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Journals / Journal of Neurological Sciences (Turkish) / 2015 / Cilt: 32 - Sayı: 2

Vernicke Ansefalopatisi ve Santral Pontin Myelinozis: Alkoliklerde Gözden Kaçabilen Bir Tanı

Wernicke Encephalopathy and Central Pontine Myelinolysis: An Underdiagnosed Combination in Alcoholics

Amparo LOPEZ BERNUS
Alvaro GALINDO MUNOZ
Maria Teresa BARROSO MOREIRO
Virginia TIRADO VELASCO
Adela CARPIO PEREZ
Moncef BELHASSEN GARCIA
Pages
418–423
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thesymptoms gradually improved after 1 month with only conservative treatment, and the 4month-follow-up MRI showed complete resolution of the pontine lesions.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Wernicke´s encephalopathy (WE) and central pontine myelinolysis (CPM) are two neurologicdiseases associated with several conditions.
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Key Findings & Data:In patients with chronic alcoholism thecombination of WE and CPM is rare and little is known about its clinical picture and theradiological changes.
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Conclusion & Impact:Thesymptoms gradually improved after 1 month with only conservative treatment, and the 4month-follow-up MRI showed complete resolution of the pontine lesions.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Wernicke´s encephalopathy (WE) and central pontine myelinolysis (CPM) are two neurologicdiseases associated with several conditions. In patients with chronic alcoholism thecombination of WE and CPM is rare and little is known about its clinical picture and theradiological changes. We report a chronic alcoholic patient, who had classic clinical featuresof WE with additional features of CPM without hyponatremia during alcohol withdrawal. Thesymptoms gradually improved after 1 month with only conservative treatment, and the 4month-follow-up MRI showed complete resolution of the pontine lesions.

Özet

Vernicke Ansefalopatisi (VE) ve santral pontin myelinozis (SPM) birkaç durumda görülen ikiayrı nörolojik tanıdır. Kronik alkolik hastalarda VE ve SPMnin birlikte görülmesi ender birdurumdur. Bu klinik tablo ve radyolojik değişikliklerle ilgili az şey bilinmektedir. BuradaVEnin klasik bulgularıyla birlikte ek olarak hiponatremisi olmadığı halde SPMnin bulgularıolan alkol yoksunluğu halinde kronik alkolik bir olgu sunuyoruz. Tutucu tedaviylesemptomlar bir ay içerisinde tedricen düzelmiştir. Takibin dördüncü ayında elde olunanMRGde pontin lezyonların tamamen kaybolduğu görülmektedir.

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Cite This Article

BERNUS, A. L., MUNOZ, A. G., MOREIRO, M. T. B., VELASCO, V. T., PEREZ, A. C., GARCIA, M. B. (2022). Vernicke Ansefalopatisi ve Santral Pontin Myelinozis: Alkoliklerde Gözden Kaçabilen Bir Tanı. Journal of Neurological Sciences (Turkish), Cilt: 32 - Sayı: 2, 418–423. https://ajindex.com/articles/564943

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References (13)

  1. Antunez E, Estruch R, Cardenal C, Nicolas JM, Fernandez-Sola J, Urbano-Marquez A. Usef ulness of CT and MR imaging in the diagnosis of acute Wernicke's encep halop athy. AJR American j ournal of roentgenology. 1998;171(4):1131–1137. doi:10.2214/aj r.171.4.9763009
  2. Brown WD. Osmotic demyelination disorders: central p ontine and extrap ontine myelinolysis. Current op inion in neurology. 2000;13(6):691–697
  3. Chason JL, Landers J W, GONZALEZ JE. CENTRAL PONTINE MYELINOLYSIS. Journal of neurology, neurosurgery, and psychiatry. 1964;27:317–325
  4. Droogan AG, Mirakhur M, Allen I V, Kirk J, Nicholls DP. Central p ontine myelinolysis without hyp onatraemia. The Ulster medical j ournal. 1992;61(1):98–101
  5. Esf orzado N, Poch E, Cases A, Cardenal C, Lóp ez- Pedret J, Revert L. Central p ontine myelinolysis secondary to f requent and rap id shif ts in p lasma glucose in a diabetic haemodialysis p atient. Nep hrology, dialysis, transp lantation: off icial p ublication of the Europ ean Dialysis and Transp lant Association - Europ ean Renal Association. 1993;8(7):644–646
  6. Gocht A, Colmant HJ. Central p ontine and extrap ontine myelinolysis: a rep ort of 58 cases. Clinical neurop athology. 1987;6(6):262–270
  7. Jacob S, Gup ta H, Nikolic D, Gundogdu B, Ong S. Central p ontine and extrap ontine myelinolysis: the great masquerader-an autopsy case rep ort. Case Rep Neurol Med. 2014;2014(2):745347–5. doi:10.1155/2014/ 745347
  8. Kishimoto Y, Ikeda K, Murata K, Kawabe K, Hirayama T, Iwasaki Y. Rap id develop ment of central p ontine myelinolysis af ter recovery f rom Wernicke encep halop athy: a non-alcoholic case without hyp onatremia. Internal medicine (Tokyo, Jap an). 2012;51(12):1599–1603
  9. Kleinschmidt-Demasters BK, Roj iani AM, Filley CM. Central and extrap ontine myelinolysis: then.and now. Journal of neurop athology and exp erimental neurology. 2006;65(1):1–11
  10. Korn-Lubetzki I, Virozub Y, Orbach H. Central p ontine myelinolysis af ter alcohol withdrawal. The Israel Medical Association j ournal: IMAJ. 2002;4(8):656
  11. Manzanares W, Hardy G. Thiamine supp lementation in the critically ill. Current op inion in clinical nutrition and metabolic care. 2011;14(6):610–617. doi:10.1097/MCO.0b013e32834b8911
  12. Martin RJ. Central p ontine and extrap ontine myelinolysis: the osmotic demyelination syndromes. Journal of neurology, neurosurgery, and psychiatry. 2004;75 Supp l 3(supp l_3):iii22–8. doi:10.1136/j nnp.2004.045906
  13. McComb RD,