Journals / Journal of critical and intensive care (Online) / 2020 / Cilt: 11 - Sayı: 3

Clinical Diagnosis and Ancillary Tests in Brain Death: Effects on The Organ Donation Process

Pages
72–77
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No significant difference was found between Groups I and II in terms of organ donation consent.Themost common reasons for refusal of organ donation rejection was concern about disruption of body integrity(31.1%), not believing in brain death (24.6%), religious reasons (11.5%) and disagreement of family members(6.6%), respectively.Conclusion: According to the results of our study, the use of the ancillary confirmatory test in the diagnosis ofbrain death is recommended because it shortens the duration of the diagnosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Demographic data of patients diagnosed as brain dead at our intensive care unit were evaluatedalong with the methods used to diagnose brain death, their effects on the timing of the diagnosis, and theireffects on each family’s donation decision as well as the reasons for donation refusal.Methods:In this single-center study, data of patients diagnosed with brain death at the tertiary intensive careunit (ICU), between January 2012 and December 2018 were evaluated retrospectively.Results: The data of a total of 110 patients diagnosed in ICU were evaluated.
📊
Key Findings & Data:The BD diagnosis time wasmedian (min-max) 24.5 hours (12-48) in the clinical evaluation group (Group I) and 20.5 hours (7-28) inthe ancillary confirmatory test group (Group II).
💡
Conclusion & Impact:No significant difference was found between Groups I and II in terms of organ donation consent.Themost common reasons for refusal of organ donation rejection was concern about disruption of body integrity(31.1%), not believing in brain death (24.6%), religious reasons (11.5%) and disagreement of family members(6.6%), respectively.Conclusion: According to the results of our study, the use of the ancillary confirmatory test in the diagnosis ofbrain death is recommended because it shortens the duration of the diagnosis.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Demographic data of patients diagnosed as brain dead at our intensive care unit were evaluatedalong with the methods used to diagnose brain death, their effects on the timing of the diagnosis, and theireffects on each family’s donation decision as well as the reasons for donation refusal.Methods:In this single-center study, data of patients diagnosed with brain death at the tertiary intensive careunit (ICU), between January 2012 and December 2018 were evaluated retrospectively.Results: The data of a total of 110 patients diagnosed in ICU were evaluated. The BD diagnosis time wasmedian (min-max) 24.5 hours (12-48) in the clinical evaluation group (Group I) and 20.5 hours (7-28) inthe ancillary confirmatory test group (Group II). In Group I, the diagnostic time was significantly shorterin comparison with group II. Family organ donation consent could not be obtained in 61 (55.5%) of 110cases. No significant difference was found between Groups I and II in terms of organ donation consent.Themost common reasons for refusal of organ donation rejection was concern about disruption of body integrity(31.1%), not believing in brain death (24.6%), religious reasons (11.5%) and disagreement of family members(6.6%), respectively.Conclusion: According to the results of our study, the use of the ancillary confirmatory test in the diagnosis ofbrain death is recommended because it shortens the duration of the diagnosis. According to the results of ourstudy, the method of diagnosis did not affect family decisions.

🔖

Cite This Article

ZINCIRCIOGLU, C., SARITAS, A., SENOGLU, N., GULDOGAN, I. K., UZUN, U., YILDIRAN, A. A., ROLLAS, K., YILDIRIM, I., CINLET, B. A. (2022). Clinical Diagnosis and Ancillary Tests in Brain Death: Effects on The Organ Donation Process. Journal of critical and intensive care (Online), Cilt: 11 - Sayı: 3, 72–77. https://ajindex.com/articles/562302

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Westphal GA, Garcia VD, Souza RL, et al. Guidelines for the assessment and acceptance of potential brain-dead organ donors. Rev Bras Ter Intensiva 2016
  2. 220–55. [CrossRef] 2. Wijdicks EF, Varelas PN, Gronseth GS, et al. Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010
  3. 1911–8. [CrossRef] 3. Gardiner D, Shemie S, Manara A, et al. International perspective on the diagnosis of death. Br J Anaesth 2012
  4. i14–28. [CrossRef] 4. Citerio G, Crippa IA, Bronco A, et al. Variability in brain death determination in Europe: looking for a solution. Neurocrit Care 2014
  5. 376–82. [CrossRef] 5. Escudero D, Valentín M O, Escalante JL, et al. Intensive care practices in brain death diagnosis and organ donation. Anaesthesia 2015
  6. 1130–9. [CrossRef] 6. Organ ve doku alınması, saklanması, aşılanması ve nakli hakkında kanun. Kanun numarası 6514. Resmi Gazete 18.01.2014 - 28886. https://www.resmigazete.gov.tr/eskiler/2014/01/20140118-1.htm 7. Citerio G, Cypel M, Dobb GJ, et al. Organ donation in adults: a critical care perspective. Intensive Care Med 2016
  7. 305–15. [CrossRef] 8. Maciel CB, Greer DM. ICU Management of the Potential Organ Donor: State of the Art. Curr Neurol Neurosci Rep 2016
  8. [CrossRef] 9. Busl KM, Greer DM. Pitfalls in the diagnosis of brain death. Neurocrit Care 2009
  9. 276–87. [CrossRef] 10. De Jesus Correia C, Armstrong Jr, Carvalho PO, et al. Hypertonic saline solution reduces microcirculatory dysfunction and inflammation in a rat model of brain death. Shock 2019
  10. 495–501. [CrossRef] 11. Westphal GA, Slaviero TA, Montemezzo A, et al. The effect of brain death protocol duration on potential donor losses due to cardiac arrest. Clin Transplant 2016
  11. 1411–6. [CrossRef] 12. Lustbader D, O’Hara D, Wijdicks EF, et al. Second brain death examination may negatively affect organ donation. Neurology 2011
  12. 119–24 [CrossRef] 13. Resnick S, Seamon MJ, Holena D, et al. Early declaration of death by neurologic criteria results in greater organ donor potential. J Surg Res 2017
  13. 29–34. [CrossRef] 14. Soldatos T, Karakitsos D, Wachtel M, et al. The Value of Transcranial Doppler Sonography With a Transorbital Approach in the Confirmation of Cerebral Circulatory Arrest. Transplant Proc 2010
  14. 1502–6. [CrossRef] 15. Irving MJ, Tong A, Jan S, et al. Factors that influence the decision to be an organ donor: A systematic review of the qual