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Journals / Journal of the Turkish-German Gynecological Association / 2018 / Cilt: 19 - Sayı: 2

Does progesterone have protective effects on ovarian ischemia-reperfusion injury?

Ertan ADALI
Emine ÖZTÜRK
Banu GÜLEÇ BAŞER
Mine İslimye TAŞKIN
Adnan Adil HISMIOĞULLARI
Arzu YAY
Pages
87–93
Publication Date
2022-10-18
DOI
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Tissue TAS levels were higher in group 3 than in group 2 (p

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Objective & Hypothesis:Objective: The aim of the present study was to evaluate the effects of progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through the evaluation of biochemical and histopathologic parameters.Material and Methods: Twenty-one female Wistar albino rats were divided into three groups.
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Key Findings & Data:Group 1: Sham; group 2: I/R; group 3: I/R+PG (8 mg/kg).
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Conclusion & Impact:Tissue TAS levels were higher in group 3 than in group 2 (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the present study was to evaluate the effects of progesterone (PG) against ovarian ischemia-reperfusion (I/R) injury through the evaluation of biochemical and histopathologic parameters.Material and Methods: Twenty-one female Wistar albino rats were divided into three groups. Group 1: Sham; group 2: I/R; group 3: I/R+PG (8 mg/kg). PG was administered intraperitoneally to the rats in group 3, 30 minutes before a detorsion operation. Ovarian I/R injury was evaluated in serum and tissue by using biochemical parameters including malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index, neutrophil gelatinase-associated lipocalin (NGAL) and immunofluorescence staining by using a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay.Results: Serum and tissue TOS levels were significantly lower in group 3 than in group 2. Tissue TAS levels were higher in group 3 than in group 2 (p

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Cite This Article

ADALI, E., ÖZTÜRK, E., BAŞER, B. G., TAŞKIN, M. İ., HISMIOĞULLARI, A. A., YAY, A. (2022). Does progesterone have protective effects on ovarian ischemia-reperfusion injury?. Journal of the Turkish-German Gynecological Association, Cilt: 19 - Sayı: 2, 87–93. https://ajindex.com/articles/568064

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