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Journals / Journal of Neurological Sciences (Turkish) / 2015 / Cilt: 32 - Sayı: 4

Melatoninin Deneysel Subaraknoid Kanama Sonrası Gelişen Vazospazmda Paradoksal Morfometrik ve Antioksidatif Etkisi

Paradoxical Morphometric and Antioxidative Effects of Melatonin on Vasospasm in Experimental Subarachnoid Hemorrhage

Mehmet ALPTEKİN
Sırma GEYİK
İbrahim ERKUTLU
Murat GEYİK
Abdulvahap GÖK
İnan GEZGİN
Pages
756–766
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In group IV area of lumen (AL) was found to be increased suggesting vasodilation (p

📌 3 Key Takeaways

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Objective & Hypothesis:The purpose of this study is to investigate the histopathologic, biochemical and morphometric effects of melatonin on basilar artery and oxidative balances during subacute vasospasm following a subarachnoid hemorrhage (SAH).
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Key Findings & Data:Rats were divided randomly into 4 groups, six rats in each group: no SAH (group Icontrol), only SAH (group II-control), SAH plus melatonin 5mg/kg (group III), and SAH plus melatonin 10mg/kg (group IV).
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Conclusion & Impact:In group IV area of lumen (AL) was found to be increased suggesting vasodilation (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The purpose of this study is to investigate the histopathologic, biochemical and morphometric effects of melatonin on basilar artery and oxidative balances during subacute vasospasm following a subarachnoid hemorrhage (SAH). Twenty-four male Wistar rats were used in the study. Rats were divided randomly into 4 groups, six rats in each group: no SAH (group Icontrol), only SAH (group II-control), SAH plus melatonin 5mg/kg (group III), and SAH plus melatonin 10mg/kg (group IV). Melatonin was administered intraperitoneally just after SAH and repeated at 24th hour after as a second dose. Animals were sacrificed 9 days after SAH, and the basilar artery was harvested for morphometric and histopathologic studies. Biochemical assays also were performed in terms of oxidant and antioxidant balance. In group IV area of lumen (AL) was found to be increased suggesting vasodilation (p

Özet

Bu çalışmanın amacı melatoninin SAK sonrası gelişen subakut vazospazmda oksidatif dengelere ve baziler arterin histopatolojik, biyokimyasal ve morfometrik sonuçlarına etkilerini incelemektir. Bu çalışmada 24 adet erkek Wistar sıçanı kullanılmıştır. Sıçanlar rastgele 4 gruba ayrılmıştır. Her grupta 6 denek kullanılmıştır: SAK olmayan ( Grup 1 - kontrol), yalnızca SAK (Grup 2 - kontrol), SAK + melatonin 5 mg/kg(Grup 3) ve SAK + Melatonin 10 mg/kg(Grup 4) Melatonin hemen SAK sonrası ve 2. Doz olarak 24 saat sonra intraperitoneal olarak uygulandı. Denekler SAK sonrası 9. günde sakrifiye edilerek baziller arterden morfometrik ve histopatolojik çalışmalar için örnek alındı. Aynı zamanda oksidan ve antioksidan denge açısından biyokimyasal analizler yapıldı. Grup 4' de lümen alanının kontrol gruplarına nisbeten vazodilatasyonu düşündürecek tarzda arttığı gözlendi.(p

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Cite This Article

ALPTEKİN, M., GEYİK, S., ERKUTLU, İ., GEYİK, M., GÖK, A., GEZGİN, İ. (2022). Melatoninin Deneysel Subaraknoid Kanama Sonrası Gelişen Vazospazmda Paradoksal Morfometrik ve Antioksidatif Etkisi. Journal of Neurological Sciences (Turkish), Cilt: 32 - Sayı: 4, 756–766. https://ajindex.com/articles/564919

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