Genç yaş serebrovasküler hastalıkta etiyoloji

Key Findings & Data:Etiological diagnosis is very heteregenous including cardioembolism as the most common cause.Patients and Methods: Twenty-five young patients (age between 18-45 years) with cerebrovascular disease who were admitted to our University Hospital in the last two years were evaluated for their etiological diagnoses and risk factors.

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Conclusion & Impact:Absence of classification for young adults and insufficiency at genetic research opportunities causes important limitations in clinical evaluation.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Scientific Background: The incidence of cerebrovascular diseases (CVD) among young adults is approximately 2-11/100.000. Etiological diagnosis is very heteregenous including cardioembolism as the most common cause.Patients and Methods: Twenty-five young patients (age between 18-45 years) with cerebrovascular disease who were admitted to our University Hospital in the last two years were evaluated for their etiological diagnoses and risk factors. They were classified according to the Trial of Org 10172 in acute stroke treatment (TOAST) classification. A comparison according to gender and age was done.Results: There were ten male (40%) and fifteen female (60%) patients. The mean age of the patients was 34.7±7.8 (20-45) years. The most frequent etiological diagnosis was cardioembolism related CVD (32%). Other etiological diagnoses were: Other determined causes 24% lacunar infarct 16%, large artery atherosclerosis 4% and undetermined 24%. The most common reason for cardioembolism was valvulopathy due to rheumatic fever (75%). Comparison of risk factors amongst genders and different age groups were not statistically significant (p>0.05).Conclusion: Despite complete evaluation, etiological diagnosis can not be determined in 24% of patients. Absence of classification for young adults and insufficiency at genetic research opportunities causes important limitations in clinical evaluation.

Özet

Bilimsel zemin: Genç erişkinlerde serebrovasküler hastalık (SVH) insidansı yaklaşık 100.000'de 2-11'dir. Etiyolojide başta kardiyoembolizm olmak üzere geniş bir yelpaze yer alır.Hastalar ve Metod: İki yıllık süreçte kliniğimizde takip edilen 25 genç serebrovasküler hastası (18-45 yaş) etiyolojik özellikleri ve risk faktörleri açısından Trial of Org 10172 in acute stroke treatment (TOAST) sınıflamasına göre sınıflandırıldı, cinsiyet ve yaş gruplarına ayrılarak incelendi.Sonuçlar: Yirmibeş hastanın 10'u erkek (%40), 15'i kadındı (%60). Hastaların yaş ortalaması 34.7±7.8 (20-45) idi. Etiyolojide en sık kardiyoembolizm kaynaklı SVH tespit edildi (%32). Tanımlanmış diğer nedenler %24, laküner infarkt %16, büyük damar aterosklerıozu %4, nedeni saptanamayan grup %24 oranındaydı. Kardiyoembolizmin en sık sebebi romatizmal kalp kapak hastalığıydı (%75). Cinsiyetler ve yaş grupları arasında yapılan risk faktörleri karşılaştırmasında anlamlı fark tespit edilmedi (p>0.05).Yorum: Tüm inceleme yöntemlerine rağmen hastaların %24'ünde etiyolojik faktör tesbit edilememiştir. Genç olgulara yönelik sınıflamanın olmayışı ve genetik araştırma olanaklarının yetersiz oluşu klinik değerlendirmede önemli kısıtlılıklar getirmektedir.

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Cite This Article

ÖNCEL, Ç., BİR, L. S., OĞUZHANOĞLU, A., ERÖZ, Ö. (2022). Genç yaş serebrovasküler hastalıkta etiyoloji. Journal of Neurological Sciences (Turkish), Cilt: 26 - Sayı: 1, 12–17. https://ajindex.com/articles/565478

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