SavedAdd your journal

Journals / KBB-Forum / 2022 / Cilt: 21 - Sayı: 2

PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY

RADYOTERAPİ İLE TEDAVİ EDİLEN ERKEN EVRE GLOTTİK LARİNGEAL SKUAMÖZ HÜCRELİ KARSİNOMDA HİPOKSİ İLE İNDÜKLENEBİLİR FAKTÖR 1-ALFA VE NÜKLEER FAKTÖR KAPPA B'NIN PROGNOSTİK ÖNEMİ

Mehmet Özgür PINARBAŞLI
Mehmet Akif ABAKAY
Melek Kezban GÜRBÜZ
Mustafa Fuat AÇIKALIN
Durmuş ETİZ
Journal
KBB-Forum
Pages
57–63
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The relationship between overall survival and investigated parameters was analyzed by Kaplan-Meier and regression analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Early-stage glottic laryngeal squamous cell carcinoma has good mortality and morbidity rates with radiotherapy.
📊
Key Findings & Data:However, recurrent cases are at risk of increased morbidity and mortality.
💡
Conclusion & Impact:The relationship between overall survival and investigated parameters was analyzed by Kaplan-Meier and regression analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Early-stage glottic laryngeal squamous cell carcinoma has good mortality and morbidity rates with radiotherapy. However, recurrent cases are at risk of increased morbidity and mortality. Therefore, the identification of new prognostic markers is needed. Material and Methods: Forty patients with early-stage glottic carcinoma managed with radiotherapy were included in this study. Immunohistochemical evaluation was performed for Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha from biopsy specimens. The relationship between overall survival and investigated parameters was analyzed by Kaplan-Meier and regression analysis. Results: There were 11 recurrences and 20 deaths occurred during the follow-up period. There was no significant relationship between Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining and overall survival. There were no significant correlations between age, smoking status, differentiation, T stage, and anterior commissure involvement with Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha staining. Conclusion: It seems pretreatment Nuclear factor-kappa B and Hypoxia-inducible factor 1-alpha expression levels do not correlate with overall survival in early-stage glottic carcinoma primarily managed with radiotherapy.

Özet

Giriş: Erken evre glottik laringeal skuamöz hücreli karsinom, radyoterapi ile iyi mortalite ve morbidite oranlarına sahiptir. Bununla birlikte, nüks vakalar artmış morbidite ve mortalite riski altındadır. Bu nedenle yeni prognostik belirteçlerin tanımlanmasına ihtiyaç duyulmuştur. Amaç ve Yöntemler: Bu çalışmaya radyoterapi ile tedavi edilen erken evre glottik karsinomlu kırk hasta dahil edildi. Biyopsi örneklerinden Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa için immünohistokimyasal değerlendirme yapıldı. Genel sağkalım ile araştırılan parametreler arasındaki ilişki Kaplan-Meier ve regresyon analizleri ile analiz edildi. Bulgular: Takip süresince 11 nüks ve 20 ölüm meydana geldi. Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa boyama ve genel sağkalım arasında anlamlı bir ilişki yoktu. Yaş, sigara içme durumu, farklılaşma, T evresi ve ön komissür tutulumu ile Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa boyama arasında anlamlı bir ilişki yoktu. Tartışma ve Sonuçlar: Primer olarak radyoterapi ile tedavi edilen erken evre glottik karsinomda tedavi öncesi Nükleer faktör-kappa B ve Hipoksi ile indüklenebilir faktör 1-alfa ekspresyon düzeylerinin genel sağkalım ile ilişkili olmadığı saptanmıştır.

🔖

Cite This Article

PINARBAŞLI, M. Ö., ABAKAY, M. A., GÜRBÜZ, M. K., AÇIKALIN, M. F., ETİZ, D. (2022). PROGNOSTIC IMPORTANCE OF HYPOXIA-INDUCIBLE FACTOR 1-ALPHA AND NUCLEAR FACTOR KAPPA B IN EARLY-STAGE GLOTTIC LARYNGEAL SQUAMOUS CELL CARCINOMA TREATED WITH RADIOTHERAPY. KBB-Forum, Cilt: 21 - Sayı: 2, 57–63. https://ajindex.com/articles/573046

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther. 2020 Sep 21;5(1):209. https://doi.org/10.1038/s41392-020-00312-6. PMCID: PMC7506548
  2. Kordbacheh F, Farah CS. Molecular Pathways and Druggable Targets in Head and Neck Squamous Cell Carcinoma. Cancers. 2021;13(14):3453.
  3. Alsahafi E, Begg K, Amelio I et al. Clinical update on head and neck cancer: molecular biology and ongoing challenges. Cell Death Dis. 2019 Jul 15;10(8):540. doi: 10.1038/s41419-019-1769-9.; PMCID: PMC6629629
  4. D'Ignazio L, Rocha S. Hypoxia Induced NF-κB. Cells. 2016;5(1):10.
  5. Yoshida K, Sasaki R, Nishimura H et al. Nuclear factor-kappaB expression as a novel marker of radioresistance in early-stage laryngeal cancer. Head Neck. 2010;32(5):646-655.
  6. Monisha J, Roy NK, Bordoloi D et al. Nuclear Factor Kappa B: A Potential Target to Persecute Head and Neck Cancer. Curr Drug Targets. 2017;18(2):232-253. https://doi.org/ 10.2174/1389450117666160201112330
  7. Simo R, Bradley P, Chevalier D et al. European Laryngological Society. ELS Recommendations for the follow-up of patients treated for laryngeal cancer. Eur Arch Otorhinolaryngol 2014;271(9):2469-79
  8. Kwon OJ, Park JJ, Ko GH et al. HIF-1α and CA-IX as predictors of locoregional control for determining the optimal treatment modality for early-stage laryngeal carcinoma. Head Neck. 2015;37(4):505-10.
  9. Wilczynski J, Duechler M, Czyz M. Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I. Arch Immunol Ther Exp (Warsz). 2011;59(4):289-299.
  10. Li F, Sethi G. Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy. Biochim Biophys Acta. 2010;1805(2):167-180.
  11. Balermpas P, Michel Y, Wagenblast J et al. Nuclear NF-κB expression correlates with outcome among patients with head and neck squamous cell carcinoma treated with primary chemoradiation therapy. Int J Radiat Oncol Biol Phys. 2013;86(4):785-790.
  12. Wachters JE, Schrijvers ML, Slagter-Menkema L et al. Prognostic significance of HIF-1α, CA-IX, and OPN in T1-T2 laryngeal carcinoma treated with radiotherapy. Laryngoscope. 2013