Journals / Kadın Doğum Dergisi / 2004 / Cilt: 2 - Sayı: 4

Erythrocyte zinc levels and the thyroid functions in patients with hyperemesis gravidarum

Hiperemezis gravidarumda tiroid fonksiyonları ve eritrosit içi çinko düzeyleri

Pages
284–286
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

But erythrocyte zinc levels may help to distinguish between transient hypertroidism and preexisting thyrotoxicosis which may exacerbate in pregnancy and cause serious problems.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate the incidence and degree of thyroidal stimulation in patients with hyperemesis, and the correlation between thyroid function, the erythrocyte zinc level and the severity of the hyperemesis gravidarum.
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Key Findings & Data:Methods: The sera of 26 patients presenting with hyperemesis gravidarum and 21 othervise healthy pregnant women in first trimester were collected and TSH, TT3, TT4, FT3, FT4 and erythrocyte zinc concentartions determined.
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Conclusion & Impact:But erythrocyte zinc levels may help to distinguish between transient hypertroidism and preexisting thyrotoxicosis which may exacerbate in pregnancy and cause serious problems.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate the incidence and degree of thyroidal stimulation in patients with hyperemesis, and the correlation between thyroid function, the erythrocyte zinc level and the severity of the hyperemesis gravidarum. Methods: The sera of 26 patients presenting with hyperemesis gravidarum and 21 othervise healthy pregnant women in first trimester were collected and TSH, TT3, TT4, FT3, FT4 and erythrocyte zinc concentartions determined. The severity of the hyperemesis gravidarum was evaluated by the degree of ketonuria, more than % 5 weight loss, and dehydration. An ultrasound to confirm the gestational age and to exclude a multiple pregnancy or a trophoblastic disease was performed. . Statistycal analyses carried out with student's t-test. Results: The age of the mother, the parity and the gestational age at admission were are comparable in both groups, and there was no difference between both groups. TT3 levels were significantly higher in hyperemesis patients (p 0,05). Erythrocyte zinc levels did not differ between hyperemesis and control groups (p > 0,05). Conclusion: The thyroid dysfunction in hyperemesis gravidarum seems to be transient in nature and requires no treatment. But erythrocyte zinc levels may help to distinguish between transient hypertroidism and preexisting thyrotoxicosis which may exacerbate in pregnancy and cause serious problems.

Özet

Amaç: Hiperemezis gravidarum tablosu ile başvuran hastalarda troid hormon seviyelerini ve bu hormon seviyelerinin eritrosit içi çinko düzeyi ile olan ilişkisini belirlemek ve troid hormonu seviyesindeki değişikliklerin gebeliğe bağlı olup olmadığını araştırmak amacıyla yapılmıştır. Materyal ve Metod: Prospektif olarak gerçekleştirilen bu çalışmada ilk trimesterde bulunan ve hiperemezis gravidarum tanısı konan 26 gebe ile yine ilk trimesterde olan ve şikayeti olmayan 21 adet sağlıklı gebenin serum TSH, TT3, TT4, FT3, FT4 ve eritrosit içi çinko ölçümleri yapılarak karşılaştırıldı. Hiperemezis gravidarum tanısı için erken gebelikte dehidratasyon, ketonüri ve % 5 ten fazla kilo kaybı kriterleri alındı. Gestasyonel yaşı konfirme etmek ve trofoblastik hastalıklar ile çoğul gebeliği ekarte etmek için ultrasonografik inceleme yapıldı. İstatistiksel analizler student's t-testi kullanılarak gerçekleştirildi. Bulgular : Her iki grupta yaş, gebelik haftası ve parite açısından istatistiksel farklılık yoktu. TT3 değeri hiperemezis grubunda istatistiksel olarak anlamlı bir artış gösterdi (p 0,05). Eritrosit içi çinko değerleri her iki grupta da istatistiksel olarak farklı değildi (p >0,05). Sonuç: Hiperemezis gravidarum hastalarındagözlenen tiroid disfonksiyonu geçici özelliktedir ancak daha önce var olan ve gebelikte alevlenerek ciddi sonuçlara yol açabilecek bir tirotoksikozu belirleyebilmek için, tiroid fonksiyonlarında artış gözlenen hiperemezis hastalarındaeritrosit içi çinko düzeyini belirlemek faydalı olabilir.

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Cite This Article

TURAN, C., ÇAM, M., ÇAM, Ç., KARATEKE, A. (2022). Erythrocyte zinc levels and the thyroid functions in patients with hyperemesis gravidarum. Kadın Doğum Dergisi, Cilt: 2 - Sayı: 4, 284–286. https://ajindex.com/articles/569134

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References (5)

  1. Transient hyperthyroidism of hyperemesis gravidarum: a sheep in wolfs clothing.Caffrey TJ. J Am Board Fam Pract. 2000 Jan-Feb;13(l):35-8
  2. Chin RK, Lao T, Kong A. Hyperemezis gravidarum in Chinese women. Asia Oceania J Obstet Gynecol, 1987, 13:261-4 3- Dozeman R, Kaiser F, Cass O, Pries J. Hypertroidism appearing as hyperemesis gravidarum. Arch Intern Med 1983,143:2203-4 4- Jeffcoate WJ, Bain C, Recurrent pregnancy induced thyrotoxicoss presenting as hyperemesis gravidarum. Br J Obstet Gynaecol 1985,92:413-5 5- Valentine BH, Jones C, Tyack AJ. Hyperemesiz gravidarum due to thyrotoxicosis. 1980,Postgrad Med J1980,56;746-7 6- Hyperemesis in the first trimester of pregnancy: role of biological hyperthyroidism and fetal sex. Deruelle P, Dufour P, Subtil D, Houfüin-Debarge V, Dherbomez A, Wemeau JL, Puech Gynecol Obstet Fertil. 2002 Mar;30(3):204-9 7- Bruun TH, Kristoffersen K. Thyroid function during pregnancy with special reference to hydatiform mole and hyperemesis. Acta Endocrinol 1978, 88;383-9 8- O'Moore RR, McSweeney J, Thornton CA, Lillie EW. Biochemical changes in hyperemesis gravidarum. Ann Clin Biochem 1979, 16;Suppl 63 9- Ylikorkala O, Kaupilla A, Happalahti J. Follicle stimulating hormone, thyrotrophin, human growth hormone and prolactin in hyperemesis gravidarum. Am J Obstet Gynecol 1976,83;528-33 10- Juras N, Banovac K, Sekso M. Increased serum reverse triiodothyronine in patients with hyperemesis gravidarum. Acta Endocrinol 1983,102;284-7 11- Chin RK, Lao TT, Swaminathan R, Mak YT. A longitudinal study of changes in erythrocyte zinc concentration in hyperemesis gravidarum.Gynecol Obstet Invest,1990;29 (l):22-5
  3. Lao TT, Chin RK, Mak YT, Panesar NS. Plasma zinc concentration and thyroid function in hyperemetic pregnancies.Acta Obstet Gynecol Scand. 1988;67(7):599-604 13-Fairweather DVI. Nausea and vomiting in pregnancy. Am J Obstet Gynecol 1988,102;135 14- Transient hyperthyroidism of hyperemesis gravidarum: a sheep in wolfs clothing.Caffrey TJ. J Am Board Fam Pract. 2000 Jan Feb;13(l):35-8
  4. Human chorionic gonadotropin and the thyroid: hyperemesis gravidarum and trophoblastic tumors. Hershman JM.Thyroid. 1999 Jul;9(7):653-7
  5. Yoshamura M, Nishikawa M, Yoshikawa N, Horimoto M, inada M. Mechanism of thyroid stimulation by human chorionic gonadotrophin in sera of normal pregnant women. Acta Endocrinologica 1991,124;173-8 17-Aihara K, Nishi Y, Hatano S, Kihara M, Yoshimitsu K, Takeichi N, Ito T, Ezaki H, Usui T. Zinc, copper, manganes