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Journals / Journal of Clinical and Experimental Investigations / 2012 / Cilt: 3 - Sayı: 2

İlk trimester serum PAPP-A düzeyleri ve gebelik yaşına göre küçük bebeklerin tahmin edilmesi

First trimester serum PAPP-A levels and the prediction of small-for-gestational age infants

Gökçenur GÖNENÇ
İlkkan DÜNDER
Alin Başgül YİĞİTER
Herman İŞÇİ
Nilgün GÜDÜCÜ
Pages
185–188
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: The low positive predictive value of PAPP- A prevents it from being used as a screening test for the detection of SGA infants.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The aim of this study was to detect the predictive value of PAPP-A in small-for-gestational age (SGA) infants.
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Key Findings & Data:PAPP-A levels less than 5th percentile were considered as predictive of SGA in- fants.
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Conclusion & Impact:Conclusions: The low positive predictive value of PAPP- A prevents it from being used as a screening test for the detection of SGA infants.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: The aim of this study was to detect the predictive value of PAPP-A in small-for-gestational age (SGA) infants. Materials and methods: We retrospectively searched the patient charts of our hospital for first trimester Down syndrome screening test results. PAPP-A levels less than 5th percentile were considered as predictive of SGA in- fants. Results: Low PAPP-A levels were associated with SGA infants, sensitivity was 3,5%, specificity 90%, positive predictive value 1,6% and negative predictive value 95%. Conclusions: The low positive predictive value of PAPP- A prevents it from being used as a screening test for the detection of SGA infants.

Özet

Amaç: Bu çalışmanın amacı ilk trimester serum PAPPA (pregnancy aasociated plasma protein A) seviyelerinin gebelik yaşına göre küçük (GYK) bebekleri tahmin etmede kullanılabilirliğini tespit etmektir. Gereç ve yöntem: Geriye dönük olarak hastanemizin gebe kayıtları incelendi ve ilk trimester Down sendromu tarama testlerinin sonuçları bulundu. PAPP-A seviyeleri 5. persentilin altında kalanlar GYK bebek olarak kabul edildi. Bulgular: Düşük PAPP-A seviyeleri ile GYK bebekler arasında bir ilişki mevcuttur, testin duyarlılığı %3,5, özgüllüğü %90, pozitif kestirim değeri %1,6 ve negatif kestirim değeri %95tir. Sonuç: Testin pozitif kestirim değerinin düşük olması nedeniyle GYK bebekleri tahmin etmek için kullanılması uygun değildir.

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Cite This Article

GÖNENÇ, G., DÜNDER, İ., YİĞİTER, A. B., İŞÇİ, H., GÜDÜCÜ, N. (2022). İlk trimester serum PAPP-A düzeyleri ve gebelik yaşına göre küçük bebeklerin tahmin edilmesi. Journal of Clinical and Experimental Investigations, Cilt: 3 - Sayı: 2, 185–188. https://ajindex.com/articles/561899

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