A case of DRESS syndrome mimicking sepsis

Objective & Hypothesis:Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, characterized by fever, skin rash, lymph node enlargement, and internal organ involvement.

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Key Findings & Data:This case demonstrates that procalcitonin may be increased in patients with DRESS syndrome.

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Conclusion & Impact:This is the first report of opipramol-induced DRESS syndrome associated with high procalcitonin.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, characterized by fever, skin rash, lymph node enlargement, and internal organ involvement. We present a patient with a high serum procalcitonin level and a clinical picture mimicking sepsis, thereafter diagnosed as DRESS syndrome. This case demonstrates that procalcitonin may be increased in patients with DRESS syndrome. This is the first report of opipramol-induced DRESS syndrome associated with high procalcitonin.

Özet

Drug Rash with Eosinophilia and Systemic Symptoms(DRESS) sendromu ateş, deri döküntüleri, lenfadenomegali ve iç organ tutulumuyla karakterize olan ciddi bir ilaca aşırı duyarlılık reaksiyonudur. Bu yazıda prokalsitonin yüksekliği olan ve sepsisi taklit eden ancak takibinde opipramole bağlı DRESS sendromu olduğu ortaya çıkan bir olgu sunulmuştur. Bu olgu prokalsitoninin DRESS sendromlu hastalarda da artabileceğini ve DRESS sendromlu vakaların sepsisi taklit edebileceğini göstermektedir. Ayrıca opipramole bağlı gösterilmiş olan ilk DRESS olgusudur.

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Cite This Article

KOÇAK, Z. T., UÇAL, S. B., BULUT, C., BOYRAZ, S., VAHABOĞLU, G. (2022). A case of DRESS syndrome mimicking sepsis. Klimik Dergisi, Cilt: 24 - Sayı: 2, 132–134. https://ajindex.com/articles/573701

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References (1)

Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med Surg. 1996; 15(4): 250-7. [Crossref] 2. Peyrière H, Dereure O, Breton H, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol. 2006; 155(2): 422-8. [Crossref] 3. Lerch M, Pichler WJ. The immunological and clinical spectrum of delayed drug-induced exanthems. Curr Opin Allergy Clin Immunol. 2004; 4(5): 411-9. [Crossref] 4. Shiohara T, Inaoka M, Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses. Allergol Int. 2006; 55(1): 1-8. [Crossref] 5. Kano Y, Inaoka M, Shiohara T. Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia. Arch Dermatol. 2004; 140(2): 183-8. [Crossref] 6. Yücel A, Karakuş G, Günaştı S. Psikotrop ilaçların dermatolojik yan etkileri ve tedavi yaklaşımları. Klinik Psikofarmakoloji Bülteni. 2008; 18: 235-44. 7. Morimoto T, Sato T, Matsuoka A, et al. Trimethoprim-sulfamethoxazole- induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6. Intern Med. 2006; 45(2): 101-5. [Crossref] 8. Bonaci-Nikolic B, Jeremic I, Nikolic M, Andrejevic S, Lavadinovic L. High procalcitonin in a patient with drug hypersensitivity syndrome. Intern Med. 2009; 48(16): 1471-4. [Crossref] 9. Schneider HG, Lam QT. Procalcitonin for the clinical laboratory: a review. Pathology. 2007; 39(4): 383-90. [Crossref] 10. Müller B, Becker KL. Procalcitonin: how a hormone became a marker and mediator of sepsis. Swiss Med Wkly. 2001; 131(41-42): 595-602. 11. Delèvaux I, André M, Colombier M, et al. Can procalcitonin measurement help in differentiating between bacterial infection and other kinds of inflammatory processes? Ann Rheum Dis. 2003; 62(4): 337-40. [Crossref]