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Journals / Klinik Psikofarmakoloji Bülteni / 2001 / Cilt: 11 - Sayı: 3

The investigation of free radical metabolism and antioxidant defense systems elements in patients with schizophrenic disorder

Şizofrenik bozukluğu olan hastalarda serbest radikal metabolizması ve nonenzimatik antioksidan savunma sistemi elemanlarının incelenmesi

Dilek DERİN
Şahap ERKOÇ
Ayla YAZICI
Pages
174–182
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

As a result, we can say that neurotoxic free radicals defects has an important role in schizophrenia physiopathology.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Object: We aimed to show changes in free radical metabolism and antioxidant defense systems elements in patients with schizophrenic disorder according to normal persons.
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Key Findings & Data:Method: There were 48 patients who were diagnosed as schizophrenia according to DSM-IV for 2 years.
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Conclusion & Impact:As a result, we can say that neurotoxic free radicals defects has an important role in schizophrenia physiopathology.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Object: We aimed to show changes in free radical metabolism and antioxidant defense systems elements in patients with schizophrenic disorder according to normal persons. Method: There were 48 patients who were diagnosed as schizophrenia according to DSM-IV for 2 years. We measured serum MDA(malondialdehyde), serum C and E vitamins and red blood cell GSH(glutathione) of patients and compared with 26 healthy persons. Results: Neurotoxic deformation caused by free radicals is shown by measuring lipid peroxidation's last product MDA level in the serum. These MDA levels were found higher where as serum vitamin C, serum vitamin E and red blood cell GSH level were found lower in patients with schizophrenic disorder. Conclusions: Differences between patients and normal persons according to these 4 parameters were found statistically significant. As a result, we can say that neurotoxic free radicals defects has an important role in schizophrenia physiopathology.

Özet

Şizofrenik bozukluğu olan hastalarda serbest radikal metabolizması ve nonenzimatik antioksidan savunma sistemi elemanlarının incelenmesi

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Cite This Article

DERİN, D., ERKOÇ, Ş., YAZICI, A. (2022). The investigation of free radical metabolism and antioxidant defense systems elements in patients with schizophrenic disorder. Klinik Psikofarmakoloji Bülteni, Cilt: 11 - Sayı: 3, 174–182. https://ajindex.com/articles/574528

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References (16)

  1. Buckman T D, Kling A S, Eiduson S, Sutphin MS, Steinberg A. Glutathion peroxidase and CT scan abnormalities in schizophrenia, Biol Psychiatry 1987; 28:1349-56
  2. Cadet J L. Free radical mechanisms in the central nervous system: an overview, Int J Neurosci 1988; 40:13-18
  3. Halliwel B. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. The Lancet 1984; 23: 1396-8
  4. McCreadie R G, MacDonald E, Wiles D, Campbell G, Paterson JR. The Nithsdale schizophrenia survey XIV. Plasma lipid peroxide and serum vitamin E level in patient with and without tardive diskinesia and in normal subject, Br J Psychiatry 1995; 167:610-17
  5. Pavlova O, Comparative studies of lipid peroxidations and antioxidant status in patients with schizophrenic, affective and schizoaffective psychosis, X. Dünya Psikiyatri Kongesi 1996 (tebliğ özeti)
  6. Reddy R, Sahebarao M, Mukherjee S, Enzymes of the antioxidants defence system in chronic schizophrenic patients, Biol Psychiatry 1991; 30:409-12
  7. Jesberger JA, Oxygen free radicals and brain function, Int J Neurosci 1991; 57:1-17
  8. Lohr BJ, Oxygen Radicals and Neuropsychiatric Illnesses, some speculations. Arch Gen Psychiatry 1991; 48:1097- 104
  9. Nasrallah HA (editor). Neurochemistry and neuropharmacology of schizophrenia. Amsterdam: Elsevier Science Publ., 1987
  10. Reddy R. Free radical pathology in schizophrenia. X. Dünya Psikiyatri Kongresi 1996:126. 11 Weber GF, The pathophysiology of reactive oxygen intermediates in the central nervous system. Med Hypothesis 1994; 43:223-30. 12 Southorn P, Garth P. Free radicals in the medicine. II. involvement in human disease. Mayo Clin Proc 1998; 63:390-408
  11. Delibaş N, Özcankaya R, Özgüner MF, Boz F. Bilişsel durum değişimleri, depresif ve psikotik belirtilerle serbest radikal aktivitesinin ilişkisi. Türk Psikiyatri Dergisi 1996; 7:46-52
  12. Lohr J, Cadet J L, Lohr M, Alpha tocopherol in tardive diskinesia (letter). The Lancet 198; 18:913-14. 15 Lohr J B, Cadet J L, Lohr M A. Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms, Schizoph Bull 1988; 14:291-6
  13. APA. Diagnostic and Statistical Manuel of Mental Disorders IV, Washington DC: American Psychatric Press, 1994
  14. Smith M, Sandy M, Di Monte D. Free radicals, lipid peroxidations and Parkinson’s disease (letter). The Lancet 1987; 3:38
  15. Andreasen CN. Schizophrenia; From Mind to Molecule, Washington DC: American Psychiatric Press, 1994
  16. Vaiva G, Tho