Journals / Koşuyolu Kalp Dergisi / 2017 / Cilt: 20 - Sayı: 1

İdiyopatik Perikardiyal Efüzyon ile İnflamatuvar Belirteçler Arasındaki İlişki

The Relation of Inflammatory Markers to Idiopathic Pericardial Effusion

Pages
53–58
Publication Date
2022-10-18
DOI
—
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In the multivariate logistic regression modelNLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) and hs-CRP (OR 1.090, 95% CI 1.030-1.152; p= 0.003)remained as independent predictors of severe PE in patients who have PE.Conclusion: hs-CRP, NLR and PLR may be used for disease activity monitoring, treatment responseevaluation and risk stratification of patients with PE.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: With the growing evidence about the role of inflammation on cardiovascular disorders, studieshave been focused on inflammatory markers for risk evaluation and disease activity monitoring.
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Key Findings & Data:The aim ofthis study was to investigate whether inflammation has a role in idiopathic pericardial effusion (PE) and toreveal its correlation with the disease activity.Patients and Methods: The study population consisted of 107 patients with PE and 35 age-matched andsex-matched healthy volunteers.
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Conclusion & Impact:In the multivariate logistic regression modelNLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) and hs-CRP (OR 1.090, 95% CI 1.030-1.152; p= 0.003)remained as independent predictors of severe PE in patients who have PE.Conclusion: hs-CRP, NLR and PLR may be used for disease activity monitoring, treatment responseevaluation and risk stratification of patients with PE.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: With the growing evidence about the role of inflammation on cardiovascular disorders, studieshave been focused on inflammatory markers for risk evaluation and disease activity monitoring. The aim ofthis study was to investigate whether inflammation has a role in idiopathic pericardial effusion (PE) and toreveal its correlation with the disease activity.Patients and Methods: The study population consisted of 107 patients with PE and 35 age-matched andsex-matched healthy volunteers. Each patient underwent a comprehensive clinical evaluation to identify theprobable underlying systemic diseases or other potential causes for PE.Results: High-sensitivity C-reactive protein levels (hs-CRP), neutrophil/lymphocyte ratio (NLR) andplatelet/lymphocyte ratio (PLR) (p< 0.001 for each) were significantly higher in the PE group than in healthyvolunteers. The patients with PE were divided into three subgroups according to the amount of PE. hs-CRP,NLR and PLR significantly correlated with the amount of PE. In the multivariate logistic regression modelNLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) and hs-CRP (OR 1.090, 95% CI 1.030-1.152; p= 0.003)remained as independent predictors of severe PE in patients who have PE.Conclusion: hs-CRP, NLR and PLR may be used for disease activity monitoring, treatment responseevaluation and risk stratification of patients with PE.

Özet

Giriş: İnflamasyonun kardiyovasküler hastalıklardaki rolü hakkındaki kanıtların gittikçe artmasıyla, çalışmalarinflamatuvar markerların hastalık aktivitesi ve risk değerlendirmesindeki rolüne odaklanmıştır. Bu çalış-manın amacı inflamatuvar belirteçlerin idiyopatik perikardiyal efüzyonla ile ilişkisini ve hastalık aktivitesi ileolan korelasyonu olup olmadığının incelenmesidir.Hastalar ve Yöntem: Çalışma popülasyonu perikardiyal efüzyonu olan 107 hasta ile yaş ve cinsiyet olarakbenzer 35 sağlıklı gönüllülerden oluşmaktadır. Tüm hastalar perikardiyal efüzyonun etyolojisine yönelik kapsamlıbir klinik değerlendirmeye tabi tutulmuştur.Bulgular: Plevral efüzyonu grubunda, yüksek sensitif C-reaktif protein (Hs-CRP), nötrofil/lenfosit oranı(NLR) ve platelet/lenfosit oranı (PLR) (herbiri için p< 0.001), sağlıklı gönüllülerin grubuna göre anlamlıolarak daha yüksekti. Perikardiyal efüzyonu olan hastalar efüzyon miktarına göre 3 gruba bölündü. Hs-CRP,NLR ve PLR perikardiyal efüzyon miktarıyla korele bir şekilde artmaktadır. Çoklu analizde, NLR (OR 1.363,95% CI 1.026-1.809; p= 0.033) ve Hs-CRP (OR 1.090, %95 CI 1.030-1.152; p= 0.003), perikardiyal efüzyonuolan hastalarda ciddi perikardiyal efüzyonun bağımsız bir prediktörleridir.Sonuç: Hs-CRP, NLR ve PLR perikardiyal efüzyonu olan hastalarda, hastalık aktivitesi, tedavi monitörizasyonundave risk sınıflamasında kullanılabilir.

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Cite This Article

GÜNGÖR, H., ELBİ, H., BEKTAŞ, H., ZENCİR, C., AKGÜLLÜ, Ç., KAHRAMAN, K., SELVİ, M., ÖNAY, S., AKPEK, M., YILMAZ, M., ÇETİN, M. (2022). İdiyopatik Perikardiyal Efüzyon ile İnflamatuvar Belirteçler Arasındaki İlişki. Koşuyolu Kalp Dergisi, Cilt: 20 - Sayı: 1, 53–58. https://ajindex.com/articles/576053

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