Journals / Journal of Clinical and Experimental Investigations / 2011 / Cilt: 2 - Sayı: 4

Akut pankreatit hastalarında ortalama trombosit hacmi

Mean platelet volume in patients with acute pancreatitis

Pages
362–365
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Platelet and MPV were correlated with serum CRP levels in correlation analysis (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Platelet contributed tissue damage and inflammations have been of increased interest.
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Key Findings & Data:Materials and methods: The study group consisted of 30 patients with AP and 30 control subjects who were matched for age, gender, body mass index (BMI).
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Conclusion & Impact:Platelet and MPV were correlated with serum CRP levels in correlation analysis (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Platelet contributed tissue damage and inflammations have been of increased interest. It was previously suggested that platelets have an important role in patients with acute pancreatitis (AP). We aimed to assess the mean platelet volume (MPV) which is described as an indicator of platelet activation and platelet count in patients with AP. Materials and methods: The study group consisted of 30 patients with AP and 30 control subjects who were matched for age, gender, body mass index (BMI). MPV values and platelet counts were measured on admission. Results: Mean platelet volume was significantly higher among patients with AP when compared with control group (8.82±1.33 vs. 7.94±0.54 fL respectively; p < 0.01). Platelet count was significantly lower among AP patients when compared with control group (223.0±46.2 vs. 295.3±58.9 ×109/L respectively; p < 0.001). The level of CRP was significantly higher in patients with AP compared with control group. Platelet and MPV were correlated with serum CRP levels in correlation analysis (p

Özet

Amaç: Trombosit ile ilgili doku hasarı ve inflamasyon son zamanlarda ilgi çeken bir konudur. Daha önce de belirtildiği üzere, akut pankreatitli (AP) hastalarda trombosit önemli rol oynamaktadır. Bizim amacımız, AP hastalarda trombosit aktivasyonu ve trombosit sayısının belirteci olarak bildirilen MPV’yi araştırmaktır. Gereç ve yöntem: Çalışma grubu 30 AP hastası ve 30 kontrol hastasından ibaret olup yaş, cinsiyet ve BMI oranları eşleştirilmiştir. MPV değerleri ve trombosit sayıları ölçüldü. Bulgular: Akut pankreatit hastalarında MPV değerleri kontrol grubuyla karşılaştırıldığında ileri derecede yüksek bulunmuştur (8.82±1.33 vs. 7.94±0.54 fL sırayla; p < 0.01). Trombosit sayısı AP hastalarda kontrol grubuyla karşılaştırıldığında anlamlı olarak düşük bulunmuştur (223.0±46.2 vs. 295.3±58.9 ×109/L sırayla; p < 0.001). C-reaktif protein seviyesi ise AP hastalarında kontrol grupla karşılaştırıldığında anlamlı olarak yüksekti. Korelasyon analizinde trombosit ve MPV değerleri serum CRP değerleriyle korele olduğu görüldü (p < 0.01; r = -0.364, r = 0.406 sırayla). AP hastalarında trombosit aktivasyonunu gösteren MPV değerinin yüksek olduğu tespit edilmiştir. Trombosit sayısı ise düşük bulunmuştur. İnflamasyon belirteci olarak bilinen CRP seviyesi ise MPV değeri ve trombosit sayıları ile koreledir. Sonuç: Sonuç olarak, AP hastalarında artmış MPV seviyesi AP’nin teşhisi için bir markır olabilir.

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Cite This Article

BÜYÜKBAŞ, S., YÖNDEN, Z., YILMAZ, N., CAN, Y., ÖZTÜRK, O. H., AYDOĞAN, A., ÖZKAN, O. V. (2022). Akut pankreatit hastalarında ortalama trombosit hacmi. Journal of Clinical and Experimental Investigations, Cilt: 2 - Sayı: 4, 362–365. https://ajindex.com/articles/562013

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