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Journals / Mugla Journal of Science and Technology / 2022 / Cilt: 8 - Sayı: 1

CYTOTOXICITY AND WOUND HEALING CAPACITY OF BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES

BİYOLOJİK OLARAK SENTEZLENMİŞ GÜMÜŞ NANOPARTİKÜLLERİN SİTOTOKSİSİTESİ VE YARA İYİLEŞTİRME KAPASİTESİ

Tuba BAYGAR
Aysel UĞUR
Nurdan SARAÇ
Pages
63–68
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It can be suggested that biologically synthesized AgNPs can be used effectively for biomedical applications such as wound dressing materials.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Metallic nanoparticles are interesting areas of research due to their unique properties which can be advantageous for producing smart products.
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Key Findings & Data:Cytotoxicity of the biogenic AgNPs was determined by MTT (3- [4, 5- dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium-bromide) assay against L929 fibroblast cell line.
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Conclusion & Impact:It can be suggested that biologically synthesized AgNPs can be used effectively for biomedical applications such as wound dressing materials.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:silver nanoparticle · green synthesis · cytotoxicity

Abstract

Metallic nanoparticles are interesting areas of research due to their unique properties which can be advantageous for producing smart products. Silver nanoparticles (AgNPs) are remarkably used in pharmaceutical industry because of their strong biological activities. The aim of the present study was to investigate the cytotoxicity and wound healing capacity of the biologically prepared silver nanoparticles via green synthesis route. Cytotoxicity of the biogenic AgNPs was determined by MTT (3- [4, 5- dimethyl-2-thiazolyl]-2, 5-diphenyl-2H-tetrazolium-bromide) assay against L929 fibroblast cell line. Wound healing properties of the AgNPs were evaluated using in vitro-scratch wound healing assay using 3T3 fibroblast cell line. Biosynthesized AgNPs inhibited the propagation of fibroblasts at a half maximal inhibitory concentration (IC50) of 23.507 μg/mL after 24 h incubation. In vitro wound healing assay also revealed that the biogenic AgNPs stimulated the 3T3 fibroblasts' cell proliferation. It can be suggested that biologically synthesized AgNPs can be used effectively for biomedical applications such as wound dressing materials.

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Cite This Article

BAYGAR, T., UĞUR, A., SARAÇ, N. (2022). CYTOTOXICITY AND WOUND HEALING CAPACITY OF BIOLOGICALLY SYNTHESIZED SILVER NANOPARTICLES. Mugla Journal of Science and Technology, Cilt: 8 - Sayı: 1, 63–68. https://ajindex.com/articles/581858

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