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Journals / Haseki Tıp Bülteni / 2017 / Cilt: 55 - Sayı: 1

Association Between Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus in Pregnant Women

Gebelerde Ölçülen D Vitamini Seviyeleri ile Gestasyonel Diabetes Mellitus Riski Arasındaki İlişki

Seda ATEŞ
SERDAR AYDIN
AYŞE FİLİZ GÖKMEN KARASU
Banu DANE
Pages
15–20
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion:­Vitamin D deficiency in early pregnancy is not significantly associated with elevated risk of GDM.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To investigate whether maternal serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester is associated with an increased risk of gestational diabetes mellitus (GDM).
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Key Findings & Data:Twenty-five women with GDM and 208 controls without GDM were included in this study.
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Conclusion & Impact:Conclusion:­Vitamin D deficiency in early pregnancy is not significantly associated with elevated risk of GDM.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: To investigate whether maternal serum levels of 25-hydroxyvitamin D [25(OH)D] in the first trimester is associated with an increased risk of gestational diabetes mellitus (GDM). Methods: We conducted a cross-sectional study of a cohort of pregnant women who had undergone routine genetic multiple marker screening and subsequent glucose tolerance testing. Twenty-five women with GDM and 208 controls without GDM were included in this study. Plasma 25(OH)D concentrations were measured using liquid chromatography-tandem mass spectrometry. Results: Mean 25(OH)D concentrations at 11-14 weeks of gestation were not significantly different in women who subsequently developed GDM compared with those who did not (mean ± standard deviation: 13.96 9.05 versus 13.43±9.72; p=0.8). The prevalence of first-trimester severe 25(OH)D deficiency (<10 ng/mL) was similar between women with GDM and healthy controls (44% vs. 44.7%, respectively; p=0.9). The mean concentration of 25(OH)D slightly increased over the two gestational age windows both in women with GDM [mean ?25(OH)D: 0.25±5.8 ng/mL] and controls [mean ?25(OH)D: 0.84±12.84 ng/mL], but the difference was not statistically significant (p=0.8). Conclusion:­Vitamin D deficiency in early pregnancy is not significantly associated with elevated risk of GDM.

Özet

Birinci trimesterde ölçülen maternal 25-hidroksi D [25(OH)D] vitamini serum düzeylerinin gestasyonel diabetes mellitus (GDM) ile ilişkisinin araştırılması. Yöntemler: Bu kesitsel kohort çalışmayı birinci trimesterde rutin genetik tarama testi yapılan ve sonrasında glukoz tolerans testi uygulanan gebeler üzerinde yaptık. Gestasyonel diyabet tanısı alan 25 gebe ve gestasyonel diyabet tanısı almayan 208 gebe çalışmaya dahil edildi. Plazma 25(OH)D konsantrasyonları, sıvı kromatografisi-tandem kütle spektrometresi yöntemiyle ölçüldü. Bulgular: GDM gelişen gebelerin ve kontrol grubunun 11-14.gebelik haftalarında ölçülen ortalama 25(OH)D vitamini konsantrasyonları arasında anlamlı fark yoktu (sırasıyla ortalama ± standart deviasyon: 13,96±9,05 vs 13,43±9,72, p=0,8). Ortalama 25(OH)D konsantrasyonları, hem gestasyonel diyabetli gebelerde hem de kontrol grubunda iki ayrı gebelik haftası aralığında (11-14 gebelik haftası ve 24-28 gebelik haftası) hafifçe artmıştı [ortalama ?25(OH)D: 0,25±5,8 ng/mL ve ortalama ?25(OH)D: 0,84±12,84 ng/mL]; ancak bu fark istatistiksel olarak anlamlı değildi (p=0,8). Sonuç: Erken gebelik haftasında saptanan 25(OH)D vitamin eksikliği, GDM riski ile ilişkili değild.

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Cite This Article

ATEŞ, S., AYDIN, S., KARASU, A. F. G., DANE, B. (2017). Association Between Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus in Pregnant Women. Haseki Tıp Bülteni, Cilt: 55 - Sayı: 1, 15–20. https://ajindex.com/articles/267819

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