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Journals / Journal of Neurological Sciences (Turkish) / 2011 / Cilt: 28 - Sayı: 4

Neuroprotective Effects of Mannitol And Vitamin C on Crush Injury of Sciatic Nerve; An Experimental Rat Study

Mannitol ve C Vitamininin Siyatik Sinir Crush Hasarı Üzerine Nöroprotektif Etkileri; Deneysel Sıçan Çalışması

Mehmet ŞENOĞLU
Davut ÖZBAĞ
Ergül Belge KURUTAŞ
Harun ÇIRALIK
Zeki YILMAZ
Pages
538–551
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Lipid peroxide product malondialdehyde (MDA), superoxide dismutase(SOD) and catalase (CAT) enzyme activities were measured.After mannitol treatment tissue SOD and CAT activities increased and MDA level decreasedsignificantly, at the early period (group III, p < 0.05) and on the late period (group IV, p

📌 3 Key Takeaways

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Objective & Hypothesis:In this experimental sciatic nerve crush injury model study, early and late neuroprotectiveefficacy of mannitol and vitamin C.In this study 60 male rats were used.
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Key Findings & Data:The subjects were divided into 6 groups as Sham group(Group 1), Control group (Group 2), 1. hour mannitol group (Group 3), 1. hour vitamin Cgroup (Group 4), 24. hour mannitol group (Group 5) and 24. hour vitamin C group (Group6).At the end of the experimental period, tissue samples were taken for histopathological andbiochemical studies.
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Conclusion & Impact:Lipid peroxide product malondialdehyde (MDA), superoxide dismutase(SOD) and catalase (CAT) enzyme activities were measured.After mannitol treatment tissue SOD and CAT activities increased and MDA level decreasedsignificantly, at the early period (group III, p < 0.05) and on the late period (group IV, p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this experimental sciatic nerve crush injury model study, early and late neuroprotectiveefficacy of mannitol and vitamin C.In this study 60 male rats were used. The subjects were divided into 6 groups as Sham group(Group 1), Control group (Group 2), 1. hour mannitol group (Group 3), 1. hour vitamin Cgroup (Group 4), 24. hour mannitol group (Group 5) and 24. hour vitamin C group (Group6).At the end of the experimental period, tissue samples were taken for histopathological andbiochemical studies. Lipid peroxide product malondialdehyde (MDA), superoxide dismutase(SOD) and catalase (CAT) enzyme activities were measured.After mannitol treatment tissue SOD and CAT activities increased and MDA level decreasedsignificantly, at the early period (group III, p < 0.05) and on the late period (group IV, p

Özet

Giriş: Bu çalışmada siyatik sinir crush hasarı modelinde, mannitol ve C vitamininin erken vegeç dönemde nöroprotektif etkinliği araştırıldı.Materyal ve Metod: Bu çalışmada 60 adet sıçan kullanıldı. Denekler; Sham (grup 1) Kontrol(grup 2), Mannitol ( 0.5 gr/kg ) 1. saat (grup 3), C vitamini (100mg/kg) 1. Saat (grup 4),Mannitol 24. Saat (grup 5) ve C vitamini 24. Saat (grup 6) olmak üzere 6 gruba ayrıldı. Tümgruplarda biyokimyasal çalışmalar ve histopatolojik inceleme için siyatik sinir doku örneklerialındı. Süperoksit Dismutaz (SOD) ve Katalaz (CAT) enzim aktiviteleri ve lipid peroksitürünü olan Malondialdehit (MDA) düzeyi ölçüldü.Bulgular: Mannitol tedavisi verilen gruplar (grup 3, grup 5) kontrol (grup 2) grubuylakarşılaştırıldığında SOD ve CAT enzim aktivitelerinin erken (grup 3, p

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Cite This Article

ŞENOĞLU, M., ÖZBAĞ, D., KURUTAŞ, E. B., ÇIRALIK, H., YILMAZ, Z. (2022). Neuroprotective Effects of Mannitol And Vitamin C on Crush Injury of Sciatic Nerve; An Experimental Rat Study. Journal of Neurological Sciences (Turkish), Cilt: 28 - Sayı: 4, 538–551. https://ajindex.com/articles/565354

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