SavedAdd your journal

Journals / Molecular Imaging and Radionuclide Therapy / 2020 / Cilt: 29 - Sayı: 1

Hepatopulmonary Syndrome with Right-to-left Shunt in Cirrhotic Patients Using Macro-Aggregated Albumin Lung Perfusion Scan: Comparison with Contrast Echocardiography and Association with Clinical Data

Sirotik Hastalardaki Sağ-Sol Şant ile İlişkili Hepatopulmoner Sendromun Tanısında MakroAgregant Albümin Akciğer Perfüzyon Sintigrafisinin Kontrast Ekokardiyografi ile Karşılaştırılması ve Klinik Veriler ile İlişkisi

Ali GHOLAMREZANEZHAD
Seyed Masoud TABİB
Zahra AZİZMOHAMMADİ
Majid ASSADİ
Zeynab ALİPOUR
Abbas ARMİN
Sudabeh MOHAMADİ
Pages
1–6
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Among coagulation factors assessed in cirrhotic patients, we found only significant correlation between HPS and prothrombin time (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The diagnosis of hepatopulmonary syndrome (HPS) which is a common complication in cirrhotic patients is still subject to debate.
📊
Key Findings & Data:This study investigated the association of clinical findings with HPS in cirrhotic patients using macro-aggregated albumin lung perfusion scan (99mTcMAA lung scintigraphy).
💡
Conclusion & Impact:Among coagulation factors assessed in cirrhotic patients, we found only significant correlation between HPS and prothrombin time (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The diagnosis of hepatopulmonary syndrome (HPS) which is a common complication in cirrhotic patients is still subject to debate. This study investigated the association of clinical findings with HPS in cirrhotic patients using macro-aggregated albumin lung perfusion scan (99mTcMAA lung scintigraphy). In addition, comparison between 99mTc-MAA lung scintigraphy and contrast echocardiography (CEE) in detection of HPS was also performed. Methods: In this study, 27 patients with cirrhosis underwent 99mTc-MAA lung scintigraphy and contrast echocardiography comparison CEE and the frequency of HPS was assessed in them and also was compared across the other variables. Results: The 99mTc-MAA lung scintigraphy showed HPS in 13 patients (48.1%) while CEE demonstrated HPS in 5 patients with cirrhosis (18.51%). HPS was mild in 40.74% (11/27) of the patients, and severe in only 2 patients. There was no relationship between gender, disease duration, having diagnosis of disease previously, pulmonary symptoms and Child-Pugh score variations and HPS (p>0.05). Comparison of hemodynamic indices, arterial blood gas analysis and laboratory indices between patients with and without HPS was also non-significant (p value >0.05). Among coagulation factors assessed in cirrhotic patients, we found only significant correlation between HPS and prothrombin time (p

Özet

Amaç: Sirotik hastalarda sık görülen bir komplikasyon olan hepatopulmoner sendromun (HPS) tanısı halen tartışmaya açıktır. Bu çalışmada, makroagregat albümin akciğer perfüzyon sintigrafisi (99mTc-MAA akciğer sintigrafisi) kullanılarak sirotik hastalarda klinik bulgularla HPS’nin ilişkisi araştırılmıştır. Ayrıca, HPS’nin saptanmasında 99mTc-MAA akciğer sintigrafisi ile kontrast ekokardiyografi (KE) karşılaştırılmıştır. Yöntem: Bu çalışmada, sirozlu 27 hastada 99mTc-MAA akciğer sintigrafisi ve KE karşılaştırıldı ve HPS sıklığı değerlendirildi. Ayrıca HPS’nin sıklığı ile diğer değişkenler arasındaki ilişki araştırıldı. Bulgular: 99mTc-MAA akciğer sintigrafisi 13 sirozlu hastada (%48,1) HPS’nin varlığını gösterirken, KE 5 sirozlu hastada (%18,51) gösterdi. HPS hastaların %40,74’inde (11/27) hafif, sadece 2 hastada şiddetliydi. Cinsiyet, hastalık süresi, hastalık geçmişi, akciğer semptomları ve Child skoru ile HPS arasında herhangi bir ilişki yoktu (p>0,05). Hemodinamik indeksler, arteriyel kan gazı analizi ve laboratuvar indeksleri açısından HPS’li hastalar ve HPS’li olmayan hastalar arasında fark görülmedi (p>0,05). Sirotik hastalarda değerlendirilen koagülasyon faktörleri arasında, sadece HPS ve protrombin zamanı arasında anlamlı bir korelasyon bulundu (p

🔖

Cite This Article

GHOLAMREZANEZHAD, A., TABİB, S. M., AZİZMOHAMMADİ, Z., ASSADİ, M., ALİPOUR, Z., ARMİN, A., MOHAMADİ, S. (2022). Hepatopulmonary Syndrome with Right-to-left Shunt in Cirrhotic Patients Using Macro-Aggregated Albumin Lung Perfusion Scan: Comparison with Contrast Echocardiography and Association with Clinical Data. Molecular Imaging and Radionuclide Therapy, Cilt: 29 - Sayı: 1, 1–6. https://ajindex.com/articles/581575

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Lima BL, França AV, Pazin-Filho A, Araújo WM, Martinez JA, Maciel BC, Simões MV, Terra-Filho J, Martinelli AL. Frequency, clinical characteristics, and respiratory parameter of hepatopulmonay Syndrome. Mayo Clin Proc 2004;79:42-48.
  2. Schen KP, Falrmaannn V, Madl C, Funk G, Lehr S, Kandel O, Müller C. Hepatopulmonary syndrome: prevalence and predictive value of various cut off for arterial oxygenation and their clinical consequences. Gut 2002;51:853-859.
  3. Hira HS, Kumaj T, Tyagi SK, Jain SK. A study of hepatopulmonary syndrome among patient of cirrhosis of liver and portal hypertension. Indian J Chest Dis Allied Sci 2003;45:165-171.
  4. Anond AC, Malcheryee D, Rao KS, Seth AK. Hepatopulmonary syndrome; prevalence and clinical profile. Indian J Gastroenterol 2001;20:24-27.
  5. Fallon MB, Abrams GA. Pulmonary dysfunction in chronic disease. Hepatology 2000;32:859-865.
  6. Przybyowski T, Krenke R, Fangrat A, Nasilowski J, Grabczak EM, Styczynskg G, Pruszczyk P, Krawczyk M, Chazan R. Gas exchange abnormalities in patients listed forliver transplantation. J Physiol Pharmacol 2006;57 Suppl 4:313-323. Flukiger M. Occurrence of club-shaped finger phalanges without chronicchanges in the lungs or heart. Wien Med Wochenschr 1884;34:1457-1458.
  7. Rodriguez-Roisin R, Krowka MJ, Herve P, Fallon MB. Pulmonary hepatic vascular disorders (PHD). Eur Respir J 2004; 24:861-80.
  8. Abrams GA, Jaffe CC, Hoffer PB, Binder HJ, Fallon MB. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology 1995;109:1283-1288. 10. Abrams GA, Nanda NC, Dubovsky EV, Krowka MJ, Fallon MB. Use of macro-aggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach. Gastroenterology 1998;114:305-310. 11. Gupta NA, Abramowsky C, Pillen T, Redd D, Fasola C, Heffron T, Romero R. Pediatric hepatopulmonarys Syndrome is seen with polysplenia/ interrupted inferior vena cava and without cirrhosis. Liver Transpl 2007;13:680-686. 12. Swanson KL,Wiesner RH, Krowka MJ. Natural history of hepatopulmonary syndrome: impact of liver transplantation. Hepatology 2005;41:11221129. 13. Noli K, Solomon M, Golding F, Charron F, Ling SC. Prevalence of hepatopulmonary syndrome in children. Pediatrics 2008;121:522-527. 14. Surasi DS, Manapragada P, Bhambhvani P. Lung perfusion imaging in hepatopulmonary syndrome using (99m)Tc macroaggregated albumin. J Nucl Cardiol 2015;22:586-588. 15. El-Shabrawi MH, Omran S, Wageeh S, Isa M, Okasha S, Mohsen