Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2018 / Cilt: 24 - Sayı: 6

Preliminary Study on Association of EDNRB Gene with Heterochromia Iridis in Cats (Felis catus)

Kedilerde (Felis catus) EDNRB Geni ile Heterokromia İridis Arasında İlişkiye Dair Ön Çalışma

Pages
853–858
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was no statistical association between the variations near the three exons of EDNRB and felineheterochromia iridis (chi-square test, P-value >0.05).

📌 3 Key Takeaways

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Objective & Hypothesis:This study conducted an investigation on three exons of the endothelin receptor type B (EDNRB) gene of Thai odd-eyed cats to find outthe association between the variations in the gene and heterochromia iridis.
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Key Findings & Data:DNA sequencing analysis was performed on 11 odd-eyedcats compared to 11 normal-eyed cats.
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Conclusion & Impact:There was no statistical association between the variations near the three exons of EDNRB and felineheterochromia iridis (chi-square test, P-value >0.05).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study conducted an investigation on three exons of the endothelin receptor type B (EDNRB) gene of Thai odd-eyed cats to find outthe association between the variations in the gene and heterochromia iridis. DNA sequencing analysis was performed on 11 odd-eyedcats compared to 11 normal-eyed cats. Seven variations were found across the studied region (XM_003980457.2: c.610A>G, c.820+40C>T,c.821-14C>T, c.916A>G, c.1025+36G>T, c.1025+69A>T, and c.1025+138C>T) with two of them (c.610A>G and c.916A>G) causing amino acidchanges (P.Asn128Ser and P.Val230Ala). There was no statistical association between the variations near the three exons of EDNRB and felineheterochromia iridis (chi-square test, P-value >0.05).

Özet

Bu çalışmada Tayland tek-göz kedilerinde endotelin reseptör tip B (EDNRB) geninin üç ekzonunda gen varyasyonu ile heterokromia iridis arasında bir ilişki olup olmadığı araştırıldı. On bir tek-göz kedide DNA sekans analizi yapıldı ve 11 normal gözlü kedi ile karşılaştırıldı. Çalışılan bölge itibarıyla yedi varyasyon (XM_003980457.2: c.610A>G, c.820+40C>T, c.821-14C>T, c.916A>G, c.1025+36G>T, c.1025+69A>T ve c.1025+138C>T) tespit edildi ve bunların ikisi (c.610A>G ve c.916A>G) amino asit değişimine (P.Asn128Ser ve P.Val230Ala) neden olmaktaydı. Çalışmada, üç EDNRB ekzonu yakınındaki varyasyonlar ile kedi heterokromia iridis arasında istatistiksel bir ilişki tespit edilmedi (ki kare testi, P-değeri >0.05).

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Cite This Article

NGANVONGPANIT, K., CHOMDEJ, S., BUDDHACHAT, K., SIENGDEE, P., LEELAWATTANAKUL, P., PHONGROOP, K., PRADİT, W. (2022). Preliminary Study on Association of EDNRB Gene with Heterochromia Iridis in Cats (Felis catus). Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 24 - Sayı: 6, 853–858. https://ajindex.com/articles/569914

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