Journals / Klinik Psikofarmakoloji Bülteni / 2011 / Cilt: 21 - Sayı: 2

Propofol enjeksiyon ağrısında asetaminofen (turnikeli veya turnikesiz) ve lidokainın karşılaştırılması

Comparison of acetaminophen (with or without tourniquet) and lidocaine in propofol injection pain

Pages
100–104
Publication Date
2022-10-17
DOI
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Results: The groups were found to be different with regard to VRS scores (p

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Objective & Hypothesis:Background: We aimed to evaluate the effectiveness of i.v. acetaminophen (with or without tourniquet application) in comparison with that of lidocaine for the prevention of propofol-induced pain during induction of anaesthesia.
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Key Findings & Data:Methods: The patients’ arms were elevated for 20 s and a tourniquet was placed.
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Conclusion & Impact:Results: The groups were found to be different with regard to VRS scores (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: We aimed to evaluate the effectiveness of i.v. acetaminophen (with or without tourniquet application) in comparison with that of lidocaine for the prevention of propofol-induced pain during induction of anaesthesia. Methods: The patients’ arms were elevated for 20 s and a tourniquet was placed. In group 1, 10 ml saline; in group 2, 40 mg lidocaine in 10 ml saline; in group 3, 10 ml (100 mg) acetaminophen were administered; in group 4, the tourniquet was inflated to 100 mmHg, then 10 ml (100 mg) acetaminophen was given and after 2 min, the tourniquet was deflated. In all groups the duration of administration of the solutions were kept constant (10 s). Standard propofol solution (10 mg ml-1) was prepared at room temperature and propofol was given using an infusion pump by a person blinded to the study groups. All treatments were designed to deliver a 2mg/kg dose of propofol in a duration of 3 min. Pain during induction with propofol was scored using a 4-point verbal rating scale (none; 0, mild; 1, moderate; 2, and severe; 3) (VRS). Patients were asked to rate their pain at the injection site after infusion of ¼ of the solution, after ½ of the solution and, if hypnosis has not ensued, after ¾ of the solution. Results: The groups were found to be different with regard to VRS scores (p

Özet

Amaç: Anestezi indüksiyonu sırasında propofol kaynaklı ağrının önlenmesinde IV asetaminofen kullanımının (turnikeli veya turnikesiz) lidokain ile karşılaştırıldığındaki etkinliğini değerlendirmeyi amaçladık. Gereç ve Yöntem: Hastaların kolları 20 sn boyunca yukarıya kaldırıldıktan sonra turnike uygulandı. Grup 1’de 10 ml salin; grup 2’de 10 ml salin içinde 40 mg lidokain; grup 3’de 10 ml (100 mg) asetaminofen; grup 4’de turnike 100 mmHg’ya şişirildikten sonra 10 ml (100 mg) asetaminofen uygulandı ve 2 dk sonra turnike indirildi. Tüm gruplarda solüsyonların uygulanma hızı sabit tutuldu (10sn). Standart propofol solüsyonu (10 mg/ml), oda sıcaklığında hazırlandı ve çalışma gruplarını bilmeyen biri tarafından bir infüzyon pompası ile verildi. Tüm gruplar 3 dk içerisinde 2 mg/kg dozunda propofol alacak şekilde tasarlandı. Propofol indüksiyonu sırasında oluşan ağrı 4 puanlık verbal ağrı skalası (VAS) ile değerlendirildi (ağrı yok: 0, hafif: 1, orta: 2 ve çok: 3). Solüsyonun ¼’ ünün, ½’ sinin ve eğer hipnoz oluşmadı ise ¾’ ünün infüzyonunu takiben hastalardan enjeksiyon alanındaki ağrıyı değerlendirmeleri istendi. Bulgular: VAS skorlarına göre gruplar birbirinden farklı bulundu (p

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Cite This Article

ÖZKAN, S., SIZLAN, A., YANARATEŞ, Ö., DAĞLİ, G., MUTLU, M., ŞEN, H. (2022). Propofol enjeksiyon ağrısında asetaminofen (turnikeli veya turnikesiz) ve lidokainın karşılaştırılması. Klinik Psikofarmakoloji Bülteni, Cilt: 21 - Sayı: 2, 100–104. https://ajindex.com/articles/574148

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References (15)

  1. Klement W, Arndt JO. Pain on injection of propofol: effects of concentration and diluent. Br J Anaesth 1991; 67(3): 281-4
  2. Lyons B, Lohan D, Flynn C, McCarroll M. Modification of pain on injection of propofol. A comparison of pethidine and lignocaine. Anaesthesia 1996; 51(4): 394-5
  3. Tan CH, Onsiong MK. Pain on injection of propofol. Anaesthesia 1998; 53(5): 468-76
  4. Doenicke AW, Roizen MF, Rau J, O’Connor M, Kugler J, Klotz U, et al. Pharmacokinetics and pharmacodynamics of propofol in a new solvent. Anesth Analg 1997; 85(6): 1399-403
  5. Rau J, Roizen MF, Doenicke AW, O’Connor MF, Strohschneider U. Propofol in an emulsion of long- and medium-chain triglycerides: the effect on pain. Anesth Analg 2001; 93(2): 382-4
  6. McCrirrick A, Hunter S. Pain on injection of propofol: The effect of injectate temperature. Anaesthesia 1990; 45(6): 443-4
  7. Stokes DN, Robson N, Hunton P. Effect of diluting propofol on the incidence of pain on injection and venous sequelae. Br J Anaesth 1989; 62(2): 202-3
  8. Sen H, Yanarates O, Sizlan A, Mutlu M, Özkan S, Dağlı G. Effect of saline dilution on propofol injection pain: comparison with lidocaine. Turkiye Klinikleri J Med Sci 2009; 29(1): 150-4
  9. Picard P, Tramer MR. Prevention of pain on injection with propofol: A quantitative systematic review. Anesth Analg 2000; 90(4): 963-9
  10. Uğur B, Erpek G, Aydın ON. Subanestezik dozdaki ketaminin, propofolün oluşturduğu ağrıya ve hemodinamik değişikliklere etkisi. Turkiye Klinikleri J Anest Reanim 2005; 3(2): 59-65
  11. Agarwal A, Ansari MF, Gupta D, Pandey R, Raza M,Singh PK, et al. Pretreatment with thiopental for prevention of pain associated with propofol injection. Anesth Analg 2004; 98(3): 683-6
  12. Aouad MT, Siddik-Sayyid SM, Al-Alami AA, Baraka AS. Multimodal analgesia to prevent propofol-induced pain: pretreatment with remifentanil and lidocaine versus remifentanil or lidocaine alone. Anesth Analg 2007; 104(6): 1540-4
  13. Beh T, Splinter W, Kim J. In children, nitrous oxide decreases pain on injection of propofol mixed with lidocaine. Can J Anesth 2002; 49(10): 1061-3
  14. Fujii Y, Itakura M. Comparison of lidocaine, metoclopramide, and flurbiprofen axetil for reducing pain on injection of propofol in Japanese adult surgical patients: A prospective, randomized, double-blind, parallel-group, placebo-controlled study. Clinical Therapeutics 2008; 30(2): 280-6
  15. Fujii Y. Pretreatment with flurbiprofen axetil and venous occlusion to reduce pain during injectio