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Journals / Molecular Imaging and Radionuclide Therapy / 2020 / Cilt: 29 - Sayı: 2

The Predictive Value of Proportional Evaluation Based on the Metabolic Activity of Cervical Lymph Nodes on PET/CT Imaging in Patients with Larynx Cancer

Larinks Kanserli Hastalarda PET/BT Görüntülemede Servikal Lenf Nodlarının Metabolik Aktivitesine Dayanan Oransal Değerlendirmenin Prediktif Değeri

Sevda SAĞLAMPINAR KARYAĞAR
Savaş KARYAĞAR
Osman GÜVEN
Onur ÜSTÜN
Yavuz ATAR
Yavuz UYAR
Pages
59–64
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVmaxLN;79.7%, 84%, 1.78 for SUVmaxLN/SUVmaxA; 84.1%, 76%, 0.833 for SUVmaxLN/SUVmaxL; and 53.6%, 76%, 0.666 for SUVmaxLN/SUVmaxPT, respectively.Conclusion: SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.

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Objective & Hypothesis:Objectives: We aimed to evaluate the proportional values of maximum standardized uptake value (SUVmax) for cervical lymph nodes on18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis inpatients with larynx squamous cell cancer (LSCC).Methods: This retrospective study involved 43 patients with LSCC.
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Key Findings & Data:All patients underwent resection of the primary tumor and neck dissectionwithin 4 weeks after undergoing 18F-FDG PET/CT examinations.
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Conclusion & Impact:The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVmaxLN;79.7%, 84%, 1.78 for SUVmaxLN/SUVmaxA; 84.1%, 76%, 0.833 for SUVmaxLN/SUVmaxL; and 53.6%, 76%, 0.666 for SUVmaxLN/SUVmaxPT, respectively.Conclusion: SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: We aimed to evaluate the proportional values of maximum standardized uptake value (SUVmax) for cervical lymph nodes on18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for prediction of the presence of metastasis inpatients with larynx squamous cell cancer (LSCC).Methods: This retrospective study involved 43 patients with LSCC. All patients underwent resection of the primary tumor and neck dissectionwithin 4 weeks after undergoing 18F-FDG PET/CT examinations. Receiver operating characteristic (ROC) analysis was performed to evaluate thelymph node SUVmax/primary tumor SUVmax (SUVmaxLN/SUVmaxPT), lymph node SUVmax/aortic SUVmax (SUVmaxLN/SUVmaxA), and lymph node SUVmax/liver SUVmax (SUVmaxLN/ SUVmaxL) ratios for diagnosis of lymph node metastasis.Results: SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT rates were significantly higher in metastatic lymph nodes compared tonon-metastatic nodes. ROC analysis for metastasis showed that the cut-off thresholds were 3.87 for SUVmaxLN; 1.78 for SUVmaxLN /SUVmaxA; 1.08for SUVmaxLN/SUVmaxL; and 0.36 for SUVmaxLN/SUVmaxPT. The diagnostic sensitivity, specificity and AUC were 83.7%, 77%, 0.856 for SUVmaxLN;79.7%, 84%, 1.78 for SUVmaxLN/SUVmaxA; 84.1%, 76%, 0.833 for SUVmaxLN/SUVmaxL; and 53.6%, 76%, 0.666 for SUVmaxLN/SUVmaxPT, respectively.Conclusion: SUVmaxLN/SUVmaxA, SUVmaxLN/SUVmaxL, and SUVmaxLN/SUVmaxPT ratios can be safely used for diagnosis of cervical lymph node metastasis in patients with LSCC.

Özet

Amaç: 18F-florodeoksiglikoz (FDG) pozitron emisyon tomografisi/bilgisayarlı tomografide (PET/BT) servikal lenf nodlarının maksimum standardize uptake değerine (SUVmaks) dayalı oransal değerlerin skuamöz hücreli larenks kanserli (LSHK) hastalarda metastaz varlığını tahmin etmedeki gücünü değerlendirmeyi amaçladık. Yöntem: Bu retrospektif çalışmaya LSHK olan 43 hasta alındı. Tüm hastalara 18F-FDG PET/BT görüntülemeden sonraki 4 hafta içinde primer tümör rezeksiyonu ve boyun diseksiyonu yapıldı. Metastatik lenf nodlarının tanısı açısından lenf nodu SUVmaks/primer tümör SUVmaks (SUVmaksLN/ SUVmaksPT), lenf nodu SUVmaks/aortik SUVmaks (SUVmaksLN/SUVmaksA), lenf nodu SUVmaks/karaciğer SUVmaks (SUVmaksLN/SUVmaksL) oranları alıcı işletim karakteristiği (ROC) analizi yapılarak değerlendirildi. Bulgular: SUVmaksLN/SUVmaksA, SUVmaksLN/SUVmaksL, SUVmaksLN/SUVmaksPT oranları metastatik lenf nodlarında metastatik olmayanlara göre anlamlı derecede yüksek idi. ROC analizinde metastaz tespiti açısından eşik değerler, SUVmaxLN için 3,87; SUVmaksLN/SUVmaksA için 1,78; SUVmaksLN/ SUVmaksL için 1,08; SUVmaksLN/SUVmaxPT için 0,36 olarak bulundu. Tanısal duyarlılık, özgüllük ve AUC değerleri SUVmaksLN, SUVmaksLN/SUVmaksA, SUVmaksLN/SUVmaksL, SUVmaksLN/SUVmaksPT için sırasıyla %83,7, %77, 0,856; %79,7, %84, 1,78; %84,1, %76, 0,833; %53,6, %76, 0,666 idi. Sonuç: SUVmaksLN/SUVmaksA, SUVmaksLN/SUVmaksL, SUVmaksLN/SUVmaksPT oranları, LSHK hastalarında metastatik servikal lenf nodlarının tanısında güvenle kullanılabilir.

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Cite This Article

KARYAĞAR, S. S., KARYAĞAR, S., GÜVEN, O., ÜSTÜN, O., ATAR, Y., UYAR, Y. (2022). The Predictive Value of Proportional Evaluation Based on the Metabolic Activity of Cervical Lymph Nodes on PET/CT Imaging in Patients with Larynx Cancer. Molecular Imaging and Radionuclide Therapy, Cilt: 29 - Sayı: 2, 59–64. https://ajindex.com/articles/581571

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