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Journals / Journal of Clinical and Analytical Medicine / 2013 / Cilt: 4 - Sayı: 4

Kronik Obstrüktif Akciğer Hastalığında Nötrofilik İnflamasyon, Hava Yolu Obstrüksiyonu ve Serum İnterlökin-8 Düzeyleri İle Yüksek Rezolüsyonlu Bilgisayarlı Tomografi Bulguları Arasındaki Korelasyon

Correlation Between High-Resolution Computed Tomography, Neutrophilic Inflammation, Air-way Obstruction and Serum Interleukin-8 Levels in Chronic Obstructive Pulmonary Disease

Nilgün DEMİRCİ YILMAZ
Aydın YILMAZ
Yurdanur ERDOĞAN
Melike ATASEVER
İ. Atila KEYF
Hakan ERTÜRK
Pages
286–290
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A negative correlation between TLS and FEV1 and thenumber of neutrophils and FEV1 was observed among all subjects (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: In this study, the correlation between high-resolution computed tomography (HRCT) and neutrophilic inflammation, air-way obstruction and serumIL-8 levels was examined in subjects with stable COPD.
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Key Findings & Data:Material and Method:23 stage I, 15 Stage II and 12 Stage III IV patients with COPD were includedin the study. 10 healthy nonsmoking and 20 smoking participants were additionally included to comprise the control group.
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Conclusion & Impact:A negative correlation between TLS and FEV1 and thenumber of neutrophils and FEV1 was observed among all subjects (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: In this study, the correlation between high-resolution computed tomography (HRCT) and neutrophilic inflammation, air-way obstruction and serumIL-8 levels was examined in subjects with stable COPD. Material and Method:23 stage I, 15 Stage II and 12 Stage III IV patients with COPD were includedin the study. 10 healthy nonsmoking and 20 smoking participants were additionally included to comprise the control group. Pulmonary function tests,sputum induction and blood collection were performed and HRCT assessedusing the visual scoring method. Results: We observed that the forced expiratory volume per second (FEV1) decreased and the total lung score (TLS)increased in smoking groups. An elevated number of neutrophils was observed in parallel with increasing stages of COPD, whilst the number of macrophages decreased in parallel. As the stage of COPD increased, the levelsof IL-8 increased. A negative correlation between TLS and FEV1 and thenumber of neutrophils and FEV1 was observed among all subjects (p

Özet

Amaç: Bu çalışmada stabil KOAHlı olgularda nötrofilik inflamasyon, havayolu obstrüksiyonu ve serum interlökin-8(IL-8) düzeylerinin yüksek rezolüsyonlu bilgisayarlı tomografi ile ilişkisi araştırıldı. Gereç ve Yöntem: Şubat2005-Ocak 2006 tarihleri arasında 23 Evre I, 15 Evre II ve 12 Evre III-IV stabil KOAHlı hasta çalışmaya alındı. 10 sağlıklı sigara içmeyen, 20 sağlıklı sigara içen olgu çalışmaya kontrol grubu olarak dahil edildi. Solunum fonksiyon testleri yapıldı, balgam indüksiyonu ile eş zamanlı kan örneği alındı. Yüksek rezolüsyonlu bilgisayarlı tomografi çekildi ve görsel skorlama yöntemi iledeğerlendirildi. Bulgular: Sigara içen gruplarda KOAH evresi arttıkça FEV1değeri düşmekte toplam akciğer skoru (TAS) artmaktaydı. KOAH evresi artışı ile paralel olarak nötrofil sayısında artma, makrofaj sayısında ise azalmaizlendi. KOAH evresi arttıkça IL-8 düzeyi artmakta idi. TAS ile FEV1 arasındave nötrofil sayısı ile FEV1 arasında negatif korelasyon izlendi(p

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Cite This Article

YILMAZ, N. D., YILMAZ, A., ERDOĞAN, Y., ATASEVER, M., KEYF, İ. A., ERTÜRK, H. (2022). Kronik Obstrüktif Akciğer Hastalığında Nötrofilik İnflamasyon, Hava Yolu Obstrüksiyonu ve Serum İnterlökin-8 Düzeyleri İle Yüksek Rezolüsyonlu Bilgisayarlı Tomografi Bulguları Arasındaki Korelasyon. Journal of Clinical and Analytical Medicine, Cilt: 4 - Sayı: 4, 286–290. https://ajindex.com/articles/561326

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