informed for the need of consecutive eye examinations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: To report a patient who developed bilateral uveitis and papillitis during dabrafenib and trametinib treatment for metastatic cutaneous melanoma.
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Key Findings & Data:Results: A patient under treatment for metastatic cutaneous melanoma with dabrafenib and trametinib presented to our clinic with 1 month of bilateral visual blurring complaint.
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Conclusion & Impact:Patients should be informed for the need of consecutive eye examinations.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: To report a patient who developed bilateral uveitis and papillitis during dabrafenib and trametinib treatment for metastatic cutaneous melanoma. Material and Methods: Retrospective chart review. Results: A patient under treatment for metastatic cutaneous melanoma with dabrafenib and trametinib presented to our clinic with 1 month of bilateral visual blurring complaint. At ophthalmological examination, bilateral uveitis and papillitis were observed. After stopping dabrafenib and trametinib and initiating topical steroid administration, intraocular inflammation and papillitis improved in 2 months. Final visual acuities were 20/20 in both eyes. Conclusion: Mitogen activated protein kinase (MAPK) inhibitors Dabrafenib anf trametinib can lead to ocular toxicity. Patients should be informed for the need of consecutive eye examinations.

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Cite This Article

DERVİŞOĞULLARI, M. S. (2022). Bilateral Uveitis and Papillitis During Metastatic Melanoma Treatment with Dabrafenib and Trametinib. Retina-Vitreus, Cilt: 31 - Sayı: 3, 275–277. https://ajindex.com/articles/589007

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