Journals / Journal of Neurological Sciences (Turkish) / 2009 / Cilt: 26 - Sayı: 2

Parkinson hastalığında motor semptomların başlama tarafı ile kognitif disfonksiyon arasındaki ilişki

The relationship between cognitive dysfunction and the lateralization of the motor functions in parkinson's disease

Pages
179–184
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were no relationship between the type and the lateralization of the motor symptom and the cognitive dysfunction evaluation scales.Conclusion: Visuospatial perception impairment developes more often in patients whose motor symptoms start from the left side.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Parkinson's disease ( PD ) is a neurodegenerative disorder which starts with unilateral motor symptoms.
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Key Findings & Data:During the clinical period, cognitive functions may deteriorate and dementia may occur.
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Conclusion & Impact:There were no relationship between the type and the lateralization of the motor symptom and the cognitive dysfunction evaluation scales.Conclusion: Visuospatial perception impairment developes more often in patients whose motor symptoms start from the left side.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Parkinson's disease ( PD ) is a neurodegenerative disorder which starts with unilateral motor symptoms. During the clinical period, cognitive functions may deteriorate and dementia may occur. However, the relationship between the lateralization and the type of motor symptom and the development of cognitive dysfunction is controversial.Objectives: In this study, we investigated the relationship between the lateralization of the motor symptom and development of cognitive dysfunction in PD.Patients and Method: Fifty one parkinson patients were included to the study. The type of the motor symptom (rigidity and tremor) and the lateralization of this symptom were recorded. UPDRS, MMSE and cognitive dysfunction evaluation scales were performed.Results: Patients whose motor symptom started from the left side, had worse visuospatial perception (p: 0.02). UPDRS and MMSE scores of the patients had inverse relation. There were no relationship between the type and the lateralization of the motor symptom and the cognitive dysfunction evaluation scales.Conclusion: Visuospatial perception impairment developes more often in patients whose motor symptoms start from the left side.

Özet

Bilimsel zemin : Parkinson Hastalığı (PH) tek taraflı motor semptomlarla başlayan nörodejeneratif bir hastalıktır. Klinik süreç boyunca hastalarda kognitif fonksiyonlar bozulabilir ve demans gelişebilir. Ancak başlangıç motor semptomun tipi ve başlama tarafı ile kognitif disfonksiyon gelişmesi arasında ilişki tartışmalıdır.Amaç: Bu çalışmada PH' da ilk motor semptomun tipi ve başlama tarafı ile kognitif disfonksiyon gelişmesi arasında ilişki araştırıldı.Hastalar ve Yöntem : Bu çalışmaya 51 Parkinson hastası alındı. Hastalarda ilk motor semptomun tipi (rijidite, tremor ) ve başlama tarafı kaydedildi. Hastalara UPDRS, MMSE ve kognitif fonksiyonları değerlendirme ölçekleri uygulandı.Sonuçlar: Motor semptomları sol taraftan başlayan hastalarda vizüyospasiyal algının daha bozuk olduğu saptandı ( p: 0.02). Hastaların UPDRS ve MMSE skorları arasında ters ilişki eğilimi olduğu gözlendi. Başlangıç semptom ve tarafı ile diğer kognitif fonksiyon ölçekleri arasında ilişki saptanmadı.Yorum : Parkinson hastalığında vizüyospasiyal algılama bozukluğu, motor semptomları sol taraftan başlayan hastalarda daha sık gelişmektedir.

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Cite This Article

ŞİRİNOCAK, P. B., ZORLU, Y., ŞENER, U., ÖZÇELİK, M. M., TUNÇAY, N. (2022). Parkinson hastalığında motor semptomların başlama tarafı ile kognitif disfonksiyon arasındaki ilişki. Journal of Neurological Sciences (Turkish), Cilt: 26 - Sayı: 2, 179–184. https://ajindex.com/articles/565520

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References (14)

  1. Amick MM, Grace J, Chou KL. Body side of motor symptom onset in parkinson's disease associated with memory performance. Int J Neuropsychol Soc 2006;12:736-740
  2. Bayles KA, Tomoeda CK, Wood JA, Montgomery EB Jr, Cruz RF, Azuma T, McGeagh A. Change in cognitive function in idiopathic Parkinson's disease. Arch Neurol 1996; 53 (11):1140-1146
  3. Cooper JA, Sagar HJ, Jordan N, Harvey NS, Sullivan EV. Cognitive in impairment in early, untreated Parkinson's disease and its relationship to motor disability. Brain 1991;114: 2095-2122
  4. Emre M. What causes mental dysfunction in Parkinson's disease. Mov Disor 2003;18:63-71
  5. Hoehn MM, Yahr MD. Parkinsonism onset, progression and mortality. Neurology 1967;17:427- 442
  6. Iwasaki Y, Kinoshita M, Ikeda K, Takamiya K. Cognitive function in Parkinson's disease: In Relation to motor symptoms. Int J Neurosci 1989;47:295-300
  7. Katzen HL, Levin BE, Weiner W. Side and type of motor symptom influence cognition in parkinson's disease. Mov Disor 2006;21:1947-1953
  8. Lieberman AN. Point of view. Dementia in Parkinson's disease. Parkinsonism Relat Disord 1997;3: 151-158
  9. Litvan I, Mohr E, Williams J, Gomez C, Chase TN. Differential memory and executive functions in demented patients with Parkinson's and Alzheimer disease. JNNP 1991;54:25-29 10) Mayeux R, Chen J, Mirabello E, Marder K, Bell K, Dooneief G, Cote L, Stern Y. An estimate of the incidance of dementia in idiophatic parkinson's disease. Neurology 1990;40:1513-1517
  10. Mayeux R, Stern Y. Intellectuel impairment in parkinson's disease. Adv Neurol 1987;45:405-408 12) Pillon B, Boller F, Levy R, Dubois B. Cognitive deficits and dementia in parkinson's disease: In: Boller F, Cappa S. editors. Handbook of Neuropsychology. Amsterdam:Elsevier; 2001: ed:2. pp311-371 13) Purves D, Agustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, McNamara JO, Williams SM. Neuroscience. Sinauer Associates inc Massachusetts USA, 2004:ed: 3 pp 613-695
  11. Rowe JB, Hughes L, Ghosh BC, Eckstein D, Williams-Gray CH, Fallon S, Barker RA, Owen AM.Parkinson's disease and dopaminergic therapy – differential effects on movement reward and cognition. Brain 2008;131:2094-2105
  12. Tomer R, Levin BE, Weiner WJ. Side of onset of motor symptoms influences cognition in parkinson's disease: Ann Neurol 1993;34:579-584
  13. Verleden S, Vingerhoets G, Santens P. Heterogeneity of cognitive dysfunction in parkinson's Disease: A cohort study. Eur Neurol 2007;58:34-40
  14. Williams-Gray CH, Foltynie T, Bra