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Journals / Journal of Neurological Sciences (Turkish) / 2011 / Cilt: 28 - Sayı: 4

Royal Jelly in the Prevention of Radiation-Induced Brain Damages

Radyasyonun İndüklediği Beyin Hasarına Karşı Arı Sütünün Koruyucu Etkisi

Erkan GÖCEN
Yasemin Benderli CİHAN
Vedat ARSAV
Pages
475–486
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

At the seventh day of study, when rats were under ketamine anesthesia samples ofbrain tissues were taken and biochemical and microscopic examination after sacrification.Results: An increase in brain tissue malondialdehyde (MDA) concentrations (P

📌 3 Key Takeaways

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Objective & Hypothesis:Background and aims: Radiotherapy is frequently used for brain tumor treatment and isknown to cause of brain damage.
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Key Findings & Data:Thepurpose of this study is to investigate the possible protective role of royal jelly on radiation- induced brain damage.Design: In the present study, thirty-two adult male Dawley rats, 8-12 weeks of age andweighing 275±35 grams were randomly divided into four groups each group compressedeight animals: group 1: control (C), group 2: irradiated rats (RT), group 3: irradiated rats withoral royal jelly 50 mg/kg per day for 7 days (RT+RJ50), group 4: oral royal jelly 50 mg/kgper day for 7 day (RJ50).
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Conclusion & Impact:At the seventh day of study, when rats were under ketamine anesthesia samples ofbrain tissues were taken and biochemical and microscopic examination after sacrification.Results: An increase in brain tissue malondialdehyde (MDA) concentrations (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and aims: Radiotherapy is frequently used for brain tumor treatment and isknown to cause of brain damage. Many agents have been used for neuroprotection. Thepurpose of this study is to investigate the possible protective role of royal jelly on radiation- induced brain damage.Design: In the present study, thirty-two adult male Dawley rats, 8-12 weeks of age andweighing 275±35 grams were randomly divided into four groups each group compressedeight animals: group 1: control (C), group 2: irradiated rats (RT), group 3: irradiated rats withoral royal jelly 50 mg/kg per day for 7 days (RT+RJ50), group 4: oral royal jelly 50 mg/kgper day for 7 day (RJ50). Sprague Dawley rats were irradiated with 22 Gy gamma radiationdelivered to total cranium. Royal jelly was administered before and after irradiation per dayfor 7 days. At the seventh day of study, when rats were under ketamine anesthesia samples ofbrain tissues were taken and biochemical and microscopic examination after sacrification.Results: An increase in brain tissue malondialdehyde (MDA) concentrations (P

Özet

Amaç: Radyoterapi beyin tümörleri tedavisinde sık kullanılan tedavi modalitesidir.Radyoterapinin beyinde nöron hücrelerinde hasar yaptığı bilinmektedir. Bu hasarı azaltmakiçin birçok ajanlar araştırılmaktadır. Bu çalışmada, beyin ışınlaması yapılan ratlarda,radyasyonun beyinde yaptığı hasara karşı bir antioksidan olan arı sütünün koruyucu etkisiolup olmadığı araştırıldı.Gereç ve yöntemler: Çalışmaya 32 adet, 8 12 haftalık yaşta ve 275±35 gram ağırlığındaSprague-Dawley dişi rat alındı. Araştırmada hayvanlar 4 gruba ayrıldı; grup 1: kontrol grubu(K), grup 2: sadece beyine ışınlama yapılan (RT); grup 3: beyine ışınlama ile birlikte 50mg/kg arı sütü verilen (RT+AS50); grup 4: sadece 50 mg/kg arı sütü verilen (AS50) grupolarak belirlendi. Radyoterapi sıçanlar ketamin anestezisi altında iken total kraniale, tekfraksiyonda ve doz 22 Gy olarak verildi. Arı sütünün ilk dozu ışınlamadan 30 dakika önce,diğer dozlar günde bir defa olmak üzere yedi gün boyunca topikal olarak verildi. Çalışmanın7. gününde ratlar ketamin anestezisi altında iken sakrifiye edildikten sonra beyin dokuörnekleri alındı. Beyin dokusunda antioksidan aktivite analizleri ve histopatolojik incelemeyapıldı.Bulgular: RT grubu, kontrol grubu ile kıyaslandığında malondialdehit (MDA) seviyesindeartış; katalaz (CAT) ve süperoksit dismutaz (SOD) aktivitesinde önemli düşme gözlendi(P

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Cite This Article

GÖCEN, E., CİHAN, Y. B., ARSAV, V. (2022). Royal Jelly in the Prevention of Radiation-Induced Brain Damages. Journal of Neurological Sciences (Turkish), Cilt: 28 - Sayı: 4, 475–486. https://ajindex.com/articles/565303

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