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Journals / Journal of Clinical and Experimental Investigations / 2012 / Cilt: 3 - Sayı: 4

Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis

Eşref AKIL
Mehmet Ufuk ALUÇLU
Sefer VAROL
Hatice YÜKSEL
Adalet ARIKANOĞLU
Yavuz YÜCEL
Mehmet Uğur ÇEVİK
Pages
518–520
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Increased ischemia modified albumin levels, supports the role of oxidative stress in patients with multiple sclerosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Increased levels of free radicals and oxidant molecules and decreased levels of antioxidant molecules have been defined in patients with multiple sclerosis (MS).
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Key Findings & Data:Materials and methods: We compared serum ischemia modified albumin levels and prolidase activity of 42 patients with MS (30 female, 12 male) and 30 age-matched healthy controls (21 female, 9 male).
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Conclusion & Impact:Conclusions: Increased ischemia modified albumin levels, supports the role of oxidative stress in patients with multiple sclerosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Increased levels of free radicals and oxidant molecules and decreased levels of antioxidant molecules have been defined in patients with multiple sclerosis (MS). Ischemia-modified albumin (IMA) levels have been advocated as a biomarker for evaluating the oxidative stress status. The aim of this study was to investigate the relationship between oxidative stress and MS. Materials and methods: We compared serum ischemia modified albumin levels and prolidase activity of 42 patients with MS (30 female, 12 male) and 30 age-matched healthy controls (21 female, 9 male). Results: Ischemia modified albumin levels of MS patients (73,07±26,53 ng/mL) were significantly higher than those of controls (60,18±18,01 ng/mL) (p=0.024). However, there were no significant differences in prolidase levels between patients and healthy controls (p=0.856). Conclusions: Increased ischemia modified albumin levels, supports the role of oxidative stress in patients with multiple sclerosis.

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Cite This Article

AKIL, E., ALUÇLU, M. U., VAROL, S., YÜKSEL, H., ARIKANOĞLU, A., YÜCEL, Y., ÇEVİK, M. U. (2022). Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis. Journal of Clinical and Experimental Investigations, Cilt: 3 - Sayı: 4, 518–520. https://ajindex.com/articles/561941

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References (16)

  1. Gilgun SY, Melamed E, Offen D. The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol 2004; 251(3):261-8
  2. Verma P, Bhattacharya SN, Banerjee BD, et al. Oxidative stress and leukocyte migration inhibition response in cutaneous adverse drug reactions. Indian J Dermatol Venereol Leprol 2012; 78(5):664
  3. Oliveira SR, Kallaur AP, Simao AN, et al. Oxidative stress in multiple sclerosis patients in clinical remission: Association with the expanded disability status scale. J Neurol Sci 2012; 321(1-2):49-53
  4. Syburra C, Passi S. Oxidative stress in patients with multiple sclerosis. Ukr Biokhim Zh 1999; 71(3):112-5
  5. Awadallah SM, Atoum MF, Nimer NA, et al. Ischemia modified albumin: an oxidative stress marker in beta-thalassemia major. Clin Chim Acta 2012; 413(9- 10):907-10
  6. Toy H, Camuzcuoglu H, Camuzcuoglu A, et al. De- creased serum prolidase activity and increased oxida- tive stress in early pregnancy loss. Gynecol Obstet Invest 2010; 69(2):122-7
  7. Uzar E, Tamam Y, Evliyaoglu O, et al. Serum prolidase activity and oxidative status in patients with diabetic neuropathy. Neurol Sci 2012; 33(4):875-80
  8. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med. 2011; 49(2):177-84
  9. Cakir M, Karahan SC, Mentese A, et al. Ischemia- modified albumin levels in children with chronic liver disease. Gut Liver 2012; 6(1):92-7
  10. Duygu F, Koruk ST, Karsen H, et al. Prolidase and oxidative stress in chronic hepatitis C. J Clin Lab Anal 2012;26(4):232-7
  11. Erbagci AB, Araz M, Erbagci A, et al. Serum prolidase activity as a marker of osteoporosis in type 2 diabetes mellitus. Clin Biochem 2002;35(4):263-8
  12. Gecit I, Aslan M, Gunes M, et al. Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer. J Cancer Res Clin Onco 2012;138(5):739-43
  13. Greco A, Minghetti L, Sette G, et al. Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis. Neurology 1999;53(8):1876-9
  14. Karna E, Surazynski A, Palka J. Collagen metabolism disturbances are accompanied by an increase in pro- lidase activity in lung carcinoma planoepitheliale. Int J Exp Pathol 2000;81(5):341-7
  15. Brown WR, Thore CR. Perivascular fibrosis in multiple sclerosis lesions. Brain Pathol 2011;21(3):355
  16. Mohan H, Krumbholz M, Sharma R, et al. Extracellular matrix in multiple scle