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Journals / Journal of Istanbul University Faculty of Dentistry / 2016 / Cilt: 50 - Sayı: 1

Tavşanlarda Çift Trombosittrn Zengin Plazma Uygulaması Sonrasında Osteokalsin ve Osteonektin Ekspresyonu

Osteocalcın and osteonectın expressıon after double-applIcatIon of platelet-rIch plazma In rabbits

Gülay TÜTER
Benay YILDIRIM
Burcu ÖZDEMİR
Burcu ŞENGÜVEN
Gönen ÖZCAN
Bülent KURTİŞ
Pages
1–9
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The three groups treated with ?-TCP showed a higher percentage of ON than those treated without ?-TCP (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Platelet-rich plasma (PRP) is a novel method for transferring autogenous growth factors to the wound area.
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Key Findings & Data:Materials and Methods: Twenty-eight rabbits, each with two surgically prepared calvarial bone defects, were included in this study and divided into six groups: The defects (N=56) were treated with either a single-application of PRP (SA-PRP) (n=10), a combination of SA-PRP and betatricalciumphosphate (SA-PRP+?-TCP) (n=10), only DAPRP (n=8), both DA-PRP and beta-tricalciumphosphate (DA-PRP+?-TCP) (n=8), only beta-tricalciumphosphate (?-TCP) (n=10), or controls (n=10).
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Conclusion & Impact:The three groups treated with ?-TCP showed a higher percentage of ON than those treated without ?-TCP (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Platelet-rich plasma (PRP) is a novel method for transferring autogenous growth factors to the wound area. The aim of this study was to evaluate the efficacy of double-application of PRP (DA-PRP) on bone healing in rabbit cranial defects by examining osteonectin (ON) and osteocalcin (OC) expression. Materials and Methods: Twenty-eight rabbits, each with two surgically prepared calvarial bone defects, were included in this study and divided into six groups: The defects (N=56) were treated with either a single-application of PRP (SA-PRP) (n=10), a combination of SA-PRP and betatricalciumphosphate (SA-PRP+?-TCP) (n=10), only DAPRP (n=8), both DA-PRP and beta-tricalciumphosphate (DA-PRP+?-TCP) (n=8), only beta-tricalciumphosphate (?-TCP) (n=10), or controls (n=10). The animals were sacrificed at 30th day postoperatively and samples were immunohistochemically examined for ON and OC expressions.Results: It was determined that DA-PRP did not significantly improve the ON and OC percentages achieved by SA-PRP or the controls. The three groups treated with ?-TCP showed a higher percentage of ON than those treated without ?-TCP (p

Özet

Amaç: Trombositten-zengin plazma (TZP) otojen büyüme faktörlerini yara bölgesine taşıyan bir yöntemdir. Bu araştırmada çift TZP uygulamasının (Ç-TZP) tavşan kraniyal defektlerinde kemik iyileşmesi üzerine etkilerini osteonektin (ON) ve osteokalsin (OC) ekspresyonlarının değerlendirilerek incelenmesi amaçlandı.Gereç ve Yöntem: Her birinde cerrahi olarak oluşturulmuş iki adet kraniyal defekt olan yirmi sekiz tavşan çalışmaya dâhil edildi. Defektler (n=56) tek TZP uygulamasıyla (T-TZP)(n=10), tek TZP uygulaması ve betatrikalsiyumfosfat kombinasyonuyla (T-TZP+?-TCP)(n=10), Ç-TZP ile (n=8) veya Ç-TZP ve ?-TCP kombinasyonuyla (Ç-TZP+ ?-TCP) (n=8) tedavi edilenler ve control grubu (n=10) olmak üzere altı gruba ayrıldı. Deney hayvanları 30. Günde sakrifiye edildiler ve örnekler immunohistokimyasal olarak ON ve OC için incelendi. Bulgular: Ç-TZP uygulamasının T-TZP ya da kontrol gruplarında elde edilen ON ve OC yüzdelerini anlamlı olarak arttırmadığı görüldü. ?-TCP uygulanan üç grupta, ?-TCP uygulanmayan gruplara göre daha yüksek ON yüzdeleri saptandı (p

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Cite This Article

TÜTER, G., YILDIRIM, B., ÖZDEMİR, B., ŞENGÜVEN, B., ÖZCAN, G., KURTİŞ, B. (2022). Tavşanlarda Çift Trombosittrn Zengin Plazma Uygulaması Sonrasında Osteokalsin ve Osteonektin Ekspresyonu. Journal of Istanbul University Faculty of Dentistry, Cilt: 50 - Sayı: 1, 1–9. https://ajindex.com/articles/563798

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