AI Summary & Key Takeaways
AI InsightWe present here a 27-year-old patient in whom AGEP developed 3 times after the same treatment while receiving a combination of isoniazid, rifampin, ethambutol and pyrazinamide for tuberculous meningitis, in whom the causative drug was found to be pyrazinamide.
📌 3 Key Takeaways
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption characterized by generalized non-follicular sterile pustules. The most frequent causes are antibiotics, sulphonamides, and antipyretic analgesics. It is rarely reported to occur due to antituberculous medications. We present here a 27-year-old patient in whom AGEP developed 3 times after the same treatment while receiving a combination of isoniazid, rifampin, ethambutol and pyrazinamide for tuberculous meningitis, in whom the causative drug was found to be pyrazinamide.
Özet
Akut jeneralize ekzantematöz püstüloz (AGEP), yaygın, foliküler olmayan steril püstüllerle karakterize nadir bir kutanöz döküntüdür. Antibiyotikler, sülfonamidler, ateş düşürücü ve ağrı kesiciler bu ilaç döküntüsünün en sık nedenleridir. Nadir de olsa antitüberküloz ilaçlara karşı da oluştuğu bildirilmiştir. Bu bildiride tüberkülöz menenjit nedeniyle kombine izoniazid, rifampisin, etambutol ve pirazinamid kullanırken AGEP gelişen ve daha sonra sorumlu ilacın pirazinamid olduğu bulunan 27 yaşında bir hastayı sunduk.