Gebelerde serum adenozin deaminaz ve izoenzim aktivitesi

Objective & Hypothesis:Objective: ADA is widely distributed in human tissues, which may contribute to the maturation of the immunological system, especially the proliferation and differentiation of lymphoid cells, and seems to be critical at different stages of the maturation process.

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Key Findings & Data:In this study we examined changes in serum total ADA activity and the patterns of two ADA isoenzymes, ADA-1 and ADA-2, in healthy pregnant women, and evaluated the possible role of the alteration of cell-mediated immunity during pregnancy as causes of changes in ADA activity.

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Conclusion & Impact:Results: Serum ADA, ADA-1 and ADA-2 activities in healthy pregnant women were significantly lower than in nonpregnant women (p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Objective: ADA is widely distributed in human tissues, which may contribute to the maturation of the immunological system, especially the proliferation and differentiation of lymphoid cells, and seems to be critical at different stages of the maturation process. The activity of ADA changes in diseases characterized by the alteration of cell-mediated immunity. In this study we examined changes in serum total ADA activity and the patterns of two ADA isoenzymes, ADA-1 and ADA-2, in healthy pregnant women, and evaluated the possible role of the alteration of cell-mediated immunity during pregnancy as causes of changes in ADA activity. Materials and Methods: We measured serum activities of total ADA, ADA-1 and ADA-2 in healthy pregnant women (n=129) and age-matched healthy nonpregnant women (n=42). We divided the study group into three different subgroups: first trimester, second trimester and third trimester. Results: Serum ADA, ADA-1 and ADA-2 activities in healthy pregnant women were significantly lower than in nonpregnant women (p

Özet

Amaç: ADA insan dokularında yaygın bir dağılım göstermektedir. ADA immünolojik sistemin olgunlaşmasına, özellikle lenfoid hücrelerin çoğalma ve farklılaşmasına katkıda bulunur ve olgunlaşma işleminin farklı aşamalarında kritik bir rol oynar. ADA aktivitesi hücre-aracılı immünitenin değiştiği hastalıklarda değişmektedir. Bu çalışmada sağlıklı gebe kadınlarda serum total ADA ve ADA izoenzim (ADA-1 ve ADA-2) aktivitelerini inceledik ve gebelik boyunca ADA aktivitesinde değişikliklere neden olan hücre-aracılı immünitedeki değişikliklerin olası rollerini değerlendirdik. Gereç ve Yöntemler: Sağlıklı gebe kadınlarda (n=129) ve yaşça uyumlu sağlıklı gebe olmayan kadınlarda (n=42) serum total ADA, ADA-1 ve ADA-2 aktivitelerini ölçtük. Çalışma grubunu 1. trimester, 2.trimester ve 3. trimester olmak üzere üç farklı gruba ayırdık. Bulgular: Gebe grubunun ADA, ADA-1 ve ADA-2 değerleri, kontrol grubunun değerlerine göre anlamlı olarak daha düşük bulundu (ADA ve ADA-1 için p

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Cite This Article

DANE, B., BASINOĞLU, F., BAHADIR, G., DÖVENTAŞ, E. Y., TURKAL, R., ALTUNKAYNAK, E., KOLDAŞ, M. (2022). Gebelerde serum adenozin deaminaz ve izoenzim aktivitesi. Journal of the Turkish-German Gynecological Association, Cilt: 12 - Sayı: 4, 209–213. https://ajindex.com/articles/567715

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