Journals / Koşuyolu Heart Journal / 2014 / Cilt: 17 - Sayı: 3

İzole aort kapak replasmanı yapılan hastalarda postoperatif beyaz küre artışı mortalite belirtecidir

Acute increase in postoperative white cell count predicts mortality in ısolated aortic valve replacement patients

Pages
163–166
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Acute increase in white cell count after aortic valve replacement procedure is associated with mortality.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Inflammatory reaction after cardiac surgery is well documented.
📊
Key Findings & Data:In this study, we aimed to investigate association with acute increase in white blood cell count after cardiopulmonary bypass with mortality.
💡
Conclusion & Impact:Conclusion: Acute increase in white cell count after aortic valve replacement procedure is associated with mortality.
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Inflammatory reaction after cardiac surgery is well documented. In this study, we aimed to investigate association with acute increase in white blood cell count after cardiopulmonary bypass with mortality. Patients and Methods: We included 35 patients with isolated aortic valve replacement procedure with cardiopulmonary bypass during time phrase June 2009 to July 2013. Blood sampled the day before the operation and on postoperative 24th hour. White blood cell counted and preoperative postoperative difference was calculated. Results: Total 35 patients were included to study. Four-teen (40%) of them were female. Mean age of patients was 61.14±13.25. Mortality observed patients had two fold increase in mean white blood cell count (preoperative/ postoperative white blood cell count 4.971±1.11/ 8.19±3.47 p=0.03 95% CI 1.88-8.06/3.88-12.50). Conclusion: Acute increase in white cell count after aortic valve replacement procedure is associated with mortality.

Özet

Giriş: Kalp cerrahisi sonrası inflamatuvar reaksiyon iyi dokümante edilmiştir. Bu çalışmada, kardiyopulmoner bypass sonrası beyaz kan hücrelerinde akut artış ile mortalite arasındaki ilişkiyi incelemeyi amaçladık. Hastalar ve Yöntem: Haziran 2009-Temmuz 2013 arasında kardiyopulmoner bypass eşliğinde izole aort kapak replasmanı uygulanan 35 hasta çalışmaya dahil edildi. Kan örnekleri operasyondan önceki gün ve postoperatif 24. saatte alındı. Beyaz kan hücreleri sayıldı ve operasyon öncesi ve sonrası değerler hesaplandı. Bulgular: Toplam 35 hasta çalışmaya alındı. On dört tanesi (40%) kadındı. Ortalama yaş 61,14±13,25 idi. Mortalite izlenen hastalarda beyaz kan hücresi sayısında iki kat artış olduğu görüldü (preoperatif-postoperatif beyaz hücre sayıları 4,971±1,11/ 8,19±3,47 p=0,03 95% CI 1,88-8,06/3,88-12,50). Sonuç: Aort kapak replasmanı sonrası beyaz kan hücrelerinin akut artışı mortalite ile ilişkilidir.

🔖

Cite This Article

KARACA, O. G., SALİHİ, S., KALENDER, M., ECEVİT, A. N., TAŞAR, M., BAYSAL, A. N. (2022). İzole aort kapak replasmanı yapılan hastalarda postoperatif beyaz küre artışı mortalite belirtecidir. Koşuyolu Heart Journal, Cilt: 17 - Sayı: 3, 163–166. https://ajindex.com/articles/575977

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pacifico AD. Complement and the damaging effect of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1983
  2. Edmunds LH Jr. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 1998
  3. Menasche P, Edmunds LH Jr. Extracorporeal circulation: the inflammatory response. In: Cohn LH, Edmunds LH Jr, eds. Cardiac Surgery in the Adult. New York: McGraw-Hill 2003:349-60. 4.Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. British Journal of Anaesthesia 1997
  4. Giannoudis P, Dinopoulos H, Chalidis B, Hall G. Surgical stress response. Injury, Int. J. Care Injured 2006
  5. Okamura T, Ishibashi N, Zurakowski D, Jonas RA. Cardiopulmonary bypass increases permeability of the blood cerebrospinal fluid barrier. Ann Thorac Surg 2010
  6. Breda MA, Drinkwater DC, Laks H, Bhuta S, Corno AF, Davtyan HG, et. al. Prevention of reperfusion injury in the neonatal heart with leukocyte- depleted blood. J Thorac Cardiovasc Surg 1989
  7. Byrne JG, Appleyard RF, Lee CC, Couper GS, Scholl FG, Laurence RG, et. al. Controlled reperfusion of the regionally ischemic myocardium with leukocyte-depleted blood reduces stunning, the no-reflow phenomenon, and infarct size. J Thorac Cardiovasc Surg 1992
  8. Bando K, Pillai R, Cameron DE, Brawn JD, Winkelstein JA, Hutchins GM, et.al. Leukocyte depletion ameliorates free radical-mediated lung injury after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1990
  9. Bechtel JF, Mühlenbein S, Eichler W, Marx M, Sievers HH. Leukocyte depletion during cardiopulmonary bypass in routine adult cardiac surgery. Interact Cardiovasc Thorac Surg 2011
  10. Emiroğulları NÖ, Aşgün F, Kahraman C, Taşdemir K, Ceyran H, Serhatlıoğlu F, ve ark. The influence of leukocyte filtration during cardiopulmonary bypass on early postoperative myocardial function. Turk Gogus Kalp Dama 2008
  11. Sürer S, Bolat A, Koç M, Gülbahar O, Kutsal A. Investigation of the effects of leukocyte filtration in congenital heart surgery. Turk Gogus Kalp Dama 2014
  12. Beilin B, Shavit Y, Trabekin E, Mordashev B, Mayburd E, Zeidel A, et al. The effects of postoperative pain management on immune response to surgery. Anesth Analg 2003
  13. Scholl R, Bekker A, Babu R. Neuroendocrine and Immune Responses to Surgery. The Internet Journal of Anesthesiology. 2012 Volume 30 Numb