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Journals / Klinik Psikofarmakoloji Bülteni / 2013 / Cilt: 23 - Sayı: 4

Bipolar bozukluk ve alkol-madde kullanım bozuklukları eştanısında farmakolojik tedavi seçenekleri

Pharmacotherapy options in comorbid bipolar disorder and alcohol-substance use disorders

Kursat ALTINBAS
Cuneyt EVREN
Pages
378–389
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Future prospective studies are required for improvement of treatments in comorbid bipolar and alcohol-substance use disorders.

📌 3 Key Takeaways

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Objective & Hypothesis:Epidemiological studies have reported that alcohol- substance use disorders are the most common co-occuring axis I disorder among patients with bipolar disorders.
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Key Findings & Data:However, the prospective links observed between bipolar disorders and alcohol-substance use disorders support clinical interventions that incorporate both disorders in developing treatment strategies.
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Conclusion & Impact:Future prospective studies are required for improvement of treatments in comorbid bipolar and alcohol-substance use disorders.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Epidemiological studies have reported that alcohol- substance use disorders are the most common co-occuring axis I disorder among patients with bipolar disorders. Comorbidity of alcohol-substance use disorders mostly worsens the course of illness in bipolar patients and underlying mechanisms of the association between both disorders still remain unclear. However, the prospective links observed between bipolar disorders and alcohol-substance use disorders support clinical interventions that incorporate both disorders in developing treatment strategies. Here we review the pharmacological treatment choices for alcohol-substance use disorders accompanying bipolar disorders, despite a limited number of treatment studies. The first-line (evidence-based) and second- line (expert opinion) pharmacological agents of bipolar disorder with comorbid alcohol-substance use disorders are quetiapine, lithium or valproate for the depressive phase; valproate or quetiapine for the manic/mixed phase, and valproate monotherapy or a combination of valproate with naltrexone or disulfiram for maintenance. Future prospective studies are required for improvement of treatments in comorbid bipolar and alcohol-substance use disorders.

Özet

Epidemiyolojik çalışmalar, bipolar bozuklukta en sıkeşlik eden Eksen I psikiyatrik hastalığın alkol-maddekullanım bozuklukları olduğunu bildirmektedir. Eşlikeden alkol-madde kullanım bozuklukları bipolar bozukluk seyrini kötüleştirmekle birlikte bu iki hastalık arasındaki ilişkinin altında yatan mekanizma halenaçıklığa kavuşmamıştır. Yine de, bipolar bozukluk vealkol-madde kullanım bozuklukları arasında gözlenenmuhtemel ilişki, her iki hastalık grubunu kapsayan tedavi stratejileri geliştirilmesini sağlayan klinik uygulamaları desteklemektedir. Biz de bu derlemede, kısıtlı sayıdaki çalışmalara rağmen, bipolar bozukluğa eşlik edenalkol-madde kullanım bozukluklarının farmakolojik tedavisini gözden geçirmekteyiz. Alkol-madde kullanım bozukluğu eştanılı bipolar bozukluk her bir hastalık dönemi için tedavi seçenekleri kanıta dayalı birinci sırave uzman görüşü ikinci sıra olarak depresif dönem içinketiapin, lityum ve valproat; manik/karma dönem için valproat ve ketiapin; idame dönemi için ise valproatmonoterapisi veya naltrekson/dilsülfiram şeklinde gruplandırılmıştır. Bipolar bozukluğa eşlik eden alkol-madde kullanım bozukluğu tedavisini geliştirmeyedönük uzunlamasına izlem çalışmalarına ihtiyaç vardır.

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Cite This Article

ALTINBAS, K., EVREN, C. (2022). Bipolar bozukluk ve alkol-madde kullanım bozuklukları eştanısında farmakolojik tedavi seçenekleri. Klinik Psikofarmakoloji Bülteni, Cilt: 23 - Sayı: 4, 378–389. https://ajindex.com/articles/574056

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