The -1993 T>C polymorphismof TBX21 may play a role in the etiopathogenesis of the NP.
📌 3 Key Takeaways
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Objective & Hypothesis:Objectives: This study aims to investigate the possiblerelationship between nasal polyposis (NP) and transcription genefamily (T-box) promoter region gene (TBX21) polymorphism.Patients and Methods: This retrospective studyincluded a total of 32 patients (23 males, 9 females;mean age 42.5±15.0 years; range, 18 to 83 years) who werepreviously operated or given medical treatment for NP(Group 1) and 50 healthy controls (21 males, 29 females;mean age 32.7±9.9 years; range, 18 to 83 years) with a negativemulti-prick allergy test result without any nasal cavitypathology (Group 2) between July 2018 and September 2018.The -1993 T>C single nucleotide polymorphism (SNP) in theTBX21 promoter region was investigated in all participants.Results: The number of TBX21 heterozygous mutation carrierswas statistically significantly higher in Group 1 (p=0.001).In Group 1, allele mutation positivity with an allergy historywas significantly higher than those without allergy history(p=0.028).Conclusion: We found a higher ratio of TBX21 heterozygousmutation in the patients with NP.
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Key Findings & Data:Objectives: This study aims to investigate the possiblerelationship between nasal polyposis (NP) and transcription genefamily (T-box) promoter region gene (TBX21) polymorphism.Patients and Methods: This retrospective studyincluded a total of 32 patients (23 males, 9 females;mean age 42.5±15.0 years; range, 18 to 83 years) who werepreviously operated or given medical treatment for NP(Group 1) and 50 healthy controls (21 males, 29 females;mean age 32.7±9.9 years; range, 18 to 83 years) with a negativemulti-prick allergy test result without any nasal cavitypathology (Group 2) between July 2018 and September 2018.The -1993 T>C single nucleotide polymorphism (SNP) in theTBX21 promoter region was investigated in all participants.Results: The number of TBX21 heterozygous mutation carrierswas statistically significantly higher in Group 1 (p=0.001).In Group 1, allele mutation positivity with an allergy historywas significantly higher than those without allergy history(p=0.028).Conclusion: We found a higher ratio of TBX21 heterozygousmutation in the patients with NP.
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Conclusion & Impact:The -1993 T>C polymorphismof TBX21 may play a role in the etiopathogenesis of the NP.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters
Abstract
Objectives: This study aims to investigate the possiblerelationship between nasal polyposis (NP) and transcription genefamily (T-box) promoter region gene (TBX21) polymorphism.Patients and Methods: This retrospective studyincluded a total of 32 patients (23 males, 9 females;mean age 42.5±15.0 years; range, 18 to 83 years) who werepreviously operated or given medical treatment for NP(Group 1) and 50 healthy controls (21 males, 29 females;mean age 32.7±9.9 years; range, 18 to 83 years) with a negativemulti-prick allergy test result without any nasal cavitypathology (Group 2) between July 2018 and September 2018.The -1993 T>C single nucleotide polymorphism (SNP) in theTBX21 promoter region was investigated in all participants.Results: The number of TBX21 heterozygous mutation carrierswas statistically significantly higher in Group 1 (p=0.001).In Group 1, allele mutation positivity with an allergy historywas significantly higher than those without allergy history(p=0.028).Conclusion: We found a higher ratio of TBX21 heterozygousmutation in the patients with NP. The -1993 T>C polymorphismof TBX21 may play a role in the etiopathogenesis of the NP.
Özet
Amaç: Bu çalışmada nazal polipozis (NP) ve transkripsiyon gen ailesi (T-box) promotör bölgesi gen (TBX21) polimorfizmi arasında muhtemel ilişki araştırıldı. Hastalar ve Yöntemler: Bu retrospektif çalışmaya Temmuz 2018 - Eylül 2018 tarihleri arasında daha önce NP nedeniyle ameliyat edilen veya tıbbi tedavi verilen 32 hasta (Grup 1) (23 erkek, 9 kadın; ort. yaş 42.5±15.0 yıl; dağılım, 18-83 yıl) ve multi-prick alerji test sonucu negatif olan ve herhangi bir nazal kavite patolojisi olmayan 50 sağlıklı kontrol (Grup 2) (21 erkek, 29 kadın; ort. yaş 32.7±9.9 yıl; dağılım, 18-83 yıl) dahil edildi. Tüm katılımcılarda TBX21 promotör bölgesinde -1993 T>C tek nükleotidli polimorfizm (SNP) araştırıldı. Bulgular: TBX21 heterozigot mutasyon taşıyıcı sayısı, Grup 1’de istatistiksel olarak anlamlı düzeyde daha yüksekti (p=0.001). Grup 1’de alerji öyküsü olmayanlara kıyasla alerji öyküsü olanlarda alel mutasyon pozitifliği anlamlı düzeyde daha yüksekti (p=0.028). Sonuç: TBX21 heterozigot mutasyon oranı NP’li hastalarda daha yüksek bulundu. TBX21’in -1993 T>C polimorfizmi, NP’nin etiyopatogenezinde rol oynayabilir.
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Cite This Article
0000-0002-6688-2347, 0., Toros, S. Z., Ertugay, Ö. Ç., Külekçi, S., Kaya, K. S. (2022). Association of TBX21 gene polymorphism with nasal polyposis. Kulak Burun Boğaz Uygulamaları, Cilt: 7 - Sayı: 3, 145–150. https://ajindex.com/articles/576543
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