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Journals / Journal of Neurological Sciences (Turkish) / 2013 / Cilt: 30 - Sayı: 1

Magnezyum Sülfat Serebral İskemik Hasarlanmayı Önler mi? Deneysel Çalışma ve Nöroradyolojik Kanıt

Can Magnesium Sulphate Prevent Cerebral Ischemic Injury? An Experimental Study and Neuroradiological Evidence

Cem ATABEY
Nail BULAKBAŞI
Serdar KAHRAMAN
Soner ŞAHİN
Pages
30–39
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Total infarct volumes were significantly reduced in both the pre-occlusive andpost-occlusive MgSO4 treatment groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:This study was designed to investigate whether magnesium sulphate prevents cerebralischemic injury on an experimental rat model.
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Key Findings & Data:Forty Sprague-Dawley rats were divided into 4groups: I) the sham group; II) the group to which saline was applied prior to ischemia(control); III) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes beforeischemia; IV) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes afterischemia.
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Conclusion & Impact:Total infarct volumes were significantly reduced in both the pre-occlusive andpost-occlusive MgSO4 treatment groups (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was designed to investigate whether magnesium sulphate prevents cerebralischemic injury on an experimental rat model. Forty Sprague-Dawley rats were divided into 4groups: I) the sham group; II) the group to which saline was applied prior to ischemia(control); III) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes beforeischemia; IV) the group that received MgSO4 (90 mg/ kg) intraperitoneally 30 minutes afterischemia. Infarct volumes were measured in all the rat groups by the use of MRI subsequentlyanalyzed by the Workstation: Philips Easy Vision 5.2.1.1 Measurement analysis program.Total infarct volumes in the ischemic group that received saline without MgSO4, in the groupthat received MgSO4 after occlusion of the MCA and in the group that received MgSO4before MCA occlusion were 231.7±34.03 mm3, 158.85±32.16 mm3 and 87.35±22.27 mm3 respectively. Total infarct volumes were significantly reduced in both the pre-occlusive andpost-occlusive MgSO4 treatment groups (p

Özet

Bu çalışma, deneysel sıçan modelinde magnezyum sülfatın serebral iskemik hasarlanmanınönlenmesinin araştırılması için tasarlanmıştır. Kırk adet Sprague-Dawley sıçan dört grubaayrıldı: 1) Sham grup 2) İskemi öncesi tuzlu su uygulanan grup (kontrol) 3) İskemiden 30dakika öncesi intraperitoneal olarak MgSO4 (90 mg/ kg) uygulanan grup 4) İskemiden 30dakika sonra intraperitoneal olarak MgSO4 (90 mg/ kg) uygulanan grup. Toplam infarkthacimleri tüm gruplar için MRG eşliğinde Workstation: Philips Easy Vision 5.2.1.1Measurement analiz programı kullanılarak ölçüldü. Toplam infarkt hacimleri, tuzlu suuygulanan MgSO4 verilmemiş iskemik grup, Orta Serebral Arter oklüzyonu uygulanmasısonrası ve öncesinde MgSO4 uygulanan gruplarda sırasıyla 231.7±34.03 mm3, 158.85±32.16mm3 ve 87.35±22.27 mm3 bulundu. Toplam infarkt hacimleri oklüzyon öncesi ve sonrasıgruplarının herikisinde de anlamlı olarak azaldı (p

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Cite This Article

ATABEY, C., BULAKBAŞI, N., KAHRAMAN, S., ŞAHİN, S. (2022). Magnezyum Sülfat Serebral İskemik Hasarlanmayı Önler mi? Deneysel Çalışma ve Nöroradyolojik Kanıt. Journal of Neurological Sciences (Turkish), Cilt: 30 - Sayı: 1, 30–39. https://ajindex.com/articles/565204

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References (13)

  1. Altura BT, Memon ZI, Zhang A, Cheng TP, Silverman R, Cracco RQ, Altura BM. Low levels of serum ionized magnesium are f ound in p atients early af ter stroke which results in rap id elevation in cytosolic f ree calcium and sp asm in cerebral vascular muscle cells. Neuroscience Letter 1997;230:37-40
  2. Altura BT. Typ e-A behavior and coronary vasosp asm: a p ossible role of hyp omagnesemia. Med Hyp otheses 1980;6:753–7
  3. Bareyrei FM, Saatman KE, Helf aer MA, Sinson G, Weisser JD, Brown AL. Alterations in ionized and total blood magnesium af ter exp erimental traumatic brain inj ury: relationship to neurobehavioral outcome and neurop rotective eff iciency of magnesium chloride. J Neurochem 1999;73:271-80 4. Berger R, Jensen A, Krieglstein J, Steigelman JP. Eff ects of acute asp hyxia on brain energy metabolism in f etal guinea p igs near term. J Dev Physiol 1991;6: 9-11
  4. Cernak I, Savic VJ, Kotur V, Velij ovic M, Grbovic D. Characterization of p lasma magnesium concentration and oxidative stress f ollowing graded traumatic brain inj ury in humans. J Neurotrauma 2000;17:53-68
  5. Choi D W. Excitotoxic cell-death. J Neurobiol 1992;23:1261–76
  6. Dorhout Mees SM, Algra A, Vanderto WP et al: Magnesium f or aneurysmal subarachnoid haemorrhage (MASH-2): a randomised p lacebo-controlled trial. Lancet 2012; 380(9836):44-9 8. Ebel H, Gunther T. Magnesium metabolism: a review. J Clin Chem Clin Biochem 1980;28: 257-70
  7. Feldman Z, Gurevitch B, Artru AA, Opp enheim A, Shohami E, Reichenthal E, Shap ira Y. Eff ect of magnesium given 1 hour af ter head trauma on brain edema and neurological outcome. J Neurosurg 1996;85:131–7
  8. Garcia JH. Exp erimental cerebral stroke: a review. Stroke 1984;15:5-14 11. Garf inkel L, Garf inkel D. Magnesium regulation of the glycolytic p athway and the enzymes involved. Magnesium 1985;4:60–72
  9. Ginsberg MD. Neurop rotection f or ischemic stroke: p ast, p resent and f uture. Neurop harmacology. 2008;55:363-89
  10. Heath DL, Vink R. Blood f ree magnesium concentration declines f ollowing graded exp erimental traumatic brain inj ury. Scand J Clin Invest 1998;58:161-6
  11. Heath DL, Vink R. Delayed therapy with magnesium up to 24 h f ollowing traumatic brain inj ury imp roves motor outcome. J Neurosurg 1999;90:504-9
  12. Heath DL, Vink R. Op timization of magnesium therapy af ter severe diff use axonal brain inj ury in rats. J Pharmacol Exp Ther. 1999;288:1311- 6
  13. Heath DL, Vink R. Traumatic brain axonal inj ury p roduces