Menenjiomlarda Histopatolojik Özelliklerin Gözden Geçirilmesi: 125 Olgu

Key Findings & Data:The aim of this study was to evaluateclinical and histopathological parameters in meningiomas, find out significant factors impacton recurrence free survival.Materials and Methods: 125 consecutive meningioma cases diagnosed at Izmir TepecikTraining and Research Hospital between 2007 and 2012 were selected.

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Conclusion & Impact:We found statistically significant resultsbetween parenchymal invasion, necrosis, Ki67 index, histologic subtype and grade (p

🔬Design:Review & Systematic Survey

📍Scope:2007 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Meningiomas are extremely common tumors originating from meningealcoverings of the brain and spinal cord. Histopathological examination and grading ofmeningiomas give valuable prognostic information. The aim of this study was to evaluateclinical and histopathological parameters in meningiomas, find out significant factors impacton recurrence free survival.Materials and Methods: 125 consecutive meningioma cases diagnosed at Izmir TepecikTraining and Research Hospital between 2007 and 2012 were selected. Histopathological andclinical features were reevaluated. Follow up radiology records were reviewed to determineresidual and recurrent tumor.Results: Female/ male ratio was 2/1, mean age was 59.5. Meningothelial (58.4%), transitional(16%), fibrous (4.8%) subtypes were most frequent ones. Of the 125 cases, 64.8% werelocated in cerebral convexity, 12% were in sphenoid wing. Grade distrubution was as follows:grade I (89.6%), grade II (9.6%), grade III (0.8%). We found statistically significant resultsbetween parenchymal invasion, necrosis, Ki67 index, histologic subtype and grade (p

Özet

Amaç: Menenjiomlar beyin ve spinal kordun meningeal örtüsünden köken alan ve sık görülentümörlerdir. Histopatolojik özellikler ve derece menenjiomların davranışı hakkında önemliprognostik veri sağlar. Bu çalışmada menenjiomların klinik ve histopatolojik özellikleri ilehastalıksız sağkalımı etkileyen prognostik parametreleri araştırdık.Materyal-Metod: 2007-2012 yılları arasında İzmir Tepecik Eğitim Araştırma Hastanesi'ndetanı almış 125 menenjiom olgusu randomize seçildi. Histopatolojik ve klinik özellikler tekrardeğerlendirildi. Takip radyoloji raporları rezidü ve rekürren tümör açısından gözden geçirildi.Bulgular: Kadın/erkek oranı 2/1, ortalama yaş 59.5 olarak bulundu. Meningotelyal (%58.4),transizyonel (%16), fibröz (%4.8) menenjiom en sık görülen histolojik alt tiplerdi. Olguların%89.6'sı derece I, %9.6'sı derece II, %0.8'i derece III menenjiomlardı. Derece ile histolojik alttip, parankimal invazyon, mitoz, Ki67 proliferasyon indeksi arasında istatistiksel olarakanlamlı sonuç bulundu (p

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Cite This Article

KUCUK, U., CAKIR, E., KESKIN, E., BINATLI, O., BAYOL, U., PALA, E. E. (2022). Menenjiomlarda Histopatolojik Özelliklerin Gözden Geçirilmesi: 125 Olgu. Journal of Neurological Sciences (Turkish), Cilt: 31 - Sayı: 4, 699–708. https://ajindex.com/articles/565078

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References (13)

Abramovich CM, Prayson RA. MIB-1 labeling indices in benign, aggressive, and malignant meningiomas: A study of 90 tumors. Hum Pathol 1998
14201427. PMID:9865827 2. Amatya VJ, Takeshima Y, Sugiyama K et al. Immunohistochemical study of Ki-67 (MIB-1), p 53 p rotein, p 21WAF1, and p 27KIP1 exp ression in benign, atyp ical, and anap lastic meningiomas. Hum Pathol 2001
970975. PMID:11567227 3. Bruna J, Brell M, Ferrer I, et al. Ki-67 p rolif erative index p redicts clinical outcome in p atients with atyp ical or anap lastic meningioma. Neurop athology 2007
114 120. PMID:17494511 4. CBTR US (2011). Primary brain and central nervous system tumors diagnosed in the United States, 2004-2007. Central Brain Tumor Registry of the United States. 5. Claus EB, Bondy ML, Schildkraut JM, et al. Ep idemiology of intracranial meningioma. Neurosurgery 2005
PMID:16331155 6. Durand A, Labrousse F, Jouvet A, et al. WHO grade II and III meningiomas: a study of p rognostic f actors. J Neurooncol 2009
367375. PMID:19562258 7. Harrison MJ, Wolf e DE, Lau TS, et al. Radiation-induced meningiomas: exp erience at the Mount Sinai Hosp ital and review of the literature. J Neurosurg 1991
56474. PMID:1885974 8. Karabaglı P, Sav A. Prolif erative indices (MIB- 1) in meningiomas: correlation with the histological subtyp es and grades. Journal of Neurological Sciences (Turkish) 2006
Ko K W, Nam DH, Kong DS, et al. Relationship between malignant subtyp es of meningioma and clinical outcome. J Clin Neurosci 2007
747753. PMID:17499508 10. Louis DN, Ramesh V, Gusella JF. Neurop athology and molecular genetics of neurof ibromatosis 2 and related tumors. Brain Pathol 1995
16372. PMID:7670657 11. Louis DN, Scheithauer B W, Budka H, Von Deimling A, Kep es JJ: Meningiomas, in Kleihues P, Cavenee WK (eds): World Health Organization Classif ication of Tumours. Pathology and Genetics of Tumours of the Nervous System. Lyon: IARC Press, 2000,176 184. 12. Mawrin C, Perry A. Pathological classif ication and molecular genetics of meningiomas. J Neurooncol 2010
379391. PMID:20809251 13. McCarthy BJ, Davis FG, Freels S et al. Factors associated with survival in p atients with meningioma. J Neurosurg 1998
831839. PMID:9576250 14. Nakasu S, Li DH, Okabe H, et al. Signif icance of MIB-1 staining indices in meningiomas: comp arison of two counting methods. Am J Surg Pathol 2001
47278. PMID:11257621 15. Ng HK, Poon WS, Goh K, e