SavedAdd your journal

Journals / Journal of Neurological Sciences (Turkish) / 2013 / Cilt: 30 - Sayı: 3

Migren Hastalarında CHRNA4 Gen Polimorfizmilerinin, Oksidatif DNA Hasarı ve Oksidatif Stres Markır Seviyelerinin Analizi

Association Analysis of CHRNA4 Gene Polymorphisms and Levels of Marker of Oxidative DNA Damage and Oxidative Stress in Migraine Patients

Banu ÖZEN
Sevim ÇELİK KARAKAŞ
Fürüzan KÖKTÜRK
Zehra SAFİ ÖZ
Ümmühani TÜRKCÜ ÖZEL
Tuba EDGÜNLÜ GÖKDOĞAN
Pages
477–486
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Also, 8-oxo2dG and AOPP levelswere measured in plasma of migraine patients.Results: As a result, we were found a significant relationship between rs1044394polymorphism of CHRNA4 gene and migraine patients without aura (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Migraine is a primary headache syndrome which has been a genetic factor in quitecomplex etiopathogenesis.
📊
Key Findings & Data:The aim of our study is to investigate the relationship between polymorphisms ofCHRNA4 gene and migraine and determined to oxidative DNA damage and oxidative stresswith detection of 8-oxo2dG and AOPP levels in plasma of patients with migraine.Methods: In our study, DNA was obtained from migraine patients (n=79) and unrelatedhealthy persons (n=68).
💡
Conclusion & Impact:Also, 8-oxo2dG and AOPP levelswere measured in plasma of migraine patients.Results: As a result, we were found a significant relationship between rs1044394polymorphism of CHRNA4 gene and migraine patients without aura (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Migraine is a primary headache syndrome which has been a genetic factor in quitecomplex etiopathogenesis. The mechanisms underlying the migraine have not been clearlyenlightened. The aim of our study is to investigate the relationship between polymorphisms ofCHRNA4 gene and migraine and determined to oxidative DNA damage and oxidative stresswith detection of 8-oxo2dG and AOPP levels in plasma of patients with migraine.Methods: In our study, DNA was obtained from migraine patients (n=79) and unrelatedhealthy persons (n=68). Alleles and genotypes of CHRNA4 gene polymorphisms (rs1044394,rs1044393) were determined with PCR and RFLP methods. Also, 8-oxo2dG and AOPP levelswere measured in plasma of migraine patients.Results: As a result, we were found a significant relationship between rs1044394polymorphism of CHRNA4 gene and migraine patients without aura (p

Özet

Amaç: Migren, oldukça karmaşık bir genetik etyopatogenezi olan primer başağrısısendromudur. Migrenin altında yatan mekanizmalar henüz net olarak aydınlatılamamıştır.Çalışmamızın amacı, CHRNA4 geni polimorfizmleri ile migren arasındaki ilişkininaraştırılması ve migren hastalarının plazmalarında 8-oxo2dG ve AOPP düzeylerinin tespiti ileoksidatif DNA hasarı ve oksidatif stresin belirlenmesidir.Method: Çalışmamızda, migren hastaları (n = 79) ve ilişkisiz sağlıklı bireylerden (n = 68)DNA elde edildi. CHRNA4 geni rs1044393 ve rs1044394 polimorfizmlerine ait allel vegenotipler PCR ve RFLP yöntemleri ile belirlendi. Ayrıca, migrenli hastaların plazmasında 8- oxo2dG ve AOPP düzeyleri ölçüldü.Bulgular: Çalışmamızın sonucunda, aurasız migren hastaları ile CHRNA4 geni rs1044394polimorfizmi arasında anlamlı bir ilişki tespit edildi (p

🔖

Cite This Article

ÖZEN, B., KARAKAŞ, S. Ç., KÖKTÜRK, F., ÖZ, Z. S., ÖZEL, Ü. T., GÖKDOĞAN, T. E. (2022). Migren Hastalarında CHRNA4 Gen Polimorfizmilerinin, Oksidatif DNA Hasarı ve Oksidatif Stres Markır Seviyelerinin Analizi. Journal of Neurological Sciences (Turkish), Cilt: 30 - Sayı: 3, 477–486. https://ajindex.com/articles/565202

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Alderman CJ, Shah S, Foreman JC. The role of advanced oxidation p rotein p roducts in regulation od dendritic cell f unction. Free Radical Biol Med 2002; 32: 377-385
  2. Bernecker C, Ragginer C, Fauler G, et al. Oxidative stress is associated with migraine and migraine-related metabolic risk in f emales. Eur J Neurol 2011; 18: 1233-9
  3. Bockowski L, Sobaniec W, Kulak W, et al. Serum and intraerythrocyte antioxidant enzymes and lip id p eroxides in children with migraine. Pharmacol Rep 2008; 60: 542-548
  4. Carrera P, Stenirri S, Ferrari M, et al. Familial hemip legic migraine: a ion channel disorder. Brain Res Bull 2001; 56: 239-241
  5. Chou IC, Lee CC, Huang CC, Wu JY, et al. Association of the neuronal nicotinic acetylcholine recep tor subunit alp ha4 p olymorp hisms with f ebrile convulsions. Ep ilepsia 2003; 44: 1089-93
  6. Colson NJ, Lea RA, Quinlan S, Griff iths LR. The role of vascular and hormonal genes in migraine suscep tibility. Mol Genet Metab 2006; 88: 107-113
  7. Dorszewska J, Florczak J, Rózycka A, et al. Polymorp hisms of the CHRNA4 gene encoding the alp ha4 subunit of nicotinic acetylcholine recep tor as related to the oxidative DNA damage and the level of ap op totic p roteins in lymp hocytes of the p atients with Alzheimer's disease. DNA Cell Biol 2005; 24: 786-94
  8. Dorszewska J, Florczak J, Rozycka A, et al. Oxidative DNA damage and level of thiols as related to p olymorp hisms of MTHFR, MTR, MTHFD1 in Alzheimer's and Parkinson's diseases. Acta Neurobiol Exp 2007; 67: 113- 29
  9. Fernandez F, Colson NJ, Griff iths LR. Pharmacogenetics of migraine: Genetic variants and their p otential role in migraine therapy. Pharmacogenomics 2007; 8: 609-622
  10. Grosso S, Longini M, Rodriguez A, et al. Oxidative stress in children aff ected by ep ilep tic encephalop athies. J Neurol Sci 2011;15: 103-6
  11. Guney Y, U. Ozel, O. Mertoglu, et al. Serum AOPP, selenium and vitamin E levels af ter irradiation. Turkish Journal of Cancer 2006; 36: 19-22
  12. Gup ta R, Pathak R, Bhatia MS, et al. Comp arison of oxidative stress among migraineurs, tension-typ e headache subj ects, and a control group. Ann Indian Acad Neurol 2009; 12: 167-72
  13. Hanasand M, Omdal R, Norheim KB, et al. Imp roved detection of advanced oxidation p rotein p roducts in p lasma. Clin Chim Acta 2012; 413: 901-6
  14. Haut SR, Bigal ME, Lip ton RB. Chronic disorders withep isodic manif estations: f ocus on ep ilepsy and migraine. Lancet Neurol 2006; 5: 148-157
  15. Headache Clas