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Journals / Journal of Neurological Sciences (Turkish) / 2014 / Cilt: 31 - Sayı: 2

Gestasyonel Diabet Yavru Sıçanların Dentat Giruslarında Nöronal Yitime Yol Açar

Gestational Diabetes Induces Neuronal Loss in Dentate Gyrus in Rat Offspring

Mohammad Jafar GOLALIPOUR
Soraya GHAFARI
Sakineh Kaboli KAFSHGIRI
Pages
316–324
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The number of granular cells and thickness of layers ofhippocampus in dentate gyrus lateral (DGl) and dentate gyrus media (DGm) were evaluated.Results: In P7, P14, P21, granular cells numbers of DGm were significantly reduced from(107.6±6.2, 131.6±4.6, 143.5±4.0) in controls to(84.96±2.1, 109.8±7.3, 121.05±5.6)(P

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Objective & Hypothesis:Background: This study was conducted to determine the effect of gestational diabetes onneuronal density in the dentate gyrus (DG) subfields of hippocampus in rats offspring.Methods: On day 1 of gestation, 10 dams randomly allocated into two control and diabeticgroups.
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Key Findings & Data:Five animals in diabetic group were received 40 mg/kg/BW of Streptozotocin(intraperitoneally) and control animals were received normal saline.
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Conclusion & Impact:The number of granular cells and thickness of layers ofhippocampus in dentate gyrus lateral (DGl) and dentate gyrus media (DGm) were evaluated.Results: In P7, P14, P21, granular cells numbers of DGm were significantly reduced from(107.6±6.2, 131.6±4.6, 143.5±4.0) in controls to(84.96±2.1, 109.8±7.3, 121.05±5.6)(P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: This study was conducted to determine the effect of gestational diabetes onneuronal density in the dentate gyrus (DG) subfields of hippocampus in rats offspring.Methods: On day 1 of gestation, 10 dams randomly allocated into two control and diabeticgroups. Five animals in diabetic group were received 40 mg/kg/BW of Streptozotocin(intraperitoneally) and control animals were received normal saline. Six offsprings of eachgestational diabetes mellitus and controls were randomly selected at the day 7, 14 and 21.Infants were scarified and coronal sections were taken from the right dorsal hippocampus andstained with cresyl violet. The number of granular cells and thickness of layers ofhippocampus in dentate gyrus lateral (DGl) and dentate gyrus media (DGm) were evaluated.Results: In P7, P14, P21, granular cells numbers of DGm were significantly reduced from(107.6±6.2, 131.6±4.6, 143.5±4.0) in controls to(84.96±2.1, 109.8±7.3, 121.05±5.6)(P

Özet

Giriş: Bu çalışma gestasyonel diabetin sıçan yavrularının hipokampuslarındaki dentat girus(DG) alt-alanlarında nöronal yoğunluğa olan etkisini araştırmak üzere kurgulandı.Yöntem: Gebeliğin 1. günü 10 eş gelişigüzel olarak kontrol ve diabetik grup olarak ayrıldılar.Diabetik gruptaki 5 denek periton içine 40mg/Kg/Bw dozunda Streptozotocin, kontrolgrubundaki hayvanlar ise normal tuzlu su aldılar. Hem gestasyonal diabetik gruptan hem dekontrol grubundan 6 yavru 7.,14. ve 21. günlerde gelişigüzel seçildiler. Yavrular sakrifiyeedilerek sağ dorsal hipokampuslarının koroner kesitleri alınadı ve kresil moru ile boyandı.Hipokampus lateral (DGl) ve medial (DGm) dentat girus kalınlıkları ve granüler hücrelerideğerlendirildi.Sonuç: DGm P7, P14 ve P21de granüler hücre sayılarında kontrollere göre sırasıyla belirginbir azalma (107.6±6.2, 131.6±4.6, 143.5±4.0) (84.96±2.1, 109.8±7.3, 121.05±5.6)(P

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Cite This Article

GOLALIPOUR, M. J., GHAFARI, S., KAFSHGIRI, S. K. (2022). Gestasyonel Diabet Yavru Sıçanların Dentat Giruslarında Nöronal Yitime Yol Açar. Journal of Neurological Sciences (Turkish), Cilt: 31 - Sayı: 2, 316–324. https://ajindex.com/articles/564998

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