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Journals / Türk Göğüs Kalp Damar Cerrahisi Dergisi / 2015 / Cilt: 23 - Sayı: 1

Amiodaronun koroner arter baypas greftleri üzerine in vitro etkileri

In vitro effects of amiodarone on coronary artery bypass grafts

Özcan GÜR
Okay Güven KARACA
Çetin Hakan KARADAĞ
Suat CANBAZ
Mehmet KALENDER
Ata Niyazi ECEVİT
Turan EGE
Pages
14–18
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results:­ Amiodarone caused relaxation in all grafts (ITA,RA, SV) between 10-9-10-3,5 M concentration in a dosedependent manner (p

📌 3 Key Takeaways

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Objective & Hypothesis:Background:­ This study aims to investigate the effects ofamiodarone on the most commonly used grafts, internalthoracic artery (ITA), saphenous vein (SV), and radialartery (RA) in organ bath.
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Key Findings & Data:Methods: Twenty patients (16 males, 4 females; meanages 58.4±9.9 years; range 38 to 80 years) who underwentisolated coronary artery bypass graft (CABG) surgerybetween May 2008 and October 2008 were included inthis study.
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Conclusion & Impact:Results:­ Amiodarone caused relaxation in all grafts (ITA,RA, SV) between 10-9-10-3,5 M concentration in a dosedependent manner (p
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:Domain Parameters

Abstract

Background:­ This study aims to investigate the effects ofamiodarone on the most commonly used grafts, internalthoracic artery (ITA), saphenous vein (SV), and radialartery (RA) in organ bath. Methods: Twenty patients (16 males, 4 females; meanages 58.4±9.9 years; range 38 to 80 years) who underwentisolated coronary artery bypass graft (CABG) surgerybetween May 2008 and October 2008 were included inthis study. Internal thoracic artery, saphenous vein, andradial artery grafts were harvested. Specimens were takento laboratory in +4 ºC Krebs solution. Specimens weresuspended in 10 ml organ bath containing Krebs solution. Results:­ Amiodarone caused relaxation in all grafts (ITA,RA, SV) between 10-9-10-3,5 M concentration in a dosedependent manner (p

Özet

Amaç: Bu çalışmada amiodaronun en çok kullanılangreftler olan internal torasik arter (İTA), safen ven (SV)ve radial arter (RA) üzerine etkisi organ banyosundaincelendi.Ça­lış­ma­pla­nı:­ Mayıs 2008 - Ekim 2008 tarihleriarasında izole koroner arter baypas greft (KABG)ameliyatı olan 20 hasta (16 erkek, 4 kadın; ort. yaş58.4±9.9 yıl; dağılım 38-80 yıl) çalışmaya dahil edildi.İnternal torasik arter, safen ven ve radial arterler top-landı. Örnekler +4 ºC Krebs solüsyonunda laboratuvarataşındı. Örnekler Krebs solüsyonu içeren 10 ml organbanyosunda askıya alındı.Bul gu lar: Amiodaron 10-9 -10-3,5 M konsantrasyon aralı-ğında tüm greftlerde (ITA, RA, SV) doz bağımlı gevşeme-ye yol açtı (p

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Cite This Article

GÜR, Ö., KARACA, O. G., KARADAĞ, Ç. H., CANBAZ, S., KALENDER, M., ECEVİT, A. N., EGE, T. (2022). Amiodaronun koroner arter baypas greftleri üzerine in vitro etkileri. Türk Göğüs Kalp Damar Cerrahisi Dergisi, Cilt: 23 - Sayı: 1, 14–18. https://ajindex.com/articles/624583

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References (15)

  1. Lytle BW, Loop FD, Cosgrove DM, Ratliff NB, Easley K, Taylor PC. Long-term (5 to 12 years) serial studies of internal mammary artery and saphenous vein coronary bypass grafts. J Thorac Cardiovasc Surg 1985;89:248-58
  2. Rosenfeldt FL, He GW, Buxton BF, Angus JA. Pharmacology of coronary artery bypass grafts. Ann Thorac Surg 1999;67:878-88
  3. Singh BN. Amiodarone: historical development and pharmacologic profile. Am Heart J 1983;106:788-97
  4. Zipes DP, Prystowsky EN, Heger JJ. Amiodarone: electrophysiologic actions, pharmacokinetics and clinical effects. J Am Coll Cardiol 1984;3:1059-71
  5. Mason JW. Amiodarone. N Engl J Med 1987;316:455-66
  6. Nattel S, Talajic M, Fermini B, Roy D. Amiodarone: pharmacology, clinical actions, and relationships between them. J Cardiovasc Electrophysiol 1992;3:266-80
  7. Kennedy RL, Griffiths H, Gray TA. Amiodarone and the thyroid. Clin Chem 1989;35:1882-7
  8. Singh BN, Venkatesh N, Nademanee K, Josephson MA, Kannan R. The historical development, cellular electrophysiology and pharmacology of amiodarone. Prog Cardiovasc Dis 1989;31:249-80
  9. Matsumori A, Ono K, Nishio R, Nose Y, Sasayama S. Amiodarone inhibits production of tumor necrosis factor- alpha by human mononuclear cells: a possible mechanism for its effect in heart failure. Circulation 1997;96:1386-9
  10. Perkerson KA, Gillespie EL, White CM, Kluger J, Takata H, Kardas M, et al. Impact of prophylactic amiodarone on length of hospital stay, stroke, and atrial fibrillation after cardiothoracic surgery. Pharmacotherapy 2005;25:320-4
  11. Ege T, Karaca OG, Gur O, Karadag H, Gurkan S, Duran E. The evaluation of in vitro effects of dipyridamole on coronary artery bypass grafts. Balkan Med J 2011;28:261-3
  12. Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Part 6: advanced cardiovascular life support: section 5: pharmacology I: agents for arrhythmias. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Circulation 2000;102:I112-28
  13. Ommen SR, Odell JA, Stanton MS. Atrial arrhythmias after cardiothoracic surgery. N Engl J Med 1997;336:1429-34
  14. Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med 2001;135:1061-73
  15. Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, et al. 2011 ACCF/AHA/HRS focused updates incorporated into the ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a r