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Journals / Journal of Clinical and Analytical Medicine / 2016 / Cilt: 7 - Sayı: 1

Serum Neopterin, Sistatin C ve Koroner Kalp Hastalığı Arasındaki İlişkinin Değerlendirilmesi

Evaluation of Relationship Between Serum Neopterin, Cystatin C and Coronary Heart Disease

Fusun USTUNER
Evren AKGOL
Huseyin Tugrul CELİK
Oguzhan TOKLU
Sedat ABUSOGLU
Murat YESİL
Banu ARSLAN
Hamit Yasar ELLİDAG
Pages
27–31
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The positive correlation between Gensini score and the biochemical markers offers us a potential use of these markers in evaluating the disease's severity.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It has been reported that neopterin, a key molecule for immun response organization, is released from active macrophages of atheromatous plaque and useful for cardiovascular risk stratification.
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Key Findings & Data:Material and Method: Coronary artery disease group and control group consisted of 75 subjects (61 males, 14 females, mean age 60.5±10) and 50 subjects (25 males, 25 females, mean age 56.9±10), respectively.
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Conclusion & Impact:The positive correlation between Gensini score and the biochemical markers offers us a potential use of these markers in evaluating the disease's severity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: It has been reported that neopterin, a key molecule for immun response organization, is released from active macrophages of atheromatous plaque and useful for cardiovascular risk stratification. The aim of this study was to investigate serum cystatin C and neopterin levels in patients with coronary artery disease and examine the relationship between these markers and cardiovascular risk factors. Material and Method: Coronary artery disease group and control group consisted of 75 subjects (61 males, 14 females, mean age 60.5±10) and 50 subjects (25 males, 25 females, mean age 56.9±10), respectively. Results: Serum neopterin concentrations were higher in coronary artery disease group compared to control group. A negative correlation was established between neopterin and high density lipoprotein cholesterol. Also, there was a positive correlation between Gensini score and cystatin C and neopterin. Discussion: Serum cystatin C and neopterin concentrations might be useful markers for determining the coronary artery disease's severity. According to this study, neopterin seems to be a stronger indicator of cardiovascular diseases compared to cystatin C. The positive correlation between Gensini score and the biochemical markers offers us a potential use of these markers in evaluating the disease's severity.

Özet

Amaç: İmmun yanıtın düzenlenmesinde anahtar bir molekül olan neopterinin aterom plaklarda aktif makrofajlardan salınmakta olup kardiyovasküler risk sınıflamasında faydalı olduğu bildirilmiştir. Bu çalışmanın amacı, koroner arter hastalarında serum sistatin C ve neopterin düzeylerini araştırmak ve bu belirteçler ile diğer kardiyovasküler risk faktörleri arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Koroner arter hasta ve kontrol grupları sırasıyla 75 (61 erkek, 14 kadın, ortalama yaş 60.5±10) ve 50 (25 erkek, 25 kadın, ortalama yaş 56.9±10) kişiden oluşmaktadır. Bulgular: Koroner arter hasta grubunda serum neopterin konsantrasyonları kontrol grubuna göre yüksekti. Neopterin ile yüksek dansiteli lipoprotein kolesterol arasında negative korelasyon vardı. Aynı zamanda Gensini skoru ile sistatin C ve neopterin arasında pozitif korelasyon mevcuttu. Tartışma: Koroner arter hastalığının şiddetini saptamada serum sistatin C ve neopterin konsantrasyonları kullanışlı belirteçler olabilir. Bu çalışmanın sonuçlarına gore neopterin, sistatin C'ye kıyasla kardiyovasküler hastalıkların daha güçlü bir göstergesi olarak görünmektedir. Gensini skoru ile biyokimyasal belirteçler arasında bulunan bu korelasyon bize hastalık aktivitesinin değerlendirilmesinde bu belirteçlerin kullanılabileceğini göstermektedir.

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Cite This Article

USTUNER, F., AKGOL, E., CELİK, H. T., TOKLU, O., ABUSOGLU, S., YESİL, M., ARSLAN, B., ELLİDAG, H. Y. (2022). Serum Neopterin, Sistatin C ve Koroner Kalp Hastalığı Arasındaki İlişkinin Değerlendirilmesi. Journal of Clinical and Analytical Medicine, Cilt: 7 - Sayı: 1, 27–31. https://ajindex.com/articles/560849

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References (10)

  1. Murray CJ,Lopez AD. Global mortality disability and the contribution of risk fac- tors: Global Burden of Disease study. Lancet 1997;349(9063):1436-42. Ross R. The pathogenesis of atherosclerosis. The New England Journal of Medi- cine 1986;314(8):488-500.
  2. W van Lammeren G, L Moll F, Borst GJ, de Kleijn DP, P M de Vries JP, Pasterkamp G. Atherosclerotic plaque biomarkers: beyond the horizon of the vulnerable plaque. Curr Cardiol Rev 2011;7(1):22-7.
  3. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice. A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circula- tion 2003;107(3):499-511
  4. Vera R, Anita S, Uldis K, Andrejs E, Matthias J, Karlis T et al. Association be- tween increased serum neopterin and homocysteine concentrations as well as pyridoxal-5-phosphate deficiency in patients with coronary heart disease. Pteri- dines 2001;12(3):130-4.
  5. Ray KK, Morrow DA, Sabatine MS, Shui A, Rifai N, Cannon CP et al. Long-term prognostic value of neopterin: a novel marker of monocyte activation in patients with acute coronary syndrome. Circulation 2007;115(24):3071-8. David J N. Cystatin C.Annals of Clinical Biochemistry 2002;39(2):89-104. Dharnidharka VR. Serum cystatin C in superior to serum creatinine as a marker of kidney function: a meta-analysis. Am J Kidney Dis 2002;40(2):221-6.
  6. Gu FF, Lu SZ, Chen YD, Zhou YJ, Song XT, Jin ZN et al. Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. Chin Med J (Engl) 2009;122(23):2820-6.
  7. Arinell K, Christensen K, Blanc S, Anders L, Ole F. Effect of prolonged standard- ized bed rest on cystatin C and other markers of cardiovascular risk. BMC Physiol 2011;9:11-17.
  8. Weiss G, Willeit J, Kiechl S, Fuchs D, Jarosch E, Oberhollenzer F et al. In- creased concentrations of neopterin in carotid atherosclerosis. Atherosclerosis 1994;106(2):263-71.
  9. Schumacher M, Halwachs G, Tatzber F, Fruhwald FM, Zweiker R, Watzinger N et al. Increased neopterin in patients with chronic and acute coronary syndromes. J Am Coll Cardiol 1997;30(3):703-7.
  10. Ozbek C, Baran I, Tütüncü A, Kuştarcı T, Karaağaç K, Ozbek A. Modest correla- tion between serum neopterin levels and Gensini scores in a cohort of patients undergoing coronary angiography. I