AI Summary & Key Takeaways
AI InsightThis effect was seen only if the multi-dose application of the dex.Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, hasrevealed positive significant changes in the sciatic nerve injury through analgesic effect of it.
📌 3 Key Takeaways
Abstract
Object: Local applications of Dexketoprofen trometamol (dex) have been shown to increasein the sciatic nerve functional tests following the nerve injuries. The aim of the current studywas to compare the efficacy of dex application for 1 and 5 days following nerve injury ratmodel. Possible effects of dex were checked by means of the Sciatic Function Index (SFI),Withdrawal of the Reflex Leg (WRL), number of axons, axon diameter, and nerve diameters.Material Methods: The animal crushed model was done through Aesculap -Yasargilaneurysm method on Wistar albino (N=21) right sciatic nerves. In order to achieve desiredpurpose 3 experimental groups were organized: Group 1: control (injured and no drug);Group2: dexketoprofen 1 days (injured and single dose of drug); Group3: dexketoprofen 5days (injured and single dose of 5 times drug applications). Injections were done through thetissue expander's injection port with a connecting tube directed at the crush-injured site.Functional recovery of the sciatic nerves was evaluated with the improvement in the SFIvalues. Additionally, recovery of sensory function was assessed through WRL results andhistopathological examination was performed 6 week following the injury.Results: At the end of the experimental periods there was no significant differences werefound between the experimental group of animals on the bases of the number of axons, axondiameter, and nerve diameter. Moreover, up 30th day of the experimental period ourfunctional test results have shown that there was no difference between the groups. Butfollowing the induction of the injury, the statistical significances were seen on the functionaltests. This effect was seen only if the multi-dose application of the dex.Conclusions: This study suggests that; dexketoprofen trometamol of 5 consecutive days, hasrevealed positive significant changes in the sciatic nerve injury through analgesic effect of it.
Özet
Amaç: Bu çalışmanın amacı, sıçanlarda siyatik sinir ezilme yaralanmalarında lokal olarakuygulanan deksketoprofen'in etkilerini karşılaştırmaktır. Bunun için sıçan modelinde yaralısiyatik sinirlerin Siyatik Fonksiyon Endeksi ( SFI ), Refleks Bacak geri çekilmesi (WRL),akson sayısı, parametreleri üzerinde 1 gün, 5 gün ve kontrol gruplarında akson çapı ve sinirçapı birlikte değerlendirilerek nöronal hasar incelendi.Yöntem ve Gereç: Wistar albino sıçanlar ( 21 hayvan ) kullanıldı. Sağ siyatik sinir birAesculap - Yaşargil anevrizma kullanılarak 10 saniye ezildi ve 10 saniye sonra anevrizmaklibi açıldı. Deney hayvanları Grup 1, Grup 2 ve Grup 3 olarak üç gruba ayrıldı. Duyusalfonksiyonun iyileşmesi WRL ile değerlendirildi . Histo-patolojik inceleme yapıldı.Bulgular: Akson sayısı, akson çapı ve sinir çap bazında gruplar arasında anlamlı fark yoktu.Ama yaralanma indüksiyonundan sonra, istatistiksel olarak anlamlı fonksiyonel testlergörüldü. Bu etki yalnızca çok dozlu Dex uygulamalarında etkili olarak bulundu.Sonuç: Bu çalışma; 5 gün üst üste deksketoprofen trometamol uygulanmasının, analjeziketkisi ile siyatik sinir hasarı üzerinde olumlu önemli etkilerinin olduğunu ortaya çıkarmıştır.