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Journals / Journal of Neurological Sciences (Turkish) / 2013 / Cilt: 30 - Sayı: 4

Periferik Sinir Kesi Tamirinde Klasik Sütur Tekniği ile Siyanoakrilat Uygulamasının Regenerasyon Üzerine Etkilerinin Araştırılması (Hayvan Deneyi)

Assessment of Regeneration in Peripheral Nerve Lesıon Compared With Conventional Suture Technique and Using Cyanoacrylate ( Anımal Experiment)

İdiris ALTUN
Murat YILMAZ
Orhan KALEMCİ
Harun ÇIRALIK
Kemal YÜCESOY
Kasım Zafer YÜKSEL
Pages
756–766
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

However, it was found that there was astatistically significant difference regarding grade results of vacuolar degeneration, fibrosisand foreign body type tissue reaction between control group and classical suturing,cyanoacrylate or combined groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, it was aimed to assess effect of classical micro-suturing techniques combinedwith cyanoacrylate, used in nerve repair, on nerve regeneration in histopathological mannerand to evaluate whether it could be safely used in peripheral nerve surgery.Adult Wistar-Albino female rats were used in this study.
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Key Findings & Data:Animals were assigned into 4 groupsfor surgical processes as follows:Group 1: Control group (n=7); External circumferential neurolysisGroup 2: Experiment group (n=7); Repair with 4 epineural sutures.Group 3: Experiment group (n=7); Repair with cyanoacrylateGroup 4: Experiment group (n=7); combined groupHistopathologically, it was seen that there was no vacuolar degeneration, foreign body typetissue reaction or fibrosis in the nerves of subjects in the control group.
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Conclusion & Impact:However, it was found that there was astatistically significant difference regarding grade results of vacuolar degeneration, fibrosisand foreign body type tissue reaction between control group and classical suturing,cyanoacrylate or combined groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this study, it was aimed to assess effect of classical micro-suturing techniques combinedwith cyanoacrylate, used in nerve repair, on nerve regeneration in histopathological mannerand to evaluate whether it could be safely used in peripheral nerve surgery.Adult Wistar-Albino female rats were used in this study. Animals were assigned into 4 groupsfor surgical processes as follows:Group 1: Control group (n=7); External circumferential neurolysisGroup 2: Experiment group (n=7); Repair with 4 epineural sutures.Group 3: Experiment group (n=7); Repair with cyanoacrylateGroup 4: Experiment group (n=7); combined groupHistopathologically, it was seen that there was no vacuolar degeneration, foreign body typetissue reaction or fibrosis in the nerves of subjects in the control group. Moreover, it wasfound that there were findings of vacuolar degeneration, foreign body type tissue reaction andfibrosis in all experiments group in a similar manner. However, it was found that there was astatistically significant difference regarding grade results of vacuolar degeneration, fibrosisand foreign body type tissue reaction between control group and classical suturing,cyanoacrylate or combined groups (p

Özet

Bu çalışmada, sinir tamirinde siyanoakrilat uygulaması ile klasik mikrosütur tekniklerinin,sinir rejenerasyonuna etkisinin histopatolojik olarak değerlendirilmesi ve periferik sinircerrahisi tedavisinde güvenli bir şekilde kullanılıp kullanılamayacağının araştırılmasıamaçlanmıştır.Çalışmada Wistar Albino cinsi erişkin dişi sıçanlar kullanılmıştır. Sağ bacak siyatik siniriserbestleştirilen deney hayvanları cerrahi işlemler için 4 ayrı gruba ayrılmıştır.Grup 1: Kontrol grubu (n=7): Eksternal sirkumferensiyel nöroliz.Grup 2: Deney grubu (n=7): Dört adet epinöral dikiş ile onarım.Grup 3: Deney grubu (n=7): Siyanoakrilat ile onarımGrup 4: Deney grubu (n=7): İki adet epinöral dikiş ile onarım + siyanoakrilat ile onarım(kombine grup )Altı haftalık takip sonrası sinirlerin makroskopik ve histopatolojik değerlendirmesiyapılmıştır.Histopatolojik olarak, kontrol grubundaki deneklerinin sinir liflerinde vakuolar dejenerasyon,yabancı cisim tipi doku reaksiyonu ve fibrozis görülmemiştir. Kontrol grubu dışındaki,deneysel grupların sinir liflerinde vakuolar dejenerasyon, yabancı cisim tipi doku reaksiyonuve fibrozis bulguları birbirine benzer şekilde bulunmuştur. Ancak vakuolar dejenerasyon,fibrosiz ve yabancı cisim tipi doku reaksiyonu grade sonuçları bakımından kontrol grubu ileklasik sütur, siyanoakrilat, kombine grubları karşılaştırıldığında aralarında istatistiksel olarakanlamlı farkın olduğu belirlenmiştir ( p

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Cite This Article

ALTUN, İ., YILMAZ, M., KALEMCİ, O., ÇIRALIK, H., YÜCESOY, K., YÜKSEL, K. Z. (2022). Periferik Sinir Kesi Tamirinde Klasik Sütur Tekniği ile Siyanoakrilat Uygulamasının Regenerasyon Üzerine Etkilerinin Araştırılması (Hayvan Deneyi). Journal of Neurological Sciences (Turkish), Cilt: 30 - Sayı: 4, 756–766. https://ajindex.com/articles/565187

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