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Journals / Journal of Neurological Sciences (Turkish) / 2014 / Cilt: 31 - Sayı: 4

Deneysel Subaraknoid Kanamanın Yol Açtığı Vasküler ve Hemodinamik Değişiklikler

Vascular and Hemodynamic Changes Induced by Experimental Subarachnoid Hemorrhage

Ender KORFALI
Murat ULUTAŞ
Pages
726–735
Publication Date
2022-10-19
DOI
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Histopathological assessments wereperformed in controls (n=7) as well as in rats surviving for 72 hours.Results: An abrupt reduction of 63.2% ± 10% was observed in CBF, followed by 38.1 ± 13%and 29.1 ± 11% lower values as compared to baseline at 35 and 60 minutes, respectively (p

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Objective & Hypothesis:Objective: In this experimental subarachnoid hemorrhage (SAH) model, pathophysiologicalprocesses that accompany acute vasospasm, morphological changes in the basilar artery, andthe effect of altered cerebral blood flow (CBF) on mortality were examined.Material and Methods: In the hemorrhage group of rats (n=51), experimental subarachnoidhemorrhage was induced and mean arterial pressure (MAP) and cerebral blood flow (CBF)measurements were performed following bleeding.
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Key Findings & Data:Objective: In this experimental subarachnoid hemorrhage (SAH) model, pathophysiologicalprocesses that accompany acute vasospasm, morphological changes in the basilar artery, andthe effect of altered cerebral blood flow (CBF) on mortality were examined.Material and Methods: In the hemorrhage group of rats (n=51), experimental subarachnoidhemorrhage was induced and mean arterial pressure (MAP) and cerebral blood flow (CBF)measurements were performed following bleeding.
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Conclusion & Impact:Histopathological assessments wereperformed in controls (n=7) as well as in rats surviving for 72 hours.Results: An abrupt reduction of 63.2% ± 10% was observed in CBF, followed by 38.1 ± 13%and 29.1 ± 11% lower values as compared to baseline at 35 and 60 minutes, respectively (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In this experimental subarachnoid hemorrhage (SAH) model, pathophysiologicalprocesses that accompany acute vasospasm, morphological changes in the basilar artery, andthe effect of altered cerebral blood flow (CBF) on mortality were examined.Material and Methods: In the hemorrhage group of rats (n=51), experimental subarachnoidhemorrhage was induced and mean arterial pressure (MAP) and cerebral blood flow (CBF)measurements were performed following bleeding. Histopathological assessments wereperformed in controls (n=7) as well as in rats surviving for 72 hours.Results: An abrupt reduction of 63.2% ± 10% was observed in CBF, followed by 38.1 ± 13%and 29.1 ± 11% lower values as compared to baseline at 35 and 60 minutes, respectively (p

Özet

Amaç: Çalışmamızda deneysel subaraknoid kanama (SAK) modelinde, akut vazospazmaeşlik eden patofizyolojik süreçler, baziler arterdeki morfolojik değişiklikler ve serebral kanakımı (SKA) değişikliğinin mortaliteye etkisi incelenmiştir.Yöntem ve Gereç: Kanama grubundaki sıçanlarda (n=51) deneysel subaraknoid kanamaoluşturuldu ve bunlarda kanama sonrasında ortalama arter basıncı (OAB) ve serebral kanakımı ölçümleri yapıldı. Kontrol grubunda (n=7) ve 72 saatten uzun yaşayan kanamagrubundaki sıçanlarda histopatolojik değerlendirmeler yapıldı.Bulgular: SKA'daki %63.2±10 oranındaki ani düşme, 35. dakikada bazal değerin %38.1±13ve 60. dakikada %29.1±11 altında seyretti (p

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Cite This Article

KORFALI, E., ULUTAŞ, M. (2022). Deneysel Subaraknoid Kanamanın Yol Açtığı Vasküler ve Hemodinamik Değişiklikler. Journal of Neurological Sciences (Turkish), Cilt: 31 - Sayı: 4, 726–735. https://ajindex.com/articles/564995

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