SavedAdd your journal

Journals / Nöropsikiyatri Arşivi / 2020 / Cilt: 57 - Sayı: 3

Electrophysiological Findings of Subclinical Lower Motor Neuron Involvement in Degenerative Upper Motor Neuron Diseases

Dejeneratif Üst Motor Nöron Hastalıklarında Subklinik Alt Motor Nöron Etkilenmesinin Elektrofizyolojik Bulguları

Elif KOCASOY ORHAN
Nermin Görkem ŞİRİN
Mehmet Barış BASLO
Hava Özlem DEDE
Halil Atilla İDRİSOĞLU
Pages
228–233
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Theratio of patients with an abnormal jitter study were higher in HSP group(60%) compared to PLS (22%) (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: The present study is an examination of possiblesubclinical involvement of lower motor neuron (LMN) in patients withprimary lateral sclerosis (PLS) and hereditary spastic paraparesis (HSP)electrophysiologically.Methods: Nine PLS patients and 5 HSP patients were prospectivelyanalyzed.
📊
Key Findings & Data:Jitter measurement with concentric needle electrode (25mm, 30 G) (CN-jitter) recorded from right extensor digitorum muscleduring voluntary contraction with 1 kHz high-pass frequency filter set.European Myelopathy Score (EMS) was used to evaluate disability.
💡
Conclusion & Impact:Theratio of patients with an abnormal jitter study were higher in HSP group(60%) compared to PLS (22%) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The present study is an examination of possiblesubclinical involvement of lower motor neuron (LMN) in patients withprimary lateral sclerosis (PLS) and hereditary spastic paraparesis (HSP)electrophysiologically.Methods: Nine PLS patients and 5 HSP patients were prospectivelyanalyzed. Jitter measurement with concentric needle electrode (25mm, 30 G) (CN-jitter) recorded from right extensor digitorum muscleduring voluntary contraction with 1 kHz high-pass frequency filter set.European Myelopathy Score (EMS) was used to evaluate disability. Therelationship between disability score and jitter values was investigated.Results: HSP patients had suffered from the disease for longer periodof time (p43 microseconds) observed in the PLS and HSP groups was 16/180and 9/100, respectively without a significant intergroup difference. Theratio of patients with an abnormal jitter study were higher in HSP group(60%) compared to PLS (22%) (p

Özet

Amaç: Bu çalışma primer lateral skleroz (PLS) ve herediter spastik paraparezi (HSP) hastalarında olası subklinik alt motor nöron (AMN) etkilenmesini elektrofizyolojik olarak incelemektedir. Yöntem: Dokuz PLS ve beş HSP hastası EMG laboratuvarında incelendi. Jitter ölçümü konsantrik iğne elektrot ile (25 mm, 30 G) sağ ekstansor digitorum kasından istemli kası sırasında alt kesim frekans filtresi 1 kHz olacak şekilde yapıldı. Özürlülüğü değerlendirmek için “European Myelopathy Score” kullanıldı. Özürlülük skoru ve jitter değerleri arasındaki ilişki incelendi. Bulgular: HSP hastalarının hastalık süreleri daha uzundu (p43 mikrosaniye) PLS ve HSP gruplarında sırasıyla 16/180 ve 9/100’idi. Anormal jitter sonuçları PLS ve HSP gruplarında 2/9 (%22) ve 3/5 (%60) olarak elde edildi (p

🔖

Cite This Article

ORHAN, E. K., ŞİRİN, N. G., BASLO, M. B., DEDE, H. Ö., İDRİSOĞLU, H. A. (2022). Electrophysiological Findings of Subclinical Lower Motor Neuron Involvement in Degenerative Upper Motor Neuron Diseases. Nöropsikiyatri Arşivi, Cilt: 57 - Sayı: 3, 228–233. https://ajindex.com/articles/584628

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Vucic S, Ziemann U, Eisen A, Hallett M, Kiernan MC. Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights. J Neurol Neurosurg Psychiatry 2013
  2. 1161–1170. [CrossRef] 2. Wais V, Rosenbohm A, Petri S, Kollewe K, Hermann A, Storch A, Hanisch F, Zierz S, Nagel G, Kassubek J, Weydt P, Brettschneider J, Weishaupt JH, Ludolph AC, Dorst J. The concept and diagnostic criteria of primary lateral sclerosis. Acta Neurol Scand 2017
  3. 204–211. [CrossRef] 3. Hudson AJ, Kiernan JA, Munoz DG, Pringle CE, Brown WF, Ebers GC. Clinicopathological features of primary lateral sclerosis are different from amyotrophic lateral sclerosis. Brain Res Bull 1993
  4. 359–364. [CrossRef] 4. Schule R, Wiethoff S, Martus P, Karle KN, Otto S, Klebe S, Klimpe S, C Gallenmüller, Kurzwelly D, Henkel D, Rimmele F, Stolze H, Kohl Z, Kassubek J, Klockgether T, Vielhaber S, Kamm C, Klopstock T, Bauer P, Züchner S, Scarfone IL, Schöls L. Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients. Ann Neurol 2016
  5. 646–658. [CrossRef] 5. McDermott CJ, Burness CE, Kirby J, Cox LE, Rao DG, Hewamadduma C, Sharrack B, Hadjivassiliou M, Chinnery PF, Dalton A, Shaw PJ
  6. UK and Irish HSP Consortium. Clinical features of hereditary spastic paraplegia due to spastin mutation. Neurology 2006
  7. 45–51. [CrossRef] 6. Brugman F, Veldink JH, Franssen H, de Visser M, de Jong JM, Faber CG, Kremer BH, Schelhaas HJ, van Doorn PA, Verschuuren JJ, Bruyn RP, Kuks JB, Robberecht W, Wokke JH, van den Berg LH. Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromes. Arch Neurol 2009
  8. 509–514. [CrossRef] 7. Deluca GC, Ebers GC, Esiri MM. The extent of axonal loss in the long tracts in hereditary spastic paraplegia. Neuropathol Appl Neurobiol 2004
  9. 576– 584. [CrossRef] 8. Sanders DB, Stalberg EV. AAEM minimonograph #25: single-fiber electromyography. Muscle Nerve 1996
  10. 1069–1083. [CrossRef] 9. Cui LY, Liu MS, Tang XF. Single fiber electromyography in 78 patients with amyotrophic lateral sclerosis. Chin Med J (Engl) 2004
  11. 1830–1833. 10. Cherian A, Baheti NN, Iype T. Electrophysiological study in neuromuscular junction disorders. Ann Indian Acad Neurol 2013
  12. 34–41. [CrossRef] 11. Sanders DB, Howard JF Jr. AAEE minimonograph #25: Single-fiber electromyography in myasthenia gravis. Muscle Nerve 1986
  13. 809–819. [CrossRef] 12. Selvan VA. Single-fiber EMG. A review. Ann Indian Acad N