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Journals / Journal of Istanbul University Faculty of Dentistry / 2016 / Cilt: 50 - Sayı: 2

Tavşanlarda Çift rombositten Zengin Plazma Uygulaması Sonrasında Osteokalsin ve Osteonektin Ekspresyonu

OSTEOCALCIN AND OSTEONECTIN EXPRESSION AFTER DOUBLEAPPLICATION OF PLATELET—RICH PLASMA IN RABBITS

Burcu ÖZDEMİR
Bülent KURTİŞ
Gülay TÜTER
Benay YILDIRIM
Burcu ŞENGÜVEN
Gönen ÖZCAN
Pages
1–9
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The three groupstreated with ,B—TCP showed higher percentage of ONthan those treated without fl-TCP @

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Platelet-rich plasma (PRP) is novel methodfor transferring autogenous growth factors to thewound area.
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Key Findings & Data:The aim of this study was to evaluate theeflicacy of double-application of PRP (DA-PRP) onbone healing in rabbit cranial defects by examiningosteonectin (ON) and osteocalcin (OC) expression.Materials andMethods: Twenty-eight rabbits, each with twosurgically prepared calvarial bone defects, were includedin this study and divided into six groups: The defects(N=56) were treated With either single-application ofPRP (SA-PRP) (n=10), combination ofSA-PRP and betatricalciumphosphate(SA-PRP+/3-TCP) (nZIO), only DAPRP(n=8), both DA-PRP and beta-tricalciumphosphate(DA-PRP+,B-TCP) (n=8), only(fl-TCP) (n=10), or controls (n=10).
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Conclusion & Impact:The three groupstreated with ,B—TCP showed higher percentage of ONthan those treated without fl-TCP @
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Platelet-rich plasma (PRP) is novel methodfor transferring autogenous growth factors to thewound area. The aim of this study was to evaluate theeflicacy of double-application of PRP (DA-PRP) onbone healing in rabbit cranial defects by examiningosteonectin (ON) and osteocalcin (OC) expression.Materials andMethods: Twenty-eight rabbits, each with twosurgically prepared calvarial bone defects, were includedin this study and divided into six groups: The defects(N=56) were treated With either single-application ofPRP (SA-PRP) (n=10), combination ofSA-PRP and betatricalciumphosphate(SA-PRP+/3-TCP) (nZIO), only DAPRP(n=8), both DA-PRP and beta-tricalciumphosphate(DA-PRP+,B-TCP) (n=8), only(fl-TCP) (n=10), or controls (n=10). The animals weresacrificed at 30th day postoperatively and samples wereimmunohistochemicallyexaminedforONandOCexpressions.Results: It was determined that DA-PRP did notsignificantly improve the ON and OC percentagesachieved by SA-PRP or the controls. The three groupstreated with ,B—TCP showed higher percentage of ONthan those treated without fl-TCP @

Özet

Amaç: Trombositten--zengin plazma (TZP) otojen büyümefaktörlerini yara bölgesine taşıyan bir yöntemdir: Buaraştırmada çift ZP uygulamasının (Ç--TZP) tavşankraniyal defektlerinde kemik iyileşmesi üzerine etkileriniosteonektin (ON) ve osteokalsin (OC) ekspresyonlarınındeğerlendirilerek incelenmesi amaçlandı.Gereç ve Yöntem: Her birinde cerrahi olarakoluşturulmuş iki adet kraniyal defekt olan yirmi sekiztavşan çalışmaya dâhil edildi. Defektler (n=56) tek TZPuygulamasıyla (T-TZP)(n=10), tek TZP uygulaması ve betatrikalsiyumfosfatkombinasyonuyla (T-TZP+fl-TCP)(n=10),Ç--TZP ile (n=8) veya Ç--TZP ve ,B-TCP kombinasyonuyla(Ç--IZP+ ,B-TCP) (n=8) tedavi edilenler ve control grubu(n=10) olmak üzere altı gruba ayrıldı. Deney hayvanları 30.Günde sakrifiye edildiler ve örnekler immunohistokimyasalolarak ON ve OC için incelendi.Bulgular: Ç--TZP uygulamasının T-TZP ya da kontrolgruplarında elde edilen ON ve OC yüzdelerini anlamlıolarak arttırmadığı görüldü. fi-TCP uygulanan üç grupta,fl-TCP uygulanmayan gruplara göre daha yüksek ONyüzdeleri saptandı @

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Cite This Article

ÖZDEMİR, B., KURTİŞ, B., TÜTER, G., YILDIRIM, B., ŞENGÜVEN, B., ÖZCAN, G. (2022). Tavşanlarda Çift rombositten Zengin Plazma Uygulaması Sonrasında Osteokalsin ve Osteonektin Ekspresyonu. Journal of Istanbul University Faculty of Dentistry, Cilt: 50 - Sayı: 2, 1–9. https://ajindex.com/articles/563821

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