Journals / Klimik Dergisi / 2015 / Cilt: 28 - Sayı: 1

A Case of Renal Aspergillosis Mimicking Renal Cell Cancer

Renal Hücreli Kanseri Taklit Eden Renal Aspergilloz Olgusu

Pages
42–44
Publication Date
2022-10-18
DOI
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Klimik Dergisi 2015; 28(1): 42-4

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Objective & Hypothesis:We report a 56-year-old male patient with diabetes mellitus type 2 for 15 years who referred to our hospital with a history of leftside pain for 2 months, 10 kilograms of weight loss in the last 3 months and intermittent fever attacks over 38°C for 4 weeks.
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Key Findings & Data:C-reactive protein (CRP) was high as 158 mg/L but no microorganism was identified in urinary and blood cultures.
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Conclusion & Impact:Klimik Dergisi 2015; 28(1): 42-4
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

We report a 56-year-old male patient with diabetes mellitus type 2 for 15 years who referred to our hospital with a history of leftside pain for 2 months, 10 kilograms of weight loss in the last 3 months and intermittent fever attacks over 38°C for 4 weeks. The results of laboratory tests including complete blood count, kidney and liver functions, and blood electrolytes turned out to be normal. C-reactive protein (CRP) was high as 158 mg/L but no microorganism was identified in urinary and blood cultures. In abdominopelvic computerized tomography (CT), a cystic lesion was observed at the left kidney. The result of indirect hemagglutination test for hydatid cyst was negative. Because of the risk of malignancy, left radical nephrectomy with subcostal chevron incision was performed. During the operation, a lesion on the anterior part of the kidney filled with purulent fluid was observed and drained. Histopathological examination revealed a kind of xanthogranulomatous pyelonephritis and microscopic examination with hematoxylin and eosin displayed branching septate hyphae. Galactomannan antigen was detected in necrotic material with latex agglutination test and Aspergillus fumigatus was isolated in the culture. Thoracal and cranial CTs, echocardiography and ophthalmic examination were normal. An oral therapy of 100 mg itraconazole 2 times a day for 6 weeks was given. Post-therapy CRP was normal and no lesion was identified at the control CT. As a result, fungal infections, especially aspergillosis should be kept in mind in immunodeficient patients or patients with comorbidities like diabetes mellitus with a renal mass. Klimik Dergisi 2015; 28(1): 42-4

Özet

On beş yıldır tip 2 diabetes mellitus öyküsü olan 56 yaşındaki erkek, son 2 aydır devam eden sol yan ağrısı, son 3 ayda 10 kilo kadar kilo kaybı ve 1 aydır zaman zaman 38°C'yi geçen ateş ataklarıyla başvurdu. Hastanın tam kan sayımı ve biyokimyasal testleri normal olarak saptanırken C-reaktif protein (CRP) değeri 158 mg/lt olarak izlendi. İdrar ve kan kültürlerinde mikroorganizma saptanmadı. Abdominopelvik bilgisayarlı tomografide (BT) sol böbrekte kistik bir kitle tespit edildi. Kist hidatik yönünden indirekt hemaglütinasyon testi negatif bulundu. Böbrekteki lezyon, olası malignite riski nedeniyle subkostal "chevron" kesiyle sol radikal nefrektomi yapılarak eksize edildi. İntraoperatif olarak böbreğin anterior kısmındaki tümör olduğu düşünülen lezyon içerisinden pürülan sıvı drene oldu. Böbrek dokusunda histopatolojik olarak ksantogranülomatöz pyelonefritle birlikte hematoksilen eozin boyamasında dallanma gösteren ve septumları olan hifler izlendi. Nekrotik materyalde lateks aglütinasyon yöntemiyle galaktomannan antijeni saptandı. Kültürde Aspergillus fumigatus üremesi üzerine renal aspergilloz tanısı kesinleştirildi. Tarama amacıyla çekilen toraks ve kraniyal BT'de, ekokardiyografide ve yapılan oftalmoskopik değerlendirmede başka lezyon saptanmadı. Hastaya 6 hafta süreyle 2x100 mg oral itrakonazol tedavisi başlandı. Tedavi sonunda CRP normal olarak saptanırken, kontrol BT'de patolojik bulguya rastlanmadı. Sonuç olarak immün yetmezliği olan veya diabetes mellitus gibi komorbiditeleri olan hastalarda renal kitle saptandığında fungal infeksiyonlar ve özellikle de aspergilloz akla gelmelidir. Klimik Dergisi 2015; 28(1): 42-4

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Cite This Article

GÖKÇE, İ., SÜER, E., GÜLPINAR, Ö., ÖZCAN, C., ÖZKIDIK, M., YILMAZ, G. (2022). A Case of Renal Aspergillosis Mimicking Renal Cell Cancer. Klimik Dergisi, Cilt: 28 - Sayı: 1, 42–44. https://ajindex.com/articles/573624

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