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Journals / Journal of the Turkish-German Gynecological Association / 2021 / Cilt: 22 - Sayı: 1

Analyses of soluble endoglin and matrixmetalloproteinase 14 using enzyme-linkedimmunosorbent assay in the diagnosis and assessmentof severity of early- and late-onset pre-eclampsia

Erbil KARAMAN
İlkay DOĞAN
Tuncay YÜCE
Ali OVAYOLU
Gamze OVAYOLU
Selver GÜLER
Pages
29–36
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The aim was to determine and compare the serum levels of s-ENG and MMP-14 in different groups of PrE patients and healthy subjects.Material and Methods: The study included 30 patients with late-onset preeclampsia (L-PrE) (group 1; gestational age ≥34 weeks), 33 patients with normal pregnancy (group 2; gestational age ≥34 weeks), 31 patients early-onset preeclampsia (E-PrE) (group 3; gestational age

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Abnormal trophoblastic invasion and impaired placentation have a crucial role in the etiopathogenesis of preeclampsia (PrE).
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Key Findings & Data:Trophoblastic cells are involved in invading the maternal decidua and remodelling of the spiral arteries with matrix metalloproteinase-14 (MMP14).
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Conclusion & Impact:The aim was to determine and compare the serum levels of s-ENG and MMP-14 in different groups of PrE patients and healthy subjects.Material and Methods: The study included 30 patients with late-onset preeclampsia (L-PrE) (group 1; gestational age ≥34 weeks), 33 patients with normal pregnancy (group 2; gestational age ≥34 weeks), 31 patients early-onset preeclampsia (E-PrE) (group 3; gestational age
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Abnormal trophoblastic invasion and impaired placentation have a crucial role in the etiopathogenesis of preeclampsia (PrE). Trophoblastic cells are involved in invading the maternal decidua and remodelling of the spiral arteries with matrix metalloproteinase-14 (MMP14). MMP-14 cleavage of endoglin releases its extracellular region, the soluble form of endoglin (s-ENG), into the maternal circulation. In PrE, there is a relationship between endothelial dysfunction and s-ENG concentration. The aim was to determine and compare the serum levels of s-ENG and MMP-14 in different groups of PrE patients and healthy subjects.Material and Methods: The study included 30 patients with late-onset preeclampsia (L-PrE) (group 1; gestational age ≥34 weeks), 33 patients with normal pregnancy (group 2; gestational age ≥34 weeks), 31 patients early-onset preeclampsia (E-PrE) (group 3; gestational age

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Cite This Article

KARAMAN, E., DOĞAN, İ., YÜCE, T., OVAYOLU, A., OVAYOLU, G., GÜLER, S. (2022). Analyses of soluble endoglin and matrixmetalloproteinase 14 using enzyme-linkedimmunosorbent assay in the diagnosis and assessmentof severity of early- and late-onset pre-eclampsia. Journal of the Turkish-German Gynecological Association, Cilt: 22 - Sayı: 1, 29–36. https://ajindex.com/articles/567359

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References (13)

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