Journals / Journal of Clinical and Analytical Medicine / 2011 / Cilt: 2 - Sayı: 1

The efect of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia

Helikobakteri pylori eradikasyonunun atrofik gastrit ve intestinal metaplazi üzerine olan etkisi

Pages
17–20
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results reported here are those obtained during the 6 months period.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia.
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Key Findings & Data:Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy.
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Conclusion & Impact:The results reported here are those obtained during the 6 months period.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea breath test 2 and 6 months after for helicobacter pylori eradication. Severity of gastric atrophy and intestinal metaplasia was classified as mild, moderate or severe according to the updated Sydney classification. Results The scoring of gastric atrophy was found significantly decreased in helicobacter pylori eradicated group after 6 months, while no significant change was found in H. pylori non-eradicated group. Intestinal metaplasia wasn’t recorded as improved in neither helicobacter pylori eradicated group nor helicobacter pylori noneradicated group. Conclusion It can be suggested that reversal of atrophy and intestinal metaplasia may occur even after several years, so the positive effect of eradication therapy might have been even better with a longer follow-up period. The results reported here are those obtained during the 6 months period.

Özet

Amaç Bu prospektif çalışmanın amacı helikobakter pilori eradikasyonunun intestinal metaplazi yada atrofik gastriti iyileştirip iyileştirmediğini değerlendirmektir. Gereç ve Yöntemler Helikobakter pilori enfeksiyonu olan 42 hasta merkezimizde atrofik gastrit ve intestinal metaplazi yönünden değerlendirildi. Helikobakter pilori eradikasyonundan önce ve altı ay sonra antrumdan ve korpusdan ikişer biyopsi alındı. Tedaviden 2 ve 6 ay sonra üre nefes testi ile helikobakter pilori durumuna bakıldı. Atrofik gastrit ve intestinal metaplazi derecesi güncelleştirilmiş Sydney klasifikasyonuna göre ciddi, orta ve hafif olarak sınıflandırıldı. Bulgular Altı ay sonra helikobakter pilori eradike edilen grupta gastrik atrofi skoru anlamlı olarak azalırken, helikobakter pilori eradike edilmeyen grupta ise anlamlı bir değişiklik olmadı. İntestinal metaplazi helikobakter pilori eradike edilen ve edilmeyen grupta değişmedi. Sonuç Atrofi ve intestinal metaplazinin kaybolmasının yıllar içinde olabileceği beklendiğinden eradikasyon tedavisinden sonraki pozitif etkiler uzun süreli takiplerde daha iyi görülebilir. Bunlar bizim 6. aydaki erken sonuçlarımızdır.

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Cite This Article

KİLCİLER, G., GÜLŞEN, M., UYGUN, A., POLAT, Z., KANTARCIOĞLU, M. (2022). The efect of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia. Journal of Clinical and Analytical Medicine, Cilt: 2 - Sayı: 1, 17–20. https://ajindex.com/articles/561463

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