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Journals / Journal of Istanbul University Faculty of Dentistry / 2017 / Cilt: 51 - Sayı: 1

LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS

Gingivitisin Genç ve Orta Yaşlı Bireylerde Dişeti Oluğu Sıvısı LL-37 Seviyelerine Etkisi

Necil KÜTÜKCÜLER
Harika ATMACA
Gül ATİLLA
Gülnur EMİNGİL
Oya TÜRKOĞLU
Gülnihal EREN
Pages
15–21
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity.
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Key Findings & Data:The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues.Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study.
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Conclusion & Impact:However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: LL-37 is an antimicrobial peptide which plays an important role in the innate immunity. The aim of this study was to investigate the LL-37 levels in the gingival crevicular fluid (GCF) of middle-aged and young adults who have either gingivitis or healthy periodontal tissues.Materials and Methods: Forty middle-aged adults (20 healthy controls and 20 with gingivitis) and 41 younger adults (20 healthy controls and 21 with gingivitis) were included in the present study. Probing depth, clinical attachment level, plaque index, and papilla bleeding index were recorded. LL-37 levels in the GCF were analyzed by enzyme-linked immunosorbent assay. Results: No significant differences were observed in the GCF LL-37 levels between young healthy and middleaged healthy subjects. Also, there were no significant differences in GCF LL-37 levels between young and middle-aged gingivitis subjects. However, gingivitis groups had significantly higher GCF LL-37 levels than healthy groups (p

Özet

Amaç: Bir antimikrobiyal peptid olan LL-37 doğal immunitede önemli rol oynar. Bu çalışmanın amacı gingivitis tanısı almış ya da sağlıklı dişetlerine sahip olan genç ve orta yaşlı erişkin hastalarda dişeti oluk sıvısındaki (DOS) LL-37 seviyelerini incelemektir.Gereç ve Yöntem: Bu çalışmaya 40 orta yaşlı erişkin (20 sağlıklı kontrol ve 20 gingivitisli) ve 41 genç erişkin (20 sağlıklı kontrol ve 21 gingivitisli) hasta dâhil edilmiştir. Sondalama derinliği, klinik ataşman seviyesi, plak indeksi ve papilla kanama indeksi değerleri kaydedilmiştir. DOS LL-37 seviyeleri enzim bağlı immunoabsorbent testi ile ölçülmüştür.Bulgular: Dişetleri sağlıklı olan genç ve orta yaşlı bireylerin LL-37 seviyeleri arasında bir farklılık izlenmedi. Benzer şekilde gingivitisli genç ve orta yaşlı erişkinlerde DOS LL-37 seviyeleri arasında da fark gözlenmedi. Her iki gingivitis grubu sağlıklı kontrol gruplarına göre daha yüksek DOS LL-37 seviyesine sahipti (p

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Cite This Article

KÜTÜKCÜLER, N., ATMACA, H., ATİLLA, G., EMİNGİL, G., TÜRKOĞLU, O., EREN, G. (2022). LEVELS OF LL-37 ANTIMICROBIAL PEPTIDE IN THE GINGIVAL CREVICULAR FLUID OF YOUNG AND MIDDLE-AGED SUBJECTS WITH OR WITHOUT GINGIVITIS. Journal of Istanbul University Faculty of Dentistry, Cilt: 51 - Sayı: 1, 15–21. https://ajindex.com/articles/563792

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